(49 nodes) Regulation of release of sequestered calcium ion into cytosol network (Loxodonta africana)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	AKAP6	A-kinase anchoring protein 6. (2304 aa)
	JPH2	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (685 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (403 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (973 aa)
	TRPC1	Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (744 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
	CYBA	Cytochrome b-245 alpha chain. (169 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1363 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (393 aa)
	RYR2	Ryanodine receptor 2. (4951 aa)
	G3SZS8_LOXAF	Uncharacterized protein. (135 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (619 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (638 aa)
	JSRP1	Junctional sarcoplasmic reticulum protein 1. (292 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (245 aa)
	HTT	Huntingtin. (3126 aa)
	JPH3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (738 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (778 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
	NPSR1	Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (393 aa)
	SELENON	Selenoprotein N. (498 aa)
	G3TTP7_LOXAF	Uncharacterized protein. (60 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (459 aa)
	FKBP1A	Peptidylprolyl isomerase. (137 aa)
	F2RL3	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	G3U4G1_LOXAF	Ig-like domain-containing protein. (504 aa)
	SRI	Sorcin. (199 aa)
	TMEM38A	Transmembrane protein 38A. (257 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	CXCL9	C-X-C motif chemokine. (126 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	HRC	Histidine rich calcium binding protein. (642 aa)
	JPH1	Junctophilin 1. (561 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2997 aa)
	TMEM38B	Transmembrane protein 38B. (231 aa)
	CXCL11	C-X-C motif chemokine. (100 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	RYR2	ENSLAFP00000000607	ENSLAFP00000005517	A-kinase anchoring protein 6.	Ryanodine receptor 2.	0.760
ATG5	HTT	ENSLAFP00000014297	ENSLAFP00000010901	Autophagy protein 5; Involved in autophagic vesicle formation.	Huntingtin.	0.503
CASQ1	CASQ2	ENSLAFP00000005424	ENSLAFP00000002721	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.902
CASQ1	G3SZS8_LOXAF	ENSLAFP00000005424	ENSLAFP00000006155	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Uncharacterized protein.	0.478
CASQ1	G3TTP7_LOXAF	ENSLAFP00000005424	ENSLAFP00000018955	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Uncharacterized protein.	0.478
CASQ1	JPH2	ENSLAFP00000005424	ENSLAFP00000001440	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.	0.463
CASQ1	RYR2	ENSLAFP00000005424	ENSLAFP00000005517	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.942
CASQ2	CASQ1	ENSLAFP00000002721	ENSLAFP00000005424	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.902
CASQ2	G3SZS8_LOXAF	ENSLAFP00000002721	ENSLAFP00000006155	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Uncharacterized protein.	0.478
CASQ2	G3TTP7_LOXAF	ENSLAFP00000002721	ENSLAFP00000018955	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Uncharacterized protein.	0.478
CASQ2	JPH2	ENSLAFP00000002721	ENSLAFP00000001440	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.	0.463
CASQ2	RYR2	ENSLAFP00000002721	ENSLAFP00000005517	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.942
CORO1A	PTPN6	ENSLAFP00000021235	ENSLAFP00000019274	Coronin; Belongs to the WD repeat coronin family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.442
CX3CL1	CXCL10	ENSLAFP00000016725	ENSLAFP00000006646	C-X3-C motif chemokine ligand 1.	C-X-C motif chemokine.	0.687
CX3CL1	CXCL9	ENSLAFP00000016725	ENSLAFP00000025166	C-X3-C motif chemokine ligand 1.	C-X-C motif chemokine.	0.645
CX3CL1	CXCR3	ENSLAFP00000016725	ENSLAFP00000029194	C-X3-C motif chemokine ligand 1.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.887
CXCL10	CX3CL1	ENSLAFP00000006646	ENSLAFP00000016725	C-X-C motif chemokine.	C-X3-C motif chemokine ligand 1.	0.687
CXCL10	CXCL11	ENSLAFP00000006646	ENSLAFP00000028671	C-X-C motif chemokine.	C-X-C motif chemokine.	0.970
CXCL10	CXCL9	ENSLAFP00000006646	ENSLAFP00000025166	C-X-C motif chemokine.	C-X-C motif chemokine.	0.998
CXCL10	CXCR3	ENSLAFP00000006646	ENSLAFP00000029194	C-X-C motif chemokine.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.983

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