STRINGSTRING
CBFA2T3 CBFA2T3 GIT1 GIT1 GCKR GCKR SLC4A1 SLC4A1 TP53 TP53 TGFB1 TGFB1 CLTC CLTC FAM3C FAM3C STAT3 STAT3 CLK2 CLK2 SOGA1 SOGA1 AP2A1 AP2A1 G3UDE4_LOXAF G3UDE4_LOXAF C1QTNF3 C1QTNF3 G3UHE5_LOXAF G3UHE5_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UI57_LOXAF G3UI57_LOXAF G3UJ00_LOXAF G3UJ00_LOXAF G3UK14_LOXAF G3UK14_LOXAF NCOR1 NCOR1 G3ULT4_LOXAF G3ULT4_LOXAF PLEK PLEK FOXA2 FOXA2 G3UAZ0_LOXAF G3UAZ0_LOXAF G3U6U6_LOXAF G3U6U6_LOXAF G3U6D1_LOXAF G3U6D1_LOXAF SIRT6 SIRT6 SERPINA12 SERPINA12 DDIT4 DDIT4 ACTN3 ACTN3 CRY1 CRY1 G3TXD8_LOXAF G3TXD8_LOXAF G3TS21_LOXAF G3TS21_LOXAF GCK GCK TIGAR TIGAR FLCN FLCN PPARA PPARA EP300 EP300 SIK1 SIK1 G3SS82_LOXAF G3SS82_LOXAF MST1 MST1 LEPR LEPR ADIPOQ ADIPOQ PASK PASK COX11 COX11 C1QTNF12 C1QTNF12 ERFE ERFE INPP5K INPP5K PGP PGP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (612 aa)
GIT1GIT ArfGAP 1. (770 aa)
GCKRGlucokinase regulator. (621 aa)
SLC4A1Anion exchange protein. (904 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1472 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (933 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
NCOR1Nuclear receptor corepressor 1. (2457 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
PLEKPleckstrin. (350 aa)
FOXA2Forkhead box A2. (446 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
SIRT6Sirtuin 6. (336 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
CRY1Cryptochrome circadian regulator 1. (606 aa)
G3TXD8_LOXAFUncharacterized protein. (147 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
GCKPhosphotransferase. (465 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
FLCNFolliculin. (578 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
EP300E1A binding protein p300. (2420 aa)
SIK1Uncharacterized protein. (795 aa)
G3SS82_LOXAFUncharacterized protein. (90 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
LEPRLeptin receptor. (835 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
PASKPAS domain containing serine/threonine kinase. (1331 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (275 aa)
C1QTNF12C1q and TNF related 12. (308 aa)
ERFEErythroferrone. (331 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (466 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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