STRINGSTRING
G3THQ5_LOXAF G3THQ5_LOXAF FNDC3B FNDC3B C1QL4 C1QL4 CD74 CD74 E2F1 E2F1 GAS6 GAS6 CDK6 CDK6 WNT2B WNT2B JUN JUN ZMIZ1 ZMIZ1 WNT2 WNT2 SPHK1 SPHK1 G3TPT5_LOXAF G3TPT5_LOXAF G3TS21_LOXAF G3TS21_LOXAF CDC73 CDC73 CAV1 CAV1 PLA2G1B PLA2G1B G3U1F6_LOXAF G3U1F6_LOXAF MORC3 MORC3 B4GALT7 B4GALT7 CD248 CD248 CDKN1A CDKN1A MED25 MED25 SIRT6 SIRT6 G3U6D1_LOXAF G3U6D1_LOXAF G3U6U6_LOXAF G3U6U6_LOXAF MED31 MED31 LIG4 LIG4 NF1 NF1 G3UAZ0_LOXAF G3UAZ0_LOXAF CTC1 CTC1 G3UDE4_LOXAF G3UDE4_LOXAF G3UEN1_LOXAF G3UEN1_LOXAF G3UHE5_LOXAF G3UHE5_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UI57_LOXAF G3UI57_LOXAF G3UJ00_LOXAF G3UJ00_LOXAF G3UK14_LOXAF G3UK14_LOXAF DHX9 DHX9 G3ULJ2_LOXAF G3ULJ2_LOXAF G3ULT4_LOXAF G3ULT4_LOXAF FBXO4 FBXO4 CDC6 CDC6 MYC MYC FBRS FBRS TP53INP1 TP53INP1 DDR2 DDR2 PML PML DACH1 DACH1 G3SRX5_LOXAF G3SRX5_LOXAF PEX2 PEX2 NGFR NGFR PARP10 PARP10 WNT1 WNT1 WAPL WAPL EMD EMD PAWR PAWR NLRC3 NLRC3 TP53 TP53 TGFB1 TGFB1 PDGFB PDGFB DAB2IP DAB2IP FOSL2 FOSL2 LZTS2 LZTS2 AQP1 AQP1 EREG EREG PDGFRA PDGFRA BRK1 BRK1 PDGFA PDGFA LIF LIF PDGFC PDGFC IFI30 IFI30 TRIM32 TRIM32 ITGB3 ITGB3 NDUFS4 NDUFS4 ESR1 ESR1 ZMPSTE24 ZMPSTE24 G3TG57_LOXAF G3TG57_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3THQ5_LOXAFRING-type domain-containing protein. (330 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
C1QL4Complement C1q like 4. (238 aa)
CD74CD74 molecule. (280 aa)
E2F1E2F transcription factor 1. (429 aa)
GAS6Growth arrest specific 6. (672 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (951 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SPHK1Sphingosine kinase 1. (386 aa)
G3TPT5_LOXAFUncharacterized protein. (201 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
CDC73Cell division cycle 73. (536 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (185 aa)
PLA2G1BPhospholipase A(2). (146 aa)
G3U1F6_LOXAFUncharacterized protein. (75 aa)
MORC3MORC family CW-type zinc finger 3. (948 aa)
B4GALT7Beta-1,4-galactosyltransferase 7. (327 aa)
CD248Uncharacterized protein. (278 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MED25Mediator complex subunit 25. (746 aa)
SIRT6Sirtuin 6. (336 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
LIG4DNA ligase. (913 aa)
NF1Neurofibromin 1. (2840 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
CTC1CST telomere replication complex component 1. (1220 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
G3UEN1_LOXAFUncharacterized protein. (201 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
DHX9DExH-box helicase 9. (1289 aa)
G3ULJ2_LOXAFUncharacterized protein. (202 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
FBXO4F-box protein 4. (387 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
FBRSUncharacterized protein. (362 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
PMLPromyelocytic leukemia. (861 aa)
DACH1Dachshund family transcription factor 1. (756 aa)
G3SRX5_LOXAFIg-like domain-containing protein. (305 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
NGFRNerve growth factor receptor. (414 aa)
PARP10Poly [ADP-ribose] polymerase. (967 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WAPLWAPL cohesin release factor. (1196 aa)
EMDEmerin. (242 aa)
PAWRUncharacterized protein. (51 aa)
NLRC3NLR family CARD domain containing 3. (1037 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (675 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
EREGEpiregulin. (163 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (191 aa)
LIFUncharacterized protein. (201 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
IFI30IFI30 lysosomal thiol reductase. (257 aa)
TRIM32Tripartite motif containing 32. (654 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
NDUFS4Uncharacterized protein. (83 aa)
ESR1NR LBD domain-containing protein. (232 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
G3TG57_LOXAFIlGF domain-containing protein. (118 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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