STRINGSTRING
CDKN1B CDKN1B G3UHE5_LOXAF G3UHE5_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UI57_LOXAF G3UI57_LOXAF ENSLAFP00000027715 ENSLAFP00000027715 G3UJ00_LOXAF G3UJ00_LOXAF ENSLAFP00000027918 ENSLAFP00000027918 ENSLAFP00000027938 ENSLAFP00000027938 ENSLAFP00000027955 ENSLAFP00000027955 ENSLAFP00000028008 ENSLAFP00000028008 ETV3L ETV3L G3UK14_LOXAF G3UK14_LOXAF ENSLAFP00000028190 ENSLAFP00000028190 G3UKU6_LOXAF G3UKU6_LOXAF NPTX1 NPTX1 PHC3 PHC3 ENSLAFP00000028516 ENSLAFP00000028516 H2BC21 H2BC21 UBC UBC TLX2 TLX2 G3ULT4_LOXAF G3ULT4_LOXAF RPS6KA2 RPS6KA2 SUZ12 SUZ12 MAPK3 MAPK3 G3UNK7_LOXAF G3UNK7_LOXAF H1-6 H1-6 MAP3K5 MAP3K5 UBE2D1 UBE2D1 CCNA1 CCNA1 HLX HLX CCNE2 CCNE2 H1-0 H1-0 EZH2 EZH2 NRK NRK MDM4 MDM4 LOC100655240 LOC100655240 RBBP4 RBBP4 UBE2C UBE2C UBN1 UBN1 CDC16 CDC16 LOC100661012 LOC100661012 TLX1 TLX1 TERF1 TERF1 HIST1H2BA HIST1H2BA ETS2 ETS2 BARHL2 BARHL2 ANAPC2 ANAPC2 MAP2K6 MAP2K6 TERF2 TERF2 RPS6KA1 RPS6KA1 DBX2 DBX2 MAP2K7 MAP2K7 G3SVD7_LOXAF G3SVD7_LOXAF MAPK14 MAPK14 LOC111752376 LOC111752376 H1-5 H1-5 LOC100662145 LOC100662145 CDC23 CDC23 MAP4K4 MAP4K4 POT1 POT1 BARX2 BARX2 NME8 NME8 MAP3K6 MAP3K6 ANAPC7 ANAPC7 H2AZ2 H2AZ2 H1-3 H1-3 ETV3 ETV3 RPS6KA3 RPS6KA3 LOC100669973 LOC100669973 ACD ACD DBX1 DBX1 CBX8 CBX8 TP53 TP53 ANAPC5 ANAPC5 LOC100672618 LOC100672618 EHMT2 EHMT2 ATM ATM CDC26 CDC26 NPTX2 NPTX2 FOSL2 FOSL2 ANAPC10 ANAPC10 CDKN2C CDKN2C CCNA2 CCNA2 RAD50 RAD50 MAPK1 MAPK1 MAPK7 MAPK7 EZH1 EZH1 CDK4 CDK4 FAM89B FAM89B CABIN1 CABIN1 HIRA HIRA LOC100675119 LOC100675119 CDC27 CDC27 EHMT1 EHMT1 SCML2 SCML2 CCNE1 CCNE1 MAPK10 MAPK10 ANAPC4 ANAPC4 TM7SF3 TM7SF3 TXN TXN SCMH1 SCMH1 MAP2K4 MAP2K4 RBBP7 RBBP7 TINF2 TINF2 ASF1A ASF1A EP400 EP400 MINK1 MINK1 BARHL1 BARHL1 KAT5 KAT5 G5E6Z7_LOXAF G5E6Z7_LOXAF SRCAP SRCAP G3THQ5_LOXAF G3THQ5_LOXAF UBE2S UBE2S LMNB2 LMNB2 G3TI55_LOXAF G3TI55_LOXAF CDK3 CDK3 TNIK TNIK NBN NBN LMNB1 LMNB1 ANAPC1 ANAPC1 MAPKAPK5 MAPKAPK5 CDK6 CDK6 MAPKAPK2 MAPKAPK2 H1-1 H1-1 ERF ERF NPTXR NPTXR FAM89A FAM89A JUN JUN ENSLAFP00000016306 ENSLAFP00000016306 ENSLAFP00000016544 ENSLAFP00000016544 CDKN2B CDKN2B ANAPC16 ANAPC16 RING1 RING1 TLX3 TLX3 LOC100657920 LOC100657920 CBX7 CBX7 ID1 ID1 UBA52 UBA52 G3TR32_LOXAF G3TR32_LOXAF LOC111752373 LOC111752373 BARX1 BARX1 CBX2 CBX2 G3TS21_LOXAF G3TS21_LOXAF NME9 NME9 ENSLAFP00000018530 ENSLAFP00000018530 H2AZ1 H2AZ1 LOC100675676 LOC100675676 ENSLAFP00000018749 ENSLAFP00000018749 ENSLAFP00000019049 ENSLAFP00000019049 ENSLAFP00000019204 ENSLAFP00000019204 H4C11 H4C11 TXNDC2 TXNDC2 PHC2 PHC2 ENSLAFP00000019836 ENSLAFP00000019836 MRE11 MRE11 CDK2 CDK2 PHC1 PHC1 H2BC11 H2BC11 CEBPB CEBPB HMGA1 HMGA1 ASF1B ASF1B EED EED G3TZY9_LOXAF G3TZY9_LOXAF LOC100660148 LOC100660148 RPS27A RPS27A G3U0A6_LOXAF G3U0A6_LOXAF G3U0R3_LOXAF G3U0R3_LOXAF H2BC5 H2BC5 ANAPC11 ANAPC11 G3U1P0_LOXAF G3U1P0_LOXAF FZR1 FZR1 G3U1Z3_LOXAF G3U1Z3_LOXAF H1-2 H1-2 RNF2 RNF2 ENSLAFP00000022509 ENSLAFP00000022509 G3U3Z9_LOXAF G3U3Z9_LOXAF HMGA2 HMGA2 ENSLAFP00000022709 ENSLAFP00000022709 ENSLAFP00000022732 ENSLAFP00000022732 CDKN1A