STRINGSTRING
BRAF BRAF HOXB3 HOXB3 CRISPLD2 CRISPLD2 PTPN11 PTPN11 MKKS MKKS CRISPLD1 CRISPLD1 BBS4 BBS4 TGFB1 TGFB1 SGPL1 SGPL1 TIPARP TIPARP ZFAND5 ZFAND5 MAPK3 MAPK3 RRAS RRAS EDNRA EDNRA COL1A1 COL1A1 CHD7 CHD7 ANKRD11 ANKRD11 DKK1 DKK1 NOG NOG MAPK1 MAPK1 SRF SRF ALDH1A3 ALDH1A3 PDGFRA PDGFRA STRA6 STRA6 RAB3GAP1 RAB3GAP1 EP300 EP300 NIPBL NIPBL MSX1 MSX1 ARID5B ARID5B LEF1 LEF1 PAX9 PAX9 CSRNP1 CSRNP1 ALDH1A2 ALDH1A2 DLX5 DLX5 TBX1 TBX1 TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRAFB-Raf proto-oncogene, serine/threonine kinase. (740 aa)
HOXB3Homeobox B3. (430 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2; Belongs to the CRISP family. (498 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MKKSMcKusick-Kaufman syndrome. (569 aa)
CRISPLD1Cysteine rich secretory protein LCCL domain containing 1. (501 aa)
BBS4Bardet-Biedl syndrome 4. (506 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (658 aa)
ZFAND5Zinc finger AN1-type containing 5. (258 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
RRASRAS related. (219 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (425 aa)
COL1A1Collagen type I alpha 1 chain. (1455 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
ANKRD11Ankyrin repeat domain 11. (2630 aa)
DKK1Dickkopf-like protein 1. (268 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (219 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
SRFSerum response factor. (391 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (479 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
STRA6Stimulated by retinoic acid 6. (669 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (977 aa)
EP300E1A binding protein p300. (2420 aa)
NIPBLNipped-B protein. (2805 aa)
MSX1Msh homeobox 1. (297 aa)
ARID5BAT-rich interaction domain 5B. (1188 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
PAX9Paired box 9. (362 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (571 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (479 aa)
DLX5Distal-less homeobox 5. (289 aa)
TBX1T-box transcription factor 1. (503 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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