(72 nodes) Dbl homology (DH) domain superfamily network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3U095_LOXAF	Uncharacterized protein. (367 aa)
	ARHGEF5	Uncharacterized protein. (380 aa)
	ARHGEF33	DH domain-containing protein. (366 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (946 aa)
	FGD3	FYVE, RhoGEF and PH domain containing 3. (727 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (847 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (964 aa)
	FGD4	FYVE, RhoGEF and PH domain containing 4. (766 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1250 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1601 aa)
	PLEKHG4	Uncharacterized protein. (521 aa)
	FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1046 aa)
	FGD6	FYVE, RhoGEF and PH domain containing 6. (1435 aa)
	SPATA13	Uncharacterized protein. (652 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor 40. (1517 aa)
	ECT2	Epithelial cell transforming 2. (873 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1212 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3038 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1037 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (704 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (866 aa)
	FGD5	FYVE, RhoGEF and PH domain containing 5. (1538 aa)
	AKAP13	Uncharacterized protein. (2466 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
	ALS2CL	ALS2 C-terminal like. (952 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (988 aa)
	G3T7H6_LOXAF	Uncharacterized protein. (376 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1590 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1558 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1105 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (693 aa)
	ITSN2	Intersectin 2. (1297 aa)
	PLEKHG7	Chromosome 12 open reading frame 74. (379 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (530 aa)
	KALRN	Uncharacterized protein. (1705 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1356 aa)
	PLEKHG1	Pleckstrin homology and RhoGEF domain containing G1. (1391 aa)
	G3SSL0_LOXAF	PH domain-containing protein. (748 aa)
	ECT2L	Epithelial cell transforming 2 like. (905 aa)
	PLEKHG6	Pleckstrin homology and RhoGEF domain containing G6. (793 aa)
	NET1	Uncharacterized protein. (596 aa)
	FGD2	FYVE, RhoGEF and PH domain containing 2. (656 aa)
	OBSCN	Uncharacterized protein. (834 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor 39. (331 aa)
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (489 aa)
	G3TR06_LOXAF	Uncharacterized protein. (532 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (640 aa)
	PLEKHG4B	Uncharacterized protein. (469 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (977 aa)
	ABR	ABR activator of RhoGEF and GTPase. (871 aa)
	ARHGEF28	Rho guanine nucleotide exchange factor 28. (1673 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1160 aa)
	DNMBP	Dynamin binding protein. (1606 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (785 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1276 aa)
	G3UC96_LOXAF	Uncharacterized protein. (502 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (861 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (858 aa)
	ITSN1	Intersectin 1. (1719 aa)
	ARHGEF17	Rho guanine nucleotide exchange factor 17. (2055 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1658 aa)
	ARHGEF38	DH domain-containing protein. (219 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1258 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (675 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1452 aa)
	ARHGEF25	Uncharacterized protein. (619 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1723 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1042 aa)
	ARHGEF9	Cdc42 guanine nucleotide exchange factor 9. (551 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	G3SSL0_LOXAF	ENSLAFP00000029082	ENSLAFP00000002948	ABR activator of RhoGEF and GTPase.	PH domain-containing protein.	0.447
ABR	TIAM1	ENSLAFP00000029082	ENSLAFP00000000358	ABR activator of RhoGEF and GTPase.	T cell lymphoma invasion and metastasis 1.	0.417
AKAP13	ARHGEF11	ENSLAFP00000008821	ENSLAFP00000000457	Uncharacterized protein.	Rho guanine nucleotide exchange factor 11.	0.928
AKAP13	ARHGEF12	ENSLAFP00000008821	ENSLAFP00000011123	Uncharacterized protein.	Rho guanine nucleotide exchange factor 12.	0.934
AKAP13	ARHGEF16	ENSLAFP00000008821	ENSLAFP00000008441	Uncharacterized protein.	Rho guanine nucleotide exchange factor 16.	0.406
AKAP13	G3U095_LOXAF	ENSLAFP00000008821	ENSLAFP00000021253	Uncharacterized protein.	Uncharacterized protein.	0.453
AKAP13	ITSN1	ENSLAFP00000008821	ENSLAFP00000021669	Uncharacterized protein.	Intersectin 1.	0.433
AKAP13	ITSN2	ENSLAFP00000008821	ENSLAFP00000000522	Uncharacterized protein.	Intersectin 2.	0.453
AKAP13	TRIO	ENSLAFP00000008821	ENSLAFP00000006607	Uncharacterized protein.	Trio Rho guanine nucleotide exchange factor.	0.412
ALS2	ALS2CL	ENSLAFP00000009989	ENSLAFP00000009115	Alsin Rho guanine nucleotide exchange factor ALS2.	ALS2 C-terminal like.	0.447
ALS2	ARHGEF16	ENSLAFP00000009989	ENSLAFP00000008441	Alsin Rho guanine nucleotide exchange factor ALS2.	Rho guanine nucleotide exchange factor 16.	0.592
ALS2CL	ALS2	ENSLAFP00000009115	ENSLAFP00000009989	ALS2 C-terminal like.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.447
ARHGEF1	ARHGEF17	ENSLAFP00000020322	ENSLAFP00000021385	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 17.	0.425
ARHGEF1	ARHGEF25	ENSLAFP00000020322	ENSLAFP00000011346	Rho guanine nucleotide exchange factor 1.	Uncharacterized protein.	0.412
ARHGEF1	ECT2	ENSLAFP00000020322	ENSLAFP00000006546	Rho guanine nucleotide exchange factor 1.	Epithelial cell transforming 2.	0.501
ARHGEF1	FGD1	ENSLAFP00000020322	ENSLAFP00000015169	Rho guanine nucleotide exchange factor 1.	FYVE, RhoGEF and PH domain containing 1.	0.426
ARHGEF1	G3U095_LOXAF	ENSLAFP00000020322	ENSLAFP00000021253	Rho guanine nucleotide exchange factor 1.	Uncharacterized protein.	0.457
ARHGEF1	ITSN1	ENSLAFP00000020322	ENSLAFP00000021669	Rho guanine nucleotide exchange factor 1.	Intersectin 1.	0.437
ARHGEF1	ITSN2	ENSLAFP00000020322	ENSLAFP00000000522	Rho guanine nucleotide exchange factor 1.	Intersectin 2.	0.457
ARHGEF1	MCF2	ENSLAFP00000020322	ENSLAFP00000014213	Rho guanine nucleotide exchange factor 1.	MCF.2 cell line derived transforming sequence.	0.593

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