(71 nodes) Death-like domain superfamily network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANKDD1A	Ankyrin repeat and death domain containing 1A. (470 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (973 aa)
	THOC1	THO complex 1. (657 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1006 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (672 aa)
	UNC5C	Unc-5 netrin receptor C. (950 aa)
	G3T690_LOXAF	Uncharacterized protein. (637 aa)
	NLRP6	Uncharacterized protein. (732 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1020 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (450 aa)
	TNFRSF21	TNF receptor superfamily member 21. (657 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (707 aa)
	G3TH08_LOXAF	CARD domain-containing protein. (89 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (425 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	UNC5CL	Unc-5 family C-terminal like. (515 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (478 aa)
	MALT1	MALT1 paracaspase. (834 aa)
	ANKDD1B	Ankyrin repeat and death domain containing 1B. (469 aa)
	EDARADD	EDAR associated death domain. (206 aa)
	G3TMS6_LOXAF	Uncharacterized protein; Belongs to the peptidase C14A family. (377 aa)
	CASP12	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (412 aa)
	CARD19	Caspase recruitment domain family member 19. (183 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	CARD9	Caspase recruitment domain family member 9. (537 aa)
	ANK3	Ankyrin 3. (4346 aa)
	DAPK1	Death associated protein kinase 1. (1444 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
	NLRP12	NLR family pyrin domain containing 12. (991 aa)
	MNDA	Myeloid cell nuclear differentiation antigen. (399 aa)
	CARD10	Caspase recruitment domain family member 10. (1026 aa)
	PIDD1	P53-induced death domain protein 1. (917 aa)
	UNC5A	Unc-5 netrin receptor A. (886 aa)
	G3TWQ7_LOXAF	Uncharacterized protein. (273 aa)
	DEDD2	Death effector domain containing 2. (319 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
	G3U5N1_LOXAF	Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (293 aa)
	G3U7Y9_LOXAF	Death domain-containing protein. (231 aa)
	ANK1	Ankyrin 1. (1827 aa)
	NOL3	Nucleolar protein 3. (188 aa)
	G3UEE5_LOXAF	Uncharacterized protein. (1434 aa)
	NLRP9	NLR family pyrin domain containing 9. (972 aa)
	EDAR	Ectodysplasin A receptor. (438 aa)
	NLRP3	NLR family pyrin domain containing 3. (1025 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (459 aa)
	NLRP2	NLR family pyrin domain containing 2. (1047 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
	G3SQ64_LOXAF	Uncharacterized protein. (193 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (626 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (606 aa)
	MAVS	Mitochondrial antiviral signaling protein. (516 aa)
	CARD6	Caspase recruitment domain family member 6. (927 aa)
	CARD8	Uncharacterized protein. (394 aa)
	NGFR	Nerve growth factor receptor. (414 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	CARD11	Caspase recruitment domain family member 11. (1159 aa)
	UNC5D	Unc-5 netrin receptor D. (926 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	UNC5B	Unc-5 netrin receptor B. (937 aa)
	DDX58	DExD/H-box helicase 58. (934 aa)
	PYCARD	PYD and CARD domain containing. (199 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (603 aa)
	DEDD	Death effector domain containing. (318 aa)
	TRADD	TNFRSF1A associated via death domain. (310 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (896 aa)
	NLRP11	Uncharacterized protein. (669 aa)
	G3SZN4_LOXAF	Uncharacterized protein. (297 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (588 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK1	ANK3	ENSLAFP00000024658	ENSLAFP00000017581	Ankyrin 1.	Ankyrin 3.	0.900
ANK3	ANK1	ENSLAFP00000017581	ENSLAFP00000024658	Ankyrin 3.	Ankyrin 1.	0.900
APAF1	BIRC2	ENSLAFP00000012269	ENSLAFP00000002461	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.643
APAF1	BIRC3	ENSLAFP00000012269	ENSLAFP00000005074	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 3.	0.643
APAF1	CARD8	ENSLAFP00000012269	ENSLAFP00000002966	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.684
APAF1	CASP12	ENSLAFP00000012269	ENSLAFP00000016706	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.	0.752
APAF1	CASP2	ENSLAFP00000012269	ENSLAFP00000004205	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.842
APAF1	CASP8	ENSLAFP00000012269	ENSLAFP00000015318	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.802
APAF1	CASP9	ENSLAFP00000012269	ENSLAFP00000013219	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSLAFP00000012269	ENSLAFP00000017835	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.703
APAF1	G3SQ64_LOXAF	ENSLAFP00000012269	ENSLAFP00000001915	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.735
APAF1	G3TH08_LOXAF	ENSLAFP00000012269	ENSLAFP00000013808	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CARD domain-containing protein.	0.684
APAF1	G3TMS6_LOXAF	ENSLAFP00000012269	ENSLAFP00000016445	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.684
APAF1	G3U5N1_LOXAF	ENSLAFP00000012269	ENSLAFP00000023139	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.735
APAF1	NOD1	ENSLAFP00000012269	ENSLAFP00000009438	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Nucleotide binding oligomerization domain containing 1.	0.407
APAF1	PEA15	ENSLAFP00000012269	ENSLAFP00000017358	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Proliferation and apoptosis adaptor protein 15.	0.684
APAF1	PIDD1	ENSLAFP00000012269	ENSLAFP00000018636	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53-induced death domain protein 1.	0.407
BCL10	CARD11	ENSLAFP00000003045	ENSLAFP00000003881	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.819
BCL10	CASP8	ENSLAFP00000003045	ENSLAFP00000015318	BCL10 immune signaling adaptor.	Caspase 8; Belongs to the peptidase C14A family.	0.900
BCL10	MALT1	ENSLAFP00000003045	ENSLAFP00000015402	BCL10 immune signaling adaptor.	MALT1 paracaspase.	0.956

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