STRINGSTRING
CDKN1A CDKN1A IL18 IL18 PDCD4 PDCD4 APLN APLN S1PR2 S1PR2 STAT1 STAT1 G3TXD8_LOXAF G3TXD8_LOXAF AIF1 AIF1 IGFBP5 IGFBP5 G3TSL5_LOXAF G3TSL5_LOXAF EFEMP2 EFEMP2 TGFB3 TGFB3 PTGIR PTGIR CX3CL1 CX3CL1 CTNNBIP1 CTNNBIP1 IL10 IL10 JUN JUN MMP9 MMP9 CTNNB1 CTNNB1 IL6R IL6R NR4A3 NR4A3 PDGFRB PDGFRB G3TG57_LOXAF G3TG57_LOXAF IL12B IL12B ADAMTS1 ADAMTS1 IL6 IL6 MEF2D MEF2D BMPR2 BMPR2 FRS2 FRS2 ITGB3 ITGB3 IGFBP3 IGFBP3 MEF2C MEF2C BMP2 BMP2 PPARGC1A PPARGC1A GNA12 GNA12 TRIB1 TRIB1 BMP4 BMP4 NPR3 NPR3 MYOCD MYOCD APOD APOD PRKDC PRKDC XRCC6 XRCC6 XRCC5 XRCC5 GPER1 GPER1 EREG EREG PHB PHB SERPINF2 SERPINF2 PRKG1 PRKG1 HBEGF HBEGF ERN1 ERN1 FGF2 FGF2 PDGFB PDGFB SOD2 SOD2 EDN1 EDN1 SF1 SF1 NDRG2 NDRG2 VIP VIP BMPR1A BMPR1A HES5 HES5 ALOX12 ALOX12 IFNG IFNG CALCRL CALCRL ADIPOQ ADIPOQ MNAT1 MNAT1 VIPR2 VIPR2 PIK3CA PIK3CA FOXJ2 FOXJ2 DNMT1 DNMT1 DBH DBH THBS1 THBS1 DDR2 DDR2 MAP3K5 MAP3K5 IL12A IL12A LDLRAP1 LDLRAP1 CNN1 CNN1 NDRG4 NDRG4 CDH13 CDH13 MFN2 MFN2 GNA13 GNA13 FOXP1 FOXP1 TCF7L2 TCF7L2 TNFAIP3 TNFAIP3 IGF1R IGF1R P2RY6 P2RY6 NOTCH3 NOTCH3 HMOX1 HMOX1 CCDC142 CCDC142 NF1 NF1 G3U7L3_LOXAF G3U7L3_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (195 aa)
PDCD4Programmed cell death 4. (470 aa)
APLNApelin. (77 aa)
S1PR2Sphingosine-1-phosphate receptor 2. (352 aa)
STAT1Signal transducer and activator of transcription. (756 aa)
G3TXD8_LOXAFUncharacterized protein. (147 aa)
AIF1Allograft inflammatory factor 1. (140 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
G3TSL5_LOXAFUncharacterized protein. (222 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (327 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PTGIRProstaglandin I2 receptor. (423 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (393 aa)
CTNNBIP1Catenin beta interacting protein 1. (152 aa)
IL10Interleukin 10. (178 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
MMP9Matrix metallopeptidase 9. (729 aa)
CTNNB1Catenin beta 1. (780 aa)
IL6RInterleukin 6 receptor. (444 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (626 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
G3TG57_LOXAFIlGF domain-containing protein. (118 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
IL6Interleukin 6. (212 aa)
MEF2DMyocyte enhancer factor 2D. (517 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
IGFBP3Insulin like growth factor binding protein 3. (296 aa)
MEF2CMyocyte enhancer factor 2C. (473 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
GNA12G protein subunit alpha 12. (373 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NPR3Natriuretic peptide receptor 3. (537 aa)
MYOCDMyocardin. (937 aa)
APODApolipoprotein D. (190 aa)
PRKDCUncharacterized protein. (221 aa)
XRCC6Ku domain-containing protein. (611 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
EREGEpiregulin. (163 aa)
PHBProhibitin. (272 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (488 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (489 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (955 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (220 aa)
EDN1Endothelin 1. (202 aa)
SF1Splicing factor 1. (645 aa)
NDRG2NDRG family member 2. (371 aa)
VIPVasoactive intestinal peptide. (170 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
HES5Hes family bHLH transcription factor 5. (163 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (460 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (308 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (421 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXJ2Forkhead box J2. (571 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa)
DBHDopamine beta-hydroxylase. (620 aa)
THBS1Thrombospondin 1. (1169 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (219 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (281 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
NDRG4NDRG family member 4. (404 aa)
CDH13Cadherin 13. (457 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
GNA13G protein subunit alpha 13. (284 aa)
FOXP1Fork-head domain-containing protein. (683 aa)
TCF7L2Transcription factor 7 like 2. (445 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
NOTCH3Notch receptor 3. (2240 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CCDC142Coiled-coil domain containing 142. (746 aa)
NF1Neurofibromin 1. (2840 aa)
G3U7L3_LOXAFPI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (140 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.