STRINGSTRING
G3TR32_LOXAF G3TR32_LOXAF UBA52 UBA52 CBX7 CBX7 LOC100657920 LOC100657920 RING1 RING1 CDKN2B CDKN2B ENSLAFP00000016306 ENSLAFP00000016306 JUN JUN NPTXR NPTXR MAPKAPK2 MAPKAPK2 CDK6 CDK6 MAPKAPK5 MAPKAPK5 TNIK TNIK G3TI55_LOXAF G3TI55_LOXAF G3THQ5_LOXAF G3THQ5_LOXAF MINK1 MINK1 RBBP7 RBBP7 MAP2K4 MAP2K4 MAP3K5 MAP3K5 EZH2 EZH2 NRK NRK MDM4 MDM4 RBBP4 RBBP4 LOC100661012 LOC100661012 HIST1H2BA HIST1H2BA MAP2K6 MAP2K6 MAP2K7 MAP2K7 G3SVD7_LOXAF G3SVD7_LOXAF MAPK14 MAPK14 LOC111752376 LOC111752376 LOC100662145 LOC100662145 MAP4K4 MAP4K4 NME8 NME8 MAP3K6 MAP3K6 H2AZ2 H2AZ2 LOC100669973 LOC100669973 CBX8 CBX8 TP53 TP53 NPTX2 NPTX2 FOSL2 FOSL2 CDKN2C CDKN2C MAPK1 MAPK1 EZH1 EZH1 CDK4 CDK4 LOC100675119 LOC100675119 SCML2 SCML2 MAPK10 MAPK10 TXN TXN SCMH1 SCMH1 G3UI57_LOXAF G3UI57_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UHE5_LOXAF G3UHE5_LOXAF MAPK9 MAPK9 MAPKAPK3 MAPKAPK3 G3UDE4_LOXAF G3UDE4_LOXAF G3UD01_LOXAF G3UD01_LOXAF H2BC18 H2BC18 G3UNK7_LOXAF G3UNK7_LOXAF MAPK3 MAPK3 SUZ12 SUZ12 G3ULT4_LOXAF G3ULT4_LOXAF H2BC21 H2BC21 PHC3 PHC3 NPTX1 NPTX1 G3UKU6_LOXAF G3UKU6_LOXAF ENSLAFP00000028190 ENSLAFP00000028190 G3UK14_LOXAF G3UK14_LOXAF ENSLAFP00000028008 ENSLAFP00000028008 ENSLAFP00000027955 ENSLAFP00000027955 ENSLAFP00000027938 ENSLAFP00000027938 ENSLAFP00000027918 ENSLAFP00000027918 G3UJ00_LOXAF G3UJ00_LOXAF G3UB93_LOXAF G3UB93_LOXAF G3UAZ0_LOXAF G3UAZ0_LOXAF H2BC3 H2BC3 MAPK8 MAPK8 G3U9V5_LOXAF G3U9V5_LOXAF FOS FOS G3U9C8_LOXAF G3U9C8_LOXAF CDKN2D CDKN2D G3U8T3_LOXAF G3U8T3_LOXAF LOC100665018 LOC100665018 TXNDC8 TXNDC8 G3U6U6_LOXAF G3U6U6_LOXAF MAP2K3 MAP2K3 G3U6D1_LOXAF G3U6D1_LOXAF H2BC12 H2BC12 ENSLAFP00000022963 ENSLAFP00000022963 ENSLAFP00000022732 ENSLAFP00000022732 ENSLAFP00000022709 ENSLAFP00000022709 ENSLAFP00000022509 ENSLAFP00000022509 RNF2 RNF2 G3U1Z3_LOXAF G3U1Z3_LOXAF H2BC5 H2BC5 RPS27A RPS27A LOC100660148 LOC100660148 EED EED H2BC11 H2BC11 PHC1 PHC1 PHC2 PHC2 TXNDC2 TXNDC2 H4C11 H4C11 ENSLAFP00000019204 ENSLAFP00000019204 LOC100675676 LOC100675676 H2AZ1 H2AZ1 ENSLAFP00000018530 ENSLAFP00000018530 NME9 NME9 G3TS21_LOXAF G3TS21_LOXAF CBX2 CBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3TR32_LOXAFSAM domain-containing protein. (508 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CBX7Chromobox 7. (248 aa)
LOC100657920Histone H2B; Belongs to the histone H2B family. (126 aa)
RING1Ring finger protein 1. (406 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
ENSLAFP00000016306annotation not available (103 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
NPTXRChromo domain-containing protein. (680 aa)
MAPKAPK2MAPK activated protein kinase 2. (308 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
TNIKTRAF2 and NCK interacting kinase. (1269 aa)
G3TI55_LOXAFSAM domain-containing protein. (330 aa)
G3THQ5_LOXAFRING-type domain-containing protein. (330 aa)
MINK1Misshapen like kinase 1. (1341 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (426 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (326 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
NRKNik related kinase. (1285 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
LOC100661012Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BAHistone cluster 1 H2B family member a; Belongs to the histone H2B family. (127 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
