STRINGSTRING
N4BP1 N4BP1 PPP2R1A PPP2R1A MAP3K20 MAP3K20 PPP2CA PPP2CA DUSP3 DUSP3 IRAK1 IRAK1 KHNYN KHNYN UBE2V1 UBE2V1 RPS6KA2 RPS6KA2 NLRP9 NLRP9 G3ULI4_LOXAF G3ULI4_LOXAF UBC UBC G3UKV2_LOXAF G3UKV2_LOXAF ATF1 ATF1 RELA RELA MAPK9 MAPK9 NKIRAS2 NKIRAS2 MAPKAPK3 MAPKAPK3 ECSIT ECSIT CREB5 CREB5 UBB UBB PELI3 PELI3 ATF7 ATF7 IRAK2 IRAK2 G3SQ64_LOXAF G3SQ64_LOXAF VRK3 VRK3 MAP3K1 MAP3K1 S100A12 S100A12 G3SLR0_LOXAF G3SLR0_LOXAF HMGB1 HMGB1 TAB3 TAB3 NOD1 NOD1 RPS27A RPS27A TONSL TONSL DUSP6 DUSP6 NLRP6 NLRP6 AGER AGER LRRC34 LRRC34 PELI1 PELI1 MAPK7 MAPK7 MAPK1 MAPK1 USP14 USP14 LRRC14 LRRC14 TIFA TIFA NFKB1 NFKB1 FOSL2 FOSL2 RPS6KA4 RPS6KA4 VWC2 VWC2 TMEM189 TMEM189 RPS6KA3 RPS6KA3 NFKB2 NFKB2 ATF2 ATF2 G3SXT2_LOXAF G3SXT2_LOXAF MAPK14 MAPK14 MAP2K7 MAP2K7 RPS6KA1 RPS6KA1 USP18 USP18 MAP2K6 MAP2K6 IKBKB IKBKB NKIRAS1 NKIRAS1 NLRC5 NLRC5 APP APP RELCH RELCH PELI2 PELI2 G3TWH0_LOXAF G3TWH0_LOXAF TRAF6 TRAF6 PPP2R1B PPP2R1B IKBKG IKBKG VWC2L VWC2L UBA52 UBA52 LRRC71 LRRC71 LOC100676713 LOC100676713 DUSP7 DUSP7 JUN JUN MAPKAPK2 MAPKAPK2 RPS6KA5 RPS6KA5 MAPK3 MAPK3 UBE2N UBE2N CASP8 CASP8 MAP3K7 MAP3K7 NFKBIA NFKBIA NFKBIB NFKBIB MAPK8 MAPK8 FOS FOS TAB1 TAB1 ELK1 ELK1 FNBP4 FNBP4 ALPK1 ALPK1 CHUK CHUK S100B S100B PPP4R4 PPP4R4 LRRC31 LRRC31 NOD2 NOD2 MAP2K4 MAP2K4 CREB1 CREB1 PPP4R1 PPP4R1 MAPK10 MAPK10 G3U9C8_LOXAF G3U9C8_LOXAF PPP2CB PPP2CB TAB2 TAB2 LRRC74B LRRC74B MAP2K3 MAP2K3 G3U6P2_LOXAF G3U6P2_LOXAF G3U5N1_LOXAF G3U5N1_LOXAF RIPK2 RIPK2 G3U2U4_LOXAF G3U2U4_LOXAF NLRX1 NLRX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
N4BP1NEDD4 binding protein 1. (825 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MAP3K20Protein kinase domain-containing protein. (743 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (190 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
KHNYNKH and NYN domain containing. (660 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
RPS6KA2Ribosomal protein S6 kinase. (737 aa)
NLRP9NLR family pyrin domain containing 9. (972 aa)
G3ULI4_LOXAFUncharacterized protein; Belongs to the peptidase C14A family. (223 aa)
UBCUncharacterized protein. (381 aa)
G3UKV2_LOXAFCCHC NOA-type domain-containing protein. (353 aa)
ATF1Uncharacterized protein. (270 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
MAPKAPK3MAPK activated protein kinase 3. (385 aa)
ECSITECSIT signalling integrator. (406 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
UBBUbiquitin B. (305 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (447 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (626 aa)
G3SQ64_LOXAFUncharacterized protein. (193 aa)
VRK3VRK serine/threonine kinase 3. (457 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1497 aa)
S100A12Protein S100; Belongs to the S-100 family. (96 aa)
G3SLR0_LOXAFUncharacterized protein. (244 aa)
HMGB1Uncharacterized protein. (215 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
RPS27AUbiquitin-like domain-containing protein. (144 aa)
TONSLTonsoku like, DNA repair protein. (1364 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (380 aa)
NLRP6Uncharacterized protein. (732 aa)
AGERAdvanced glycosylation end-product specific receptor. (402 aa)
LRRC34Leucine rich repeat containing 34. (415 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (801 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
LRRC14Leucine rich repeat containing 14. (495 aa)
TIFATRAF interacting protein with forkhead associated domain. (182 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
VWC2Von Willebrand factor C domain containing 2. (328 aa)
TMEM189Transmembrane protein 189. (271 aa)
RPS6KA3Ribosomal protein S6 kinase. (737 aa)
NFKB2Nuclear factor kappa B subunit 2. (896 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (487 aa)
G3SXT2_LOXAFUncharacterized protein. (787 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (703 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (374 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
NLRC5Uncharacterized protein. (1105 aa)
APPAmyloid beta precursor protein. (751 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1213 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
G3TWH0_LOXAFSerine/threonine-protein phosphatase. (285 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (697 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
LRRC71Leucine rich repeat containing 71. (561 aa)
LOC100676713UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
MAPKAPK2MAPK activated protein kinase 2. (308 aa)
RPS6KA5Ribosomal protein S6 kinase. (730 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (478 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKBIBNFKB inhibitor beta. (355 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (316 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (506 aa)
ELK1ETS transcription factor ELK1. (431 aa)
FNBP4Formin binding protein 4. (1064 aa)
ALPK1Alpha kinase 1. (1230 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (875 aa)
LRRC31Leucine rich repeat containing 31. (557 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1020 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (326 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (927 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
G3U9C8_LOXAFUbiquitin-like domain-containing protein. (172 aa)
PPP2CBSerine/threonine-protein phosphatase. (276 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LRRC74BLeucine rich repeat containing 74B. (342 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
G3U6P2_LOXAFMetallophos domain-containing protein. (98 aa)
G3U5N1_LOXAFUncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
G3U2U4_LOXAFSerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
NLRX1NLR family member X1. (978 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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