STRINGSTRING
ERBB2 ERBB2 MUL1 MUL1 BCL2 BCL2 ITSN2 ITSN2 AKAP6 AKAP6 SUPV3L1 SUPV3L1 DLL1 DLL1 TSHR TSHR SOX15 SOX15 GOLGA4 GOLGA4 HLX HLX MAP2K5 MAP2K5 N6AMT1 N6AMT1 ADNP2 ADNP2 BMP10 BMP10 ZNF639 ZNF639 G3SPX5_LOXAF G3SPX5_LOXAF MMP14 MMP14 TGFB2 TGFB2 PLCB1 PLCB1 DDX49 DDX49 NRP1 NRP1 SLC6A3 SLC6A3 MAPT MAPT G3SS82_LOXAF G3SS82_LOXAF ADAM10 ADAM10 EFNA5 EFNA5 MKKS MKKS ADNP ADNP USP47 USP47 ANAPC2 ANAPC2 DBNL DBNL PTK2B PTK2B SASH3 SASH3 BMPR1A BMPR1A AGR2 AGR2 PROX1 PROX1 MTM1 MTM1 LGI1 LGI1 GPAM GPAM RNF157 RNF157 DRD2 DRD2 PEX5 PEX5 DERL2 DERL2 EXTL3 EXTL3 DERL3 DERL3 BBS4 BBS4 EXOSC2 EXOSC2 EDN1 EDN1 PIM1 PIM1 G3T030_LOXAF G3T030_LOXAF GATA6 GATA6 SLC44A4 SLC44A4 FGF2 FGF2 PLS1 PLS1 CYFIP1 CYFIP1 RFTN1 RFTN1 CDKN2AIP CDKN2AIP EZR EZR CDKL5 CDKL5 ADAM17 ADAM17 EXOSC9 EXOSC9 FXN FXN RIMS2 RIMS2 INO80 INO80 NOL12 NOL12 TBX5 TBX5 SRF SRF ZPR1 ZPR1 DNPH1 DNPH1 SYT4 SYT4 ZFPM2 ZFPM2 F2 F2 COMMD5 COMMD5 LEP LEP SDCBP SDCBP PLAA PLAA NEDD4L NEDD4L TRPV2 TRPV2 SLC9A1 SLC9A1 PSMD10 PSMD10 G3TA31_LOXAF G3TA31_LOXAF SEMA4D SEMA4D CREB1 CREB1 SMO SMO SYT1 SYT1 ZFYVE27 ZFYVE27 WNT3 WNT3 MEF2C MEF2C NIPBL NIPBL STAT5B STAT5B SLC23A2 SLC23A2 STAT5A STAT5A TRIM32 TRIM32 KLHL22 KLHL22 EGFR EGFR G3TE60_LOXAF G3TE60_LOXAF BMPR2 BMPR2 RND2 RND2 MTOR MTOR G3TG57_LOXAF G3TG57_LOXAF SEMA7A SEMA7A IST1 IST1 RAG2 RAG2 GHRHR GHRHR FAM122A FAM122A RUFY3 RUFY3 SYT17 SYT17 YBX3 YBX3 GHSR GHSR BBS2 BBS2 PPARD PPARD SYT2 SYT2 MYOD1 MYOD1 IL9 IL9 VILL VILL PPIB PPIB GH1 GH1 WNT2B WNT2B BRAT1 BRAT1 TBX20 TBX20 GLI1 GLI1 SYT3 SYT3 WNT2 WNT2 AGRN AGRN SPHK1 SPHK1 L1CAM L1CAM LPAR3 LPAR3 NOTCH1 NOTCH1 PARP2 PARP2 EXOSC4 EXOSC4 SHTN1 SHTN1 MFSD2A MFSD2A ISLR ISLR WNT3A WNT3A LIMK1 LIMK1 FGFR1OP FGFR1OP MTPN MTPN G3TWY9_LOXAF G3TWY9_LOXAF NGF NGF G3TXR0_LOXAF G3TXR0_LOXAF UCN UCN MAP1B MAP1B G3U095_LOXAF G3U095_LOXAF ARX ARX G3U0Z3_LOXAF G3U0Z3_LOXAF SFRP2 SFRP2 DISC1 DISC1 PPM1F PPM1F WT1 WT1 ACTN3 ACTN3 ZP3 ZP3 G3U5V7_LOXAF G3U5V7_LOXAF KDM2B KDM2B TGFBR1 TGFBR1 CIB1 CIB1 G3U777_LOXAF G3U777_LOXAF HOPX HOPX VIL1 VIL1 HPN HPN RIMS2-2 RIMS2-2 SFN SFN DBN1 DBN1 SMURF1 SMURF1 CSF1 CSF1 CHD7 CHD7 INSR INSR G3UFI6_LOXAF G3UFI6_LOXAF CXCL16 CXCL16 GHRH GHRH NCBP1 NCBP1 HDGFL2 HDGFL2 CELF1 CELF1 SMAD7 SMAD7 OCM2 OCM2 WFS1 WFS1 ARMC12 ARMC12 BDNF BDNF MEGF8 MEGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
ITSN2Intersectin 2. (1297 aa)
AKAP6A-kinase anchoring protein 6. (2304 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
SOX15SRY-box transcription factor 15. (225 aa)
GOLGA4Golgin A4. (2253 aa)
HLXH2.0 like homeobox. (491 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (446 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
ADNP2ADNP homeobox 2. (1135 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ZNF639Zinc finger protein 639. (485 aa)
G3SPX5_LOXAFC-type lectin domain-containing protein. (166 aa)
MMP14Matrix metallopeptidase 14. (583 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (479 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (921 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa)
MAPTMicrotubule-associated protein. (760 aa)
G3SS82_LOXAFUncharacterized protein. (90 aa)
ADAM10ADAM metallopeptidase domain 10. (639 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (187 aa)