G3SVD7_LOXAFUncharacterized protein. (241 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111752376Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC100662145Histone H2B; Belongs to the histone H2B family. (126 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1254 aa)
NME8NME/NM23 family member 8. (591 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1279 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (127 aa)
LOC100669973Histone H2B; Belongs to the histone H2B family. (126 aa)
CBX8Chromobox 8. (365 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
NPTX2Neuronal pentraxin 2. (432 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (226 aa)
LOC100675119Histone H2B; Belongs to the histone H2B family. (127 aa)
SCML2Uncharacterized protein. (125 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
TXNThioredoxin. (98 aa)
SCMH1SAM domain-containing protein. (662 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
MAPKAPK3MAPK activated protein kinase 3. (385 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
G3UD01_LOXAFUncharacterized protein. (743 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
G3UNK7_LOXAFHistone H2B; Belongs to the histone H2B family. (134 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
PHC3Polyhomeotic homolog 3. (980 aa)
NPTX1Neuronal pentraxin 1. (285 aa)
G3UKU6_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
ENSLAFP00000028190annotation not available (104 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
ENSLAFP00000028008annotation not available (126 aa)
ENSLAFP00000027955annotation not available (103 aa)
ENSLAFP00000027938annotation not available (103 aa)
ENSLAFP00000027918annotation not available (126 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UB93_LOXAFRAWUL domain-containing protein. (334 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
G3U9V5_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (316 aa)
G3U9C8_LOXAFUbiquitin-like domain-containing protein. (172 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
G3U8T3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
LOC100665018Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
TXNDC8Thioredoxin domain containing 8. (119 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (135 aa)
ENSLAFP00000022963annotation not available (103 aa)
ENSLAFP00000022732annotation not available (103 aa)
ENSLAFP00000022709annotation not available (126 aa)
ENSLAFP00000022509annotation not available (126 aa)
RNF2RING-type domain-containing protein. (308 aa)
G3U1Z3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
RPS27AUbiquitin-like domain-containing protein. (144 aa)
LOC100660148Histone H2B; Belongs to the histone H2B family. (126 aa)
EEDEmbryonic ectoderm development. (510 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (135 aa)
PHC1Polyhomeotic homolog 1. (1013 aa)
PHC2Polyhomeotic homolog 2. (948 aa)
TXNDC2Thioredoxin; Belongs to the thioredoxin family. (105 aa)
H4C11H4 clustered histone 11. (103 aa)
ENSLAFP00000019204annotation not available (127 aa)
LOC100675676Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSLAFP00000018530annotation not available (103 aa)
NME9NME/NM23 family member 9; Belongs to the NDK family. (301 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
CBX2Chromobox 2. (486 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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