STRINGSTRING
ZAP70 ZAP70 RHOH RHOH NLRP3 NLRP3 HLX HLX RASGRP1 RASGRP1 SART1 SART1 NFKBIZ NFKBIZ PTPRC PTPRC NFKBID NFKBID GATA3 GATA3 FOXP3 FOXP3 TGFBR2 TGFBR2 WNT10B WNT10B IFNG IFNG SASH3 SASH3 G3SWC6_LOXAF G3SWC6_LOXAF IL4I1 IL4I1 PIK3R6 PIK3R6 IL2RG IL2RG TGFB1 TGFB1 GLI3 GLI3 ANXA1 ANXA1 PCK1 PCK1 IL4 IL4 AP3B1 AP3B1 SHH SHH ADAM8 ADAM8 NCKAP1L NCKAP1L ITPKB ITPKB SYK SYK BCL6 BCL6 IL7R IL7R TESPA1 TESPA1 DUSP10 DUSP10 ZBTB16 ZBTB16 IL23A IL23A AMBRA1 AMBRA1 G3TEN6_LOXAF G3TEN6_LOXAF KAT5 KAT5 LEF1 LEF1 CD74 CD74 CD83 CD83 MYB MYB MALT1 MALT1 ZBTB1 ZBTB1 SHB SHB ZMIZ1 ZMIZ1 BAD BAD CD27 CD27 IHH IHH G3TZT1_LOXAF G3TZT1_LOXAF RIPK2 RIPK2 ADA ADA IL18 IL18 G3U5X1_LOXAF G3U5X1_LOXAF SOX13 SOX13 SOX11 SOX11 EGR3 EGR3 CCL19 CCL19 SOX4 SOX4 SOCS1 SOCS1 SOCS5 SOCS5 XBP1 XBP1 TNFSF9 TNFSF9 RAG1 RAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZAP70Tyrosine-protein kinase. (629 aa)
RHOHRas homolog family member H. (191 aa)
NLRP3NLR family pyrin domain containing 3. (1025 aa)
HLXH2.0 like homeobox. (491 aa)
RASGRP1RAS guanyl releasing protein 1. (792 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa)
NFKBIZNFKB inhibitor zeta. (719 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1291 aa)
NFKBIDNFKB inhibitor delta. (328 aa)
GATA3GATA binding protein 3. (443 aa)
FOXP3Forkhead box P3. (427 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SASH3SAM and SH3 domain containing 3. (375 aa)
G3SWC6_LOXAFUncharacterized protein. (93 aa)
IL4I1Amine oxidase. (501 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (507 aa)
IL2RGFibronectin type-III domain-containing protein. (368 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
GLI3GLI family zinc finger 3. (1586 aa)
ANXA1Annexin. (348 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
IL4Uncharacterized protein. (135 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1082 aa)
SHHSonic hedgehog signaling molecule. (337 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
NCKAP1LNCK associated protein 1 like. (1136 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (620 aa)
SYKTyrosine-protein kinase. (629 aa)
BCL6BCL6 transcription repressor. (708 aa)
IL7RInterleukin 7 receptor. (459 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (469 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
AMBRA1WD_REPEATS_REGION domain-containing protein. (766 aa)
G3TEN6_LOXAFIg-like domain-containing protein. (307 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (545 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CD74CD74 molecule. (280 aa)
CD83CD83 molecule. (206 aa)
MYBMYB proto-oncogene, transcription factor. (723 aa)
MALT1MALT1 paracaspase. (834 aa)
ZBTB1Zinc finger and BTB domain containing 1. (714 aa)
SHBSH2 domain-containing protein. (461 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (951 aa)
BADBCL2 associated agonist of cell death. (206 aa)
CD27CD27 molecule. (261 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
G3TZT1_LOXAFUncharacterized protein. (294 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
ADAAdenosine deaminase. (351 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (195 aa)
G3U5X1_LOXAFKinase; Belongs to the inositol phosphokinase (IPK) family. (305 aa)
SOX13SRY-box transcription factor 13. (700 aa)
SOX11Transcription factor SOX. (410 aa)
EGR3Early growth response 3. (349 aa)
CCL19C-C motif chemokine. (103 aa)
SOX4Transcription factor SOX. (354 aa)
SOCS1Suppressor of cytokine signaling 1. (154 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
XBP1X-box binding protein 1. (266 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (244 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.