STRINGSTRING
PID1 PID1 SIK1 SIK1 TSPO TSPO SLC27A4 SLC27A4 SIRT4 SIRT4 INSIG2 INSIG2 MST1 MST1 LEPR LEPR ADIPOQ ADIPOQ PGP PGP DKK3 DKK3 GIT1 GIT1 FMO4 FMO4 WDTC1 WDTC1 PROX1 PROX1 TRIB3 TRIB3 SLC4A1 SLC4A1 TP53 TP53 PARP1 PARP1 ACMSD ACMSD LOC100660588 LOC100660588 PIBF1 PIBF1 SIRT1 SIRT1 SNAI2 SNAI2 NFKB1 NFKB1 FAM3C FAM3C CYP27B1 CYP27B1 ERFE ERFE C1QTNF12 C1QTNF12 ERLIN2 ERLIN2 EP300 EP300 ATCAY ATCAY ATP2B4 ATP2B4 PPARA PPARA CDA CDA APPL2 APPL2 APOE APOE BRCA1 BRCA1 FLCN FLCN DKKL1 DKKL1 FMO2 FMO2 TIGAR TIGAR RD3 RD3 ACADVL ACADVL CBFA2T3 CBFA2T3 PRMT3 PRMT3 ERLIN1 ERLIN1 GCK GCK PLIN5 PLIN5 FMO1 FMO1 G3TS21_LOXAF G3TS21_LOXAF MFSD2A MFSD2A WNT4 WNT4 G3TWY0_LOXAF G3TWY0_LOXAF ETFBKMT ETFBKMT CRY1 CRY1 PDZD3 PDZD3 ACTN3 ACTN3 DDIT4 DDIT4 SERPINA12 SERPINA12 SIRT6 SIRT6 G3U6D1_LOXAF G3U6D1_LOXAF G3U6U6_LOXAF G3U6U6_LOXAF REST REST MALRD1 MALRD1 G3UAZ0_LOXAF G3UAZ0_LOXAF INSIG1 INSIG1 SOGA1 SOGA1 CLK2 CLK2 STAT3 STAT3 G3UDE4_LOXAF G3UDE4_LOXAF C1QTNF3 C1QTNF3 G3UHE5_LOXAF G3UHE5_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UI57_LOXAF G3UI57_LOXAF G3UJ00_LOXAF G3UJ00_LOXAF G3UK14_LOXAF G3UK14_LOXAF NCOR1 NCOR1 SNAI1 SNAI1 G3ULT4_LOXAF G3ULT4_LOXAF PLEK PLEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PID1Phosphotyrosine interaction domain containing 1. (203 aa)
SIK1Uncharacterized protein. (795 aa)
TSPOTranslocator protein. (169 aa)
SLC27A4Solute carrier family 27 member 4. (644 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
LEPRLeptin receptor. (835 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (282 aa)
GIT1GIT ArfGAP 1. (770 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (555 aa)
WDTC1WD and tetratricopeptide repeats 1. (677 aa)
PROX1Prospero homeobox 1. (737 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
SLC4A1Anion exchange protein. (904 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (974 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
LOC100660588Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (730 aa)
SIRT1Sirtuin 1. (605 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ERFEErythroferrone. (331 aa)
C1QTNF12C1q and TNF related 12. (308 aa)
ERLIN2ER lipid raft associated 2. (339 aa)
EP300E1A binding protein p300. (2420 aa)
ATCAYATCAY kinesin light chain interacting caytaxin. (350 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1208 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
APOEApolipoprotein E. (314 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1854 aa)
FLCNFolliculin. (578 aa)
DKKL1Dickkopf like acrosomal protein 1. (233 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (197 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (612 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (449 aa)
ERLIN1ER lipid raft associated 1. (350 aa)
GCKPhosphotransferase. (465 aa)
PLIN5Perilipin; Belongs to the perilipin family. (371 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (531 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
G3TWY0_LOXAFUncharacterized protein. (88 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
CRY1Cryptochrome circadian regulator 1. (606 aa)
PDZD3PDZ domain containing 3. (503 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
SIRT6Sirtuin 6. (336 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
RESTRE1 silencing transcription factor. (1067 aa)
MALRD1Uncharacterized protein. (351 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (263 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1472 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
NCOR1Nuclear receptor corepressor 1. (2457 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
PLEKPleckstrin. (350 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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