(63 nodes) PRC2 methylates histones and DNA network (Loxodonta africana)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC100672618	Histone H3; Belongs to the histone H3 family. (136 aa)
	H2BC21	Histone H2B; Belongs to the histone H2B family. (126 aa)
	G3UNK7_LOXAF	Histone H2B; Belongs to the histone H2B family. (134 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	ENSLAFP00000028516	annotation not available (136 aa)
	G3UKU6_LOXAF	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
	ENSLAFP00000028190	annotation not available (104 aa)
	ENSLAFP00000028008	annotation not available (126 aa)
	ENSLAFP00000027955	annotation not available (103 aa)
	ENSLAFP00000027938	annotation not available (103 aa)
	ENSLAFP00000027918	annotation not available (126 aa)
	ENSLAFP00000027715	annotation not available (136 aa)
	ENSLAFP00000026689	annotation not available (136 aa)
	LOC100658484	Histone H3; Belongs to the histone H3 family. (136 aa)
	H2BC18	Histone H2B; Belongs to the histone H2B family. (126 aa)
	ENSLAFP00000025084	annotation not available (136 aa)
	H2BC3	Histone H2B; Belongs to the histone H2B family. (126 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	G3U9V5_LOXAF	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
	G3U8T3_LOXAF	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
	LOC100665018	Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
	ENSLAFP00000023559	annotation not available (136 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
	H2BC12	Histone H2B; Belongs to the histone H2B family. (135 aa)
	ENSLAFP00000022963	annotation not available (103 aa)
	ENSLAFP00000022732	annotation not available (103 aa)
	ENSLAFP00000022709	annotation not available (126 aa)
	ENSLAFP00000022509	annotation not available (126 aa)
	G3U1Z3_LOXAF	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
	H2BC5	Histone H2B; Belongs to the histone H2B family. (126 aa)
	LOC100660148	Histone H2B; Belongs to the histone H2B family. (126 aa)
	EED	Embryonic ectoderm development. (510 aa)
	H2BC11	Histone H2B; Belongs to the histone H2B family. (135 aa)
	ENSLAFP00000019836	annotation not available (136 aa)
	H4C11	H4 clustered histone 11. (103 aa)
	ENSLAFP00000019049	annotation not available (136 aa)
	ENSLAFP00000018749	annotation not available (136 aa)
	H2AZ1	Histone H2A; Belongs to the histone H2A family. (128 aa)
	ENSLAFP00000018530	annotation not available (103 aa)
	LOC111752373	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100657920	Histone H2B; Belongs to the histone H2B family. (126 aa)
	ENSLAFP00000016544	annotation not available (136 aa)
	ENSLAFP00000016306	annotation not available (103 aa)
	AEBP2	AE binding protein 2. (494 aa)
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (855 aa)
	G5E6Z7_LOXAF	Histone domain-containing protein. (129 aa)
	MTF2	Metal response element binding transcription factor 2. (593 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (426 aa)
	LOC100675119	Histone H2B; Belongs to the histone H2B family. (127 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1236 aa)
	LOC100669973	Histone H2B; Belongs to the histone H2B family. (126 aa)
	H2AZ2	Histone H2A; Belongs to the histone H2A family. (127 aa)
	PHF1	PHD finger protein 1. (571 aa)
	LOC100662145	Histone H2B; Belongs to the histone H2B family. (126 aa)
	LOC111752376	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	PHF19	PHD finger protein 19. (579 aa)
	HIST1H2BA	Histone cluster 1 H2B family member a; Belongs to the histone H2B family. (127 aa)
	LOC100661012	Histone H2B; Belongs to the histone H2B family. (126 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa)
	RBBP4	RB binding protein 4, chromatin remodeling factor. (425 aa)
	LOC100655240	Histone domain-containing protein. (136 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEBP2	DNMT1	ENSLAFP00000015802	ENSLAFP00000002359	AE binding protein 2.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.531
AEBP2	DNMT3A	ENSLAFP00000015802	ENSLAFP00000023469	AE binding protein 2.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.402
AEBP2	DNMT3B	ENSLAFP00000015802	ENSLAFP00000014230	AE binding protein 2.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.406
AEBP2	EED	ENSLAFP00000015802	ENSLAFP00000021138	AE binding protein 2.	Embryonic ectoderm development.	0.987
AEBP2	ENSLAFP00000016544	ENSLAFP00000015802	ENSLAFP00000016544	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000018749	ENSLAFP00000015802	ENSLAFP00000018749	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000019049	ENSLAFP00000015802	ENSLAFP00000019049	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000019836	ENSLAFP00000015802	ENSLAFP00000019836	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000022509	ENSLAFP00000015802	ENSLAFP00000022509	AE binding protein 2.	annotation not available	0.422
AEBP2	ENSLAFP00000022709	ENSLAFP00000015802	ENSLAFP00000022709	AE binding protein 2.	annotation not available	0.422
AEBP2	ENSLAFP00000023559	ENSLAFP00000015802	ENSLAFP00000023559	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000025084	ENSLAFP00000015802	ENSLAFP00000025084	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000026689	ENSLAFP00000015802	ENSLAFP00000026689	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000027715	ENSLAFP00000015802	ENSLAFP00000027715	AE binding protein 2.	annotation not available	0.431
AEBP2	ENSLAFP00000027918	ENSLAFP00000015802	ENSLAFP00000027918	AE binding protein 2.	annotation not available	0.422
AEBP2	ENSLAFP00000028008	ENSLAFP00000015802	ENSLAFP00000028008	AE binding protein 2.	annotation not available	0.422
AEBP2	ENSLAFP00000028190	ENSLAFP00000015802	ENSLAFP00000028190	AE binding protein 2.	annotation not available	0.404
AEBP2	ENSLAFP00000028516	ENSLAFP00000015802	ENSLAFP00000028516	AE binding protein 2.	annotation not available	0.431
AEBP2	EZH1	ENSLAFP00000015802	ENSLAFP00000008734	AE binding protein 2.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.971
AEBP2	EZH2	ENSLAFP00000015802	ENSLAFP00000001317	AE binding protein 2.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.981

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