STRINGSTRING
TTI2 TTI2 G3UI57_LOXAF G3UI57_LOXAF CCNH CCNH G3UHY3_LOXAF G3UHY3_LOXAF G3UHE5_LOXAF G3UHE5_LOXAF NCLN NCLN MAPK8IP3 MAPK8IP3 ATP1B2 ATP1B2 FBXW9 FBXW9 CSN3 CSN3 BAG5 BAG5 G3UDE4_LOXAF G3UDE4_LOXAF USP13 USP13 SOX17 SOX17 G3UCL2_LOXAF G3UCL2_LOXAF PEX19 PEX19 FLOT1 FLOT1 G3UAZ0_LOXAF G3UAZ0_LOXAF PRKRA PRKRA CDC37 CDC37 CRYAA CRYAA G3U8F6_LOXAF G3U8F6_LOXAF G3U6U6_LOXAF G3U6U6_LOXAF G3U6D1_LOXAF G3U6D1_LOXAF MT3 MT3 TSPAN16 TSPAN16 G3UNL7_LOXAF G3UNL7_LOXAF WFS1 WFS1 APOA2 APOA2 MORC3 MORC3 WDR81 WDR81 P3H1 P3H1 COG3 COG3 A1CF A1CF BAG3 BAG3 NAA16 NAA16 PLPP3 PLPP3 G3TS21_LOXAF G3TS21_LOXAF PDCL3 PDCL3 GRN GRN PHB2 PHB2 ZSWIM7 ZSWIM7 PPIB PPIB GTPBP4 GTPBP4 BAG4 BAG4 PIK3R1 PIK3R1 STX12 STX12 DSG1 DSG1 CD74 CD74 USP33 USP33 FBXW7 FBXW7 G3THW4_LOXAF G3THW4_LOXAF ATF7IP ATF7IP TRIM44 TRIM44 TBRG1 TBRG1 CALR CALR LAMP2 LAMP2 G3TG57_LOXAF G3TG57_LOXAF MTMR9 MTMR9 FLOT2 FLOT2 CLUL1 CLUL1 CHP1 CHP1 USP36 USP36 PEX6 PEX6 MSX1 MSX1 SAV1 SAV1 NLK NLK IFI30 IFI30 PINK1 PINK1 HPS4 HPS4 SMO SMO CREB1 CREB1 USP19 USP19 RAB21 RAB21 EFNA1 EFNA1 MUL1 MUL1 STXBP4 STXBP4 CDC37L1 CDC37L1 ZBED3 ZBED3 SYVN1 SYVN1 COG7 COG7 MDM4 MDM4 MCM8 MCM8 NAA15 NAA15 G3SR49_LOXAF G3SR49_LOXAF TELO2 TELO2 G3SS82_LOXAF G3SS82_LOXAF STK4 STK4 TSPAN1 TSPAN1 RABL3 RABL3 CHEK2 CHEK2 CCT7 CCT7 WNT10B WNT10B ZNF207 ZNF207 CCT4 CCT4 G3SUK2_LOXAF G3SUK2_LOXAF RASSF2 RASSF2 CAMLG CAMLG STK3 STK3 GLMP GLMP CCT3 CCT3 TMEM19 TMEM19 CREBL2 CREBL2 USP2 USP2 CCT5 CCT5 FLNA FLNA CCT2 CCT2 CRYAB CRYAB PDCD10 PDCD10 HIP1R HIP1R PIN1 PIN1 BAG2 BAG2 HYPK HYPK PIM1 PIM1 TP53 TP53 PIM2 PIM2 USP7 USP7 RPAP3 RPAP3 GET1 GET1 MFSD1 MFSD1 OTUD3 OTUD3 TSC1 TSC1 G3T2K6_LOXAF G3T2K6_LOXAF SUGT1 SUGT1 TMEM88 TMEM88 AHSP AHSP BAG6 BAG6 PHB PHB MARCHF7 MARCHF7 ATP1B3 ATP1B3 AAK1 AAK1 G3T9Z8_LOXAF G3T9Z8_LOXAF EP300 EP300 BAG1 BAG1 CTNND1 CTNND1 SWSAP1 SWSAP1 TAF9 TAF9 CDK7 CDK7 PARK7 PARK7 TAF9B TAF9B HIP1 HIP1 RTN4 RTN4 G3T7Q0_LOXAF G3T7Q0_LOXAF CLU CLU C10orf90 C10orf90 LAMP1 LAMP1 SAXO1 SAXO1 G3ULT4_LOXAF G3ULT4_LOXAF SMAD7 SMAD7 G3UKW5_LOXAF G3UKW5_LOXAF G3UKV2_LOXAF G3UKV2_LOXAF DNLZ DNLZ G3UK14_LOXAF G3UK14_LOXAF G3UJ00_LOXAF G3UJ00_LOXAF DVL1 DVL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTI2TELO2 interacting protein 2. (506 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
NCLNNicalin. (570 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1350 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (293 aa)
FBXW9F-box and WD repeat domain containing 9. (299 aa)
CSN3Casein kappa. (181 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (866 aa)
SOX17SRY-box transcription factor 17. (391 aa)
G3UCL2_LOXAFUPAR/Ly6 domain-containing protein. (190 aa)
PEX19Uncharacterized protein. (300 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (244 aa)
CDC37Cell division cycle 37. (381 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA; Belongs to the small heat shock protein (HSP20) family. (196 aa)
G3U8F6_LOXAFGp_dh_C domain-containing protein. (71 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
TSPAN16Tetraspanin 16; Belongs to the tetraspanin (TM4SF) family. (239 aa)
G3UNL7_LOXAFGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
WFS1Wolframin ER transmembrane glycoprotein. (787 aa)
APOA2Apolipoprotein A2. (105 aa)
MORC3MORC family CW-type zinc finger 3. (948 aa)
WDR81WD repeat domain 81. (1939 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
COG3Component of oligomeric golgi complex 3. (831 aa)
A1CFAPOBEC1 complementation factor. (595 aa)
BAG3BCL2 associated athanogene 3. (517 aa)
NAA16N(alpha)-acetyltransferase 16, NatA auxiliary subunit. (865 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
PDCL3Phosducin like 3. (238 aa)
GRNGranulin precursor. (607 aa)
PHB2Prohibitin. (300 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (109 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1055 aa)
CD74CD74 molecule. (280 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (914 aa)
FBXW7F-box and WD repeat domain containing 7. (710 aa)
G3THW4_LOXAFCalreticulin. (420 aa)
ATF7IPActivating transcription factor 7 interacting protein. (1259 aa)
TRIM44Tripartite motif containing 44. (250 aa)
TBRG1Transforming growth factor beta regulator 1. (410 aa)
CALRCalreticulin. (414 aa)
LAMP2Lysosomal associated membrane protein 2. (413 aa)
G3TG57_LOXAFIlGF domain-containing protein. (118 aa)
MTMR9Myotubularin related protein 9. (545 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (481 aa)
