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FAH FAH P4HA1 P4HA1 PDK2 PDK2 ETFA ETFA G3UMT9_LOXAF G3UMT9_LOXAF NDUFS6 NDUFS6 LOC100666038 LOC100666038 CAT CAT NDUFS8 NDUFS8 DBT DBT NDUFA6 NDUFA6 XK XK LOC100676911 LOC100676911 MRPS36 MRPS36 NCF2 NCF2 SDHC SDHC RRM1 RRM1 PDHA2 PDHA2 OGDHL OGDHL NCF4 NCF4 NDUFB2 NDUFB2 YJEFN3 YJEFN3 GPD2 GPD2 UQCRC1 UQCRC1 GLDC GLDC GPD1 GPD1 NDUFAB1 NDUFAB1 P4HB P4HB NDUFV3 NDUFV3 SIRT4 SIRT4 UQCRB UQCRB SDHD SDHD NDUFB11 NDUFB11 PDHB PDHB XKRX XKRX G3SUS8_LOXAF G3SUS8_LOXAF PDK1 PDK1 CYBA CYBA NDUFB6 NDUFB6 DLAT DLAT AMT AMT FOXRED1 FOXRED1 GPX2 GPX2 NDUFC1 NDUFC1 UQCRQ UQCRQ PYCR3 PYCR3 UQCR10 UQCR10 BCKDHB BCKDHB CLPB CLPB XDH XDH GLOD5 GLOD5 GLUD1 GLUD1 GPX8 GPX8 DLST DLST CYBB CYBB PDHX PDHX NOX3 NOX3 OGDH OGDH NDUFS1 NDUFS1 GMPR2 GMPR2 GPD1L GPD1L ETFDH ETFDH RRM2B RRM2B CYB5R3 CYB5R3 NDUFS4 NDUFS4 GMPR GMPR UQCRC2 UQCRC2 GCSH GCSH GPX6 GPX6 G3TFW7_LOXAF G3TFW7_LOXAF HAO1 HAO1 CBR4 CBR4 NDUFB8 NDUFB8 NOX4 NOX4 DUOX2 DUOX2 DUOX1 DUOX1 NCF1 NCF1 NDUFS3 NDUFS3 NDUFA3 NDUFA3 SDHA SDHA NDUFA7 NDUFA7 SDHB SDHB GPX3 GPX3 BCKDK BCKDK ETFB ETFB NDUFA13 NDUFA13 NDUFB4 NDUFB4 DHDH DHDH DMAC2 DMAC2 NDUFA9 NDUFA9 ARHGEF4 ARHGEF4 NDUFB5 NDUFB5 AGT AGT NDUFA5 NDUFA5 NDUFS7 NDUFS7 PSTK PSTK BCKDHA BCKDHA RRM2 RRM2 CYB5B CYB5B ALKBH6 ALKBH6 G3UFM1_LOXAF G3UFM1_LOXAF G3UH69_LOXAF G3UH69_LOXAF PDHA1 PDHA1 LOC104846773 LOC104846773
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAHFumarylacetoacetase. (395 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (536 aa)
PDK2Protein-serine/threonine kinase. (362 aa)
ETFAElectron transfer flavoprotein subunit alpha. (334 aa)
G3UMT9_LOXAFUncharacterized protein. (76 aa)
NDUFS6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (124 aa)
LOC100666038Uncharacterized protein. (55 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
NDUFS8NADH:ubiquinone oxidoreductase core subunit S8. (210 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
NDUFA6Uncharacterized protein; Belongs to the complex I LYR family. (82 aa)
XKXK-related protein. (397 aa)
LOC100676911Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
MRPS36Mitochondrial ribosomal protein S36. (102 aa)
NCF2Neutrophil cytosolic factor 2. (520 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (392 aa)
OGDHLOxoglutarate dehydrogenase like. (1011 aa)
NCF4Neutrophil cytosolic factor 4. (333 aa)
NDUFB2NADH:ubiquinone oxidoreductase subunit B2. (74 aa)
YJEFN3YjeF N-terminal domain-containing protein. (230 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (745 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (985 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
P4HBProtein disulfide-isomerase. (509 aa)
NDUFV3NADH:ubiquinone oxidoreductase subunit V3. (460 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
UQCRBCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (106 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (156 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (122 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
XKRXXK-related protein. (449 aa)
G3SUS8_LOXAFSH3 domain-containing protein. (127 aa)
PDK1Protein-serine/threonine kinase. (389 aa)
CYBACytochrome b-245 alpha chain. (169 aa)
NDUFB6NADH:ubiquinone oxidoreductase subunit B6. (127 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (408 aa)
FOXRED1FAD dependent oxidoreductase domain containing 1. (486 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
NDUFC1Uncharacterized protein. (76 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (275 aa)
UQCR10Ubiquinol-cytochrome c reductase, complex III subunit X. (64 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (349 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
XDHXanthine dehydrogenase. (1316 aa)
GLOD5Glyoxalase domain containing 5. (148 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
CYBBCytochrome b-245 beta chain. (571 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
NOX3NADPH oxidase 3. (572 aa)
OGDHOxoglutarate dehydrogenase. (1034 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (727 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (350 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (621 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (330 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (252 aa)
NDUFS4Uncharacterized protein. (83 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (316 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family. (450 aa)
GCSHGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (171 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
G3TFW7_LOXAFGlutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
HAO1Hydroxyacid oxidase 1. (371 aa)
CBR4Carbonyl reductase 4. (237 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
NOX4NADPH oxidase 4. (579 aa)
DUOX2Dual oxidase 2. (1541 aa)
DUOX1Dual oxidase 1. (1552 aa)
NCF1Neutrophil cytosolic factor 1. (409 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (262 aa)
NDUFA3NADH:ubiquinone oxidoreductase subunit A3. (84 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa)
NDUFA7Uncharacterized protein. (114 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
ETFBElectron transfer flavoprotein subunit beta. (256 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
NDUFB4NADH:ubiquinone oxidoreductase subunit B4. (130 aa)
DHDHDihydrodiol dehydrogenase. (332 aa)
DMAC2Distal membrane arm assembly complex 2. (258 aa)
NDUFA9Uncharacterized protein. (157 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (489 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (95 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (138 aa)
PSTKPhosphoseryl-tRNA kinase. (359 aa)
BCKDHA2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (449 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (388 aa)
CYB5BCytochrome b5 type B; Belongs to the cytochrome b5 family. (148 aa)
ALKBH6Uncharacterized protein. (91 aa)
G3UFM1_LOXAFUncharacterized protein. (46 aa)
G3UH69_LOXAFzf-CHCC domain-containing protein. (119 aa)
PDHA1E1_dh domain-containing protein. (392 aa)
LOC104846773Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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