(45 nodes) Photoreceptor cell maintenance network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CRB1	Crumbs cell polarity complex component 1. (1017 aa)
	USH2A	Uncharacterized protein. (1213 aa)
	RHO	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
	CRB2	Crumbs cell polarity complex component 2. (1287 aa)
	CDHR1	Cadherin related family member 1. (859 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1432 aa)
	NPHP3	TPR_REGION domain-containing protein. (1356 aa)
	NPHP4	Uncharacterized protein. (514 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (493 aa)
	USH1G	USH1 protein network component sans. (461 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	G3TJG8_LOXAF	Uncharacterized protein. (1882 aa)
	CROCC	Ciliary rootlet coiled-coil, rootletin. (2023 aa)
	CLN8	TLC domain-containing protein. (288 aa)
	RP1	RP1 axonemal microtubule associated. (2104 aa)
	G3TPM6_LOXAF	Thioredoxin-like_fold domain-containing protein. (83 aa)
	BBS1	BBS1 domain-containing protein. (593 aa)
	BBS12	Bardet-Biedl syndrome 12. (713 aa)
	G3TXZ7_LOXAF	Uncharacterized protein. (131 aa)
	TULP1	Tubby-like protein; Belongs to the TUB family. (558 aa)
	USH1C	USH1 protein network component harmonin. (910 aa)
	IQCB1	IQ motif containing B1. (598 aa)
	CROCC2	Ciliary rootlet coiled-coil, rootletin family member 2. (1785 aa)
	G3U823_LOXAF	Uncharacterized protein. (208 aa)
	TUB	Tubby-like protein; Belongs to the TUB family. (506 aa)
	G3UB36_LOXAF	Uncharacterized protein. (101 aa)
	G3UCT1_LOXAF	Uncharacterized protein. (611 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (293 aa)
	G3UHJ9_LOXAF	Uncharacterized protein. (366 aa)
	ABCA4	ATP binding cassette subfamily A member 4. (2308 aa)
	G3UJY4_LOXAF	Uncharacterized protein. (299 aa)
	CDH23	Cadherin related 23. (3045 aa)
	MAK	Male germ cell associated kinase. (625 aa)
	SPATA7	Spermatogenesis associated 7. (576 aa)
	BBS10	Bardet-Biedl syndrome 10. (717 aa)
	USP45	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (819 aa)
	PCDH15	Protocadherin related 15. (1408 aa)
	DRAM2	DNA damage regulated autophagy modulator 2. (265 aa)
	BBS4	Bardet-Biedl syndrome 4. (506 aa)
	CNGB1	Cyclic nucleotide-binding domain-containing protein. (739 aa)
	ADGRV1	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6308 aa)
	BSG	Basigin (Ok blood group). (367 aa)
	MKKS	McKusick-Kaufman syndrome. (569 aa)
	PROM1	Prominin 1. (781 aa)
	NXNL1	Nucleoredoxin like 1. (189 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	CDHR1	ENSLAFP00000027417	ENSLAFP00000011755	ATP binding cassette subfamily A member 4.	Cadherin related family member 1.	0.402
ABCA4	NXNL1	ENSLAFP00000027417	ENSLAFP00000002095	ATP binding cassette subfamily A member 4.	Nucleoredoxin like 1.	0.532
ABCA4	PROM1	ENSLAFP00000027417	ENSLAFP00000003346	ATP binding cassette subfamily A member 4.	Prominin 1.	0.401
ABCA4	RHO	ENSLAFP00000027417	ENSLAFP00000001142	ATP binding cassette subfamily A member 4.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.457
ADGRV1	CDH23	ENSLAFP00000004002	ENSLAFP00000029454	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Cadherin related 23.	0.656
ADGRV1	CDHR1	ENSLAFP00000004002	ENSLAFP00000011755	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Cadherin related family member 1.	0.429
ADGRV1	PCDH15	ENSLAFP00000004002	ENSLAFP00000006876	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Protocadherin related 15.	0.578
ADGRV1	USH1C	ENSLAFP00000004002	ENSLAFP00000021787	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	USH1 protein network component harmonin.	0.785
ADGRV1	USH1G	ENSLAFP00000004002	ENSLAFP00000013513	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	USH1 protein network component sans.	0.658
ADGRV1	USH2A	ENSLAFP00000004002	ENSLAFP00000001458	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.487
BBS1	BBS10	ENSLAFP00000017420	ENSLAFP00000007872	BBS1 domain-containing protein.	Bardet-Biedl syndrome 10.	0.709
BBS1	BBS12	ENSLAFP00000017420	ENSLAFP00000018084	BBS1 domain-containing protein.	Bardet-Biedl syndrome 12.	0.629
BBS1	BBS2	ENSLAFP00000017420	ENSLAFP00000014529	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.992
BBS1	BBS4	ENSLAFP00000017420	ENSLAFP00000005841	BBS1 domain-containing protein.	Bardet-Biedl syndrome 4.	0.995
BBS1	MKKS	ENSLAFP00000017420	ENSLAFP00000003397	BBS1 domain-containing protein.	McKusick-Kaufman syndrome.	0.402
BBS1	NPHP3	ENSLAFP00000017420	ENSLAFP00000012327	BBS1 domain-containing protein.	TPR_REGION domain-containing protein.	0.497
BBS10	BBS1	ENSLAFP00000007872	ENSLAFP00000017420	Bardet-Biedl syndrome 10.	BBS1 domain-containing protein.	0.709
BBS10	BBS12	ENSLAFP00000007872	ENSLAFP00000018084	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 12.	0.861
BBS10	BBS2	ENSLAFP00000007872	ENSLAFP00000014529	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 2 protein homolog.	0.745
BBS10	BBS4	ENSLAFP00000007872	ENSLAFP00000005841	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 4.	0.637

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