STRINGSTRING
CSF1 CSF1 G3UN68_LOXAF G3UN68_LOXAF SOSTDC1 SOSTDC1 CSMD2 CSMD2 G3UJ64_LOXAF G3UJ64_LOXAF KDM5B KDM5B LRP5 LRP5 PML PML AR AR WNT4 WNT4 PHB2 PHB2 G3TLU3_LOXAF G3TLU3_LOXAF BTRC BTRC ESR1 ESR1 DDR1 DDR1 LRRC1 LRRC1 AREG AREG EPHA2 EPHA2 TGFB1 TGFB1 PTCH1 PTCH1 VDR VDR MST1 MST1 MED1 MED1 CSMD1 CSMD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
G3UN68_LOXAFUncharacterized protein. (757 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
CSMD2CUB and Sushi multiple domains 2. (3053 aa)
G3UJ64_LOXAFUncharacterized protein. (1460 aa)
KDM5BLysine demethylase 5B. (1476 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1605 aa)
PMLPromyelocytic leukemia. (861 aa)
ARAndrogen receptor. (897 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PHB2Prohibitin. (300 aa)
G3TLU3_LOXAFUncharacterized protein. (134 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (593 aa)
ESR1NR LBD domain-containing protein. (232 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (914 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
AREGAmphiregulin. (249 aa)
EPHA2EPH receptor A2. (977 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PTCH1Patched 1. (1438 aa)
VDRVitamin D receptor. (424 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
CSMD1Uncharacterized protein. (2344 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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