MKKSMcKusick-Kaufman syndrome. (569 aa)
ADNPActivity dependent neuroprotector homeobox. (1101 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (834 aa)
DBNLDrebrin like. (428 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
SASH3SAM and SH3 domain containing 3. (375 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (172 aa)
PROX1Prospero homeobox 1. (737 aa)
MTM1Myotubularin 1. (603 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
RNF157Ring finger protein 157. (614 aa)
DRD2Dopamine receptor D2. (447 aa)
PEX5Peroxisomal biogenesis factor 5. (641 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (232 aa)
EXTL3Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (921 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (228 aa)
BBS4Bardet-Biedl syndrome 4. (506 aa)
EXOSC2Exosome component 2. (294 aa)
EDN1Endothelin 1. (202 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (317 aa)
G3T030_LOXAFUncharacterized protein. (796 aa)
GATA6Uncharacterized protein. (244 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (705 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
PLS1Plastin 1. (632 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1250 aa)
RFTN1Uncharacterized protein. (131 aa)
CDKN2AIPCDKN2A interacting protein. (532 aa)
EZREzrin. (587 aa)
CDKL5Cyclin dependent kinase like 5. (905 aa)
ADAM17ADAM metallopeptidase domain 17. (845 aa)
EXOSC9Exosome component 9. (441 aa)
FXNFrataxin. (208 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1077 aa)
INO80INO80 complex ATPase subunit. (1557 aa)
NOL12Uncharacterized protein. (212 aa)
TBX5T-box transcription factor 5. (519 aa)
SRFSerum response factor. (391 aa)
ZPR1ZPR1 zinc finger. (463 aa)
DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (163 aa)
SYT4Synaptotagmin 4. (428 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (619 aa)
COMMD5COMM domain containing 5. (224 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SDCBPSyndecan binding protein. (297 aa)
PLAAUncharacterized protein. (799 aa)
NEDD4LE3 ubiquitin-protein ligase. (940 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (757 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (825 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
G3TA31_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (343 aa)
SEMA4DSema domain-containing protein; Belongs to the semaphorin family. (302 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
SYT1Synaptotagmin 1. (422 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (413 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MEF2CMyocyte enhancer factor 2C. (473 aa)
NIPBLNipped-B protein. (2805 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
SLC23A2Solute carrier family 23 member 2. (649 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
TRIM32Tripartite motif containing 32. (654 aa)
KLHL22BTB domain-containing protein. (637 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
G3TE60_LOXAFRaptor_N domain-containing protein. (974 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
RND2Rho family GTPase 2. (227 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
G3TG57_LOXAFIlGF domain-containing protein. (118 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
