STRINGSTRING
TDP2 TDP2 CHFR CHFR TP53INP1 TP53INP1 MLIP MLIP G3SPK1_LOXAF G3SPK1_LOXAF ZMYM2 ZMYM2 PML PML CHEK2 CHEK2 CIITA CIITA RNF111 RNF111 PTEN PTEN TP53 TP53 BLM BLM G3UN99_LOXAF G3UN99_LOXAF G3ULT4_LOXAF G3ULT4_LOXAF G3UK14_LOXAF G3UK14_LOXAF G3UJ15_LOXAF G3UJ15_LOXAF G3UJ00_LOXAF G3UJ00_LOXAF G3UI57_LOXAF G3UI57_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UHE5_LOXAF G3UHE5_LOXAF G3UE49_LOXAF G3UE49_LOXAF SUMO2 SUMO2 G3UDE4_LOXAF G3UDE4_LOXAF G3UAZ0_LOXAF G3UAZ0_LOXAF G3UAE1_LOXAF G3UAE1_LOXAF G3U994_LOXAF G3U994_LOXAF G3U6U6_LOXAF G3U6U6_LOXAF G3U6D1_LOXAF G3U6D1_LOXAF RNF6 RNF6 G3U4L1_LOXAF G3U4L1_LOXAF HIPK2 HIPK2 MORC3 MORC3 RNF4 RNF4 RDM1 RDM1 DAXX DAXX LRCH4 LRCH4 RPAIN RPAIN MAPK7 MAPK7 ANKRD2 ANKRD2 CASP8AP2 CASP8AP2 ZBTB16 ZBTB16 RPA1 RPA1 KLHL20 KLHL20 CALCOCO2 CALCOCO2 TRIM16 TRIM16 N4BP1 N4BP1 HSF1 HSF1 IKBKE IKBKE SUMO1 SUMO1 TP53INP2 TP53INP2 TRIM8 TRIM8 G3TRR6_LOXAF G3TRR6_LOXAF G3TS21_LOXAF G3TS21_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TDP2Tyrosyl-DNA phosphodiesterase 2. (352 aa)
CHFRCheckpoint with forkhead and ring finger domains. (660 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
MLIPMuscular LMNA interacting protein. (795 aa)
G3SPK1_LOXAFSmall ubiquitin-related modifier. (87 aa)
ZMYM2Zinc finger MYM-type containing 2. (1377 aa)
PMLPromyelocytic leukemia. (861 aa)
CHEK2Checkpoint kinase 2. (550 aa)
CIITAClass II major histocompatibility complex transactivator. (1150 aa)
RNF111Ring finger protein 111. (992 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
BLMUncharacterized protein. (528 aa)
G3UN99_LOXAFSmall ubiquitin-related modifier. (100 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
G3UJ15_LOXAFETS domain-containing protein. (442 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UE49_LOXAFSmall ubiquitin-related modifier. (95 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
G3UAE1_LOXAFUncharacterized protein. (224 aa)
G3U994_LOXAFSmall ubiquitin-related modifier. (95 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
RNF6Ring finger protein 6. (683 aa)
G3U4L1_LOXAFRING-type domain-containing protein. (192 aa)
HIPK2Homeodomain interacting protein kinase 2. (1207 aa)
MORC3MORC family CW-type zinc finger 3. (948 aa)
RNF4Ring finger protein 4. (194 aa)
RDM1RAD52 motif containing 1. (284 aa)
DAXXDeath domain associated protein. (689 aa)
LRCH4Leucine rich repeats and calponin homology domain containing 4. (678 aa)
RPAINRPA interacting protein. (219 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (801 aa)
ANKRD2Ankyrin repeat domain 2. (332 aa)
CASP8AP2Caspase 8 associated protein 2. (1974 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (643 aa)
KLHL20Kelch like family member 20. (627 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (450 aa)
TRIM16Uncharacterized protein. (549 aa)
N4BP1NEDD4 binding protein 1. (825 aa)
HSF1Heat shock transcription factor 1. (503 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (722 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
TRIM8Tripartite motif containing 8. (461 aa)
G3TRR6_LOXAFUncharacterized protein. (486 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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