STRINGSTRING
NF1 NF1 SHANK3 SHANK3 PSEN1 PSEN1 GSX2 GSX2 OTX1 OTX1 HESX1 HESX1 GDF7 GDF7 BBS1 BBS1 BBS2 BBS2 ZNF335 ZNF335 UCHL5 UCHL5 SMO SMO SLC6A4 SLC6A4 FANCD2 FANCD2 SOS1 SOS1 EMX1 EMX1 BBS4 BBS4 SLC4A10 SLC4A10 PAFAH1B1 PAFAH1B1 FBXW11 FBXW11 MKKS MKKS FANCC FANCC VPS51 VPS51
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin 1. (2840 aa)
SHANK3ANK_REP_REGION domain-containing protein. (342 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (440 aa)
GSX2Homeobox domain-containing protein. (93 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
HESX1HESX homeobox 1. (185 aa)
GDF7Growth differentiation factor 7. (449 aa)
BBS1BBS1 domain-containing protein. (593 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
ZNF335Zinc finger protein 335. (1345 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
FANCD2FA complementation group D2. (1453 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
EMX1Empty spiracles homeobox 1. (258 aa)
BBS4Bardet-Biedl syndrome 4. (506 aa)
SLC4A10Anion exchange protein. (1113 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
MKKSMcKusick-Kaufman syndrome. (569 aa)
FANCCFA complementation group C. (444 aa)
VPS51VPS51 subunit of GARP complex. (781 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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