STRINGSTRING
GLA GLA ALAD ALAD IMPDH1 IMPDH1 MOCS1 MOCS1 ALDOB ALDOB ALDOC ALDOC QPRT QPRT HAO2 HAO2 HOGA1 HOGA1 HYAL1 HYAL1 LIAS LIAS IMPDH2 IMPDH2 NAGA NAGA GMPR2 GMPR2 DUS2 DUS2 DERA DERA GMPR GMPR HAO1 HAO1 RSAD2 RSAD2 HMGCL HMGCL ALDOA ALDOA HMGCLL1 HMGCLL1 RPE RPE G3TPT4_LOXAF G3TPT4_LOXAF TPI1 TPI1 DUS3L DUS3L HYAL2 HYAL2 DHODH DHODH NPL NPL G3UEQ2_LOXAF G3UEQ2_LOXAF NAMPT NAMPT HYAL3 HYAL3 HYAL4 HYAL4 RSAD1 RSAD1 GALC GALC TALDO1 TALDO1 UMPS UMPS SPAM1 SPAM1 DUS1L DUS1L NANS NANS DPYD DPYD PC PC DUS4L DUS4L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLAAlpha-galactosidase. (422 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (331 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (509 aa)
MOCS1Molybdenum cofactor synthesis 1. (635 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
HAO2Hydroxyacid oxidase 2. (353 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
HYAL1Hyaluronidase. (435 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
NAGAAlpha-galactosidase. (411 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (350 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
DERADeoxyribose-phosphate aldolase. (320 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (316 aa)
HAO1Hydroxyacid oxidase 1. (371 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (366 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
G3TPT4_LOXAFFlavodoxin-like domain-containing protein. (567 aa)
TPI1Triosephosphate isomerase. (249 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (658 aa)
HYAL2Hyaluronidase. (475 aa)
DHODHDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (397 aa)
NPLN-acetylneuraminate pyruvate lyase; Belongs to the DapA family. (320 aa)
G3UEQ2_LOXAFHyaluronidase. (493 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (497 aa)
HYAL3Hyaluronidase. (410 aa)
HYAL4Hyaluronidase. (481 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
GALCGalactosylceramidase. (683 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (305 aa)
UMPSUridine monophosphate synthetase. (482 aa)
SPAM1Uncharacterized protein. (135 aa)
DUS1LDihydrouridine synthase 1 like. (484 aa)
NANSN-acetylneuraminate synthase. (358 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
PCPyruvate carboxylase. (1039 aa)
DUS4LtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (316 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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