IST1IST1 factor associated with ESCRT-III. (364 aa)
RAG2Recombination activating 2. (527 aa)
GHRHRGrowth hormone releasing hormone receptor. (375 aa)
FAM122AFamily with sequence similarity 122A. (285 aa)
RUFY3RUN and FYVE domain containing 3. (678 aa)
SYT17Synaptotagmin 17. (472 aa)
YBX3Y-box binding protein 3. (368 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SYT2Synaptotagmin 2. (419 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
IL9Interleukin 9. (143 aa)
VILLVillin like. (846 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
BRAT1BRCA1 associated ATM activator 1. (820 aa)
TBX20T-box transcription factor 20. (449 aa)
GLI1GLI family zinc finger 1. (1114 aa)
SYT3Synaptotagmin 3. (542 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
AGRNAgrin. (1957 aa)
SPHK1Sphingosine kinase 1. (386 aa)
L1CAML1 cell adhesion molecule. (1253 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
NOTCH1Uncharacterized protein. (698 aa)
PARP2Poly [ADP-ribose] polymerase. (569 aa)
EXOSC4Exosome component 4. (245 aa)
SHTN1Shootin 1. (633 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (531 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (433 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (197 aa)
LIMK1LIM domain kinase 1. (627 aa)
FGFR1OPFGFR1 oncogene partner. (403 aa)
MTPNMyotrophin. (118 aa)
G3TWY9_LOXAFANK_REP_REGION domain-containing protein. (225 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (242 aa)
G3TXR0_LOXAFUncharacterized protein. (785 aa)
UCNUrocortin. (117 aa)
MAP1BMicrotubule associated protein 1B. (2454 aa)
G3U095_LOXAFUncharacterized protein. (367 aa)
ARXAristaless related homeobox. (547 aa)
G3U0Z3_LOXAFUncharacterized protein. (353 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
DISC1Uncharacterized protein. (232 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (379 aa)
WT1WT1 transcription factor. (450 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
ZP3ZP domain-containing protein. (427 aa)
G3U5V7_LOXAFUncharacterized protein. (535 aa)
KDM2BLysine demethylase 2B. (1305 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (482 aa)
CIB1Calcium and integrin binding 1. (176 aa)
G3U777_LOXAFUncharacterized protein. (373 aa)
HOPXHomeobox domain-containing protein. (72 aa)
VIL1Villin 1. (827 aa)
HPNPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (400 aa)
RIMS2-2Uncharacterized protein. (171 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
DBN1Drebrin 1. (677 aa)
SMURF1E3 ubiquitin-protein ligase. (740 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
G3UFI6_LOXAFC-type lectin domain-containing protein. (131 aa)
CXCL16Uncharacterized protein. (233 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
HDGFL2HDGF like 2. (611 aa)
CELF1CUGBP Elav-like family member 1. (516 aa)
SMAD7Mothers against decapentaplegic homolog. (405 aa)
OCM2Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
WFS1Wolframin ER transmembrane glycoprotein. (787 aa)
ARMC12Armadillo repeat containing 12. (340 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
MEGF8Uncharacterized protein. (424 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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