CLUL1CLb domain-containing protein. (328 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1122 aa)
PEX6Peroxisomal biogenesis factor 6. (978 aa)
MSX1Msh homeobox 1. (297 aa)
SAV1Salvador family WW domain containing protein 1. (327 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
IFI30IFI30 lysosomal thiol reductase. (257 aa)
PINK1PTEN induced kinase 1. (582 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (677 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
USP19Ubiquitin specific peptidase 19. (1361 aa)
RAB21RAB21, member RAS oncogene family. (222 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
STXBP4Syntaxin binding protein 4. (361 aa)
CDC37L1Cell division cycle 37 like 1. (249 aa)
ZBED3Zinc finger BED-type containing 3. (202 aa)
SYVN1Synoviolin 1. (627 aa)
COG7Component of oligomeric golgi complex 7. (770 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit. (865 aa)
G3SR49_LOXAFGlyceraldehyde-3-phosphate dehydrogenase. (325 aa)
TELO2Telomere maintenance 2. (834 aa)
G3SS82_LOXAFUncharacterized protein. (90 aa)
STK4Serine/threonine kinase 4. (511 aa)
TSPAN1Tetraspanin. (238 aa)
RABL3RAB, member of RAS oncogene family like 3. (236 aa)
CHEK2Checkpoint kinase 2. (550 aa)
CCT7T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (544 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ZNF207Zinc finger protein 207. (497 aa)
CCT4T-complex protein 1 subunit delta. (539 aa)
G3SUK2_LOXAFUncharacterized protein. (1692 aa)
RASSF2Ras association domain family member 2. (326 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
STK3Serine/threonine kinase 3. (497 aa)
GLMPGlycosylated lysosomal membrane protein. (406 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
TMEM19Transmembrane protein 19. (350 aa)
CREBL2cAMP responsive element binding protein like 2. (170 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (576 aa)
CCT5Chaperonin containing TCP1 subunit 5. (541 aa)
FLNAFilamin A. (2521 aa)
CCT2Uncharacterized protein. (534 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (176 aa)
PDCD10Programmed cell death 10. (212 aa)
HIP1RHuntingtin interacting protein 1 related. (1065 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
BAG2BCL2 associated athanogene 2. (212 aa)
HYPKHuntingtin interacting protein K. (128 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (317 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (367 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1078 aa)
RPAP3RNA polymerase II associated protein 3. (666 aa)
GET1Guided entry of tail-anchored proteins factor 1. (174 aa)
MFSD1Major facilitator superfamily domain containing 1. (415 aa)
OTUD3OTU deubiquitinase 3. (396 aa)
TSC1TSC complex subunit 1. (869 aa)
G3T2K6_LOXAFMyotubularin phosphatase domain-containing protein. (520 aa)
SUGT1SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (339 aa)
TMEM88Transmembrane protein 88. (153 aa)
AHSPAlpha hemoglobin stabilizing protein. (102 aa)
BAG6BCL2 associated athanogene 6. (1151 aa)
PHBProhibitin. (272 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (688 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
AAK1AP2 associated kinase 1. (967 aa)
G3T9Z8_LOXAFUncharacterized protein. (355 aa)
EP300E1A binding protein p300. (2420 aa)
BAG1BCL2 associated athanogene 1. (321 aa)
CTNND1Catenin delta 1. (964 aa)
SWSAP1SWIM-type zinc finger 7 associated protein 1. (229 aa)
TAF9TATA-box binding protein associated factor 9. (266 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
TAF9BTATA-box binding protein associated factor 9b. (256 aa)
HIP1Huntingtin interacting protein 1. (1013 aa)
RTN4Reticulon. (1011 aa)
G3T7Q0_LOXAFUncharacterized protein. (565 aa)
CLUClusterin; Belongs to the clusterin family. (418 aa)
C10orf90Chromosome 10 open reading frame 90. (613 aa)
LAMP1Lysosomal associated membrane protein 1. (414 aa)
SAXO1Stabilizer of axonemal microtubules 1. (465 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
SMAD7Mothers against decapentaplegic homolog. (405 aa)
G3UKW5_LOXAFUncharacterized protein. (163 aa)
G3UKV2_LOXAFCCHC NOA-type domain-containing protein. (353 aa)
DNLZDNL-type zinc finger. (133 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
DVL1Dishevelled segment polarity protein 1. (621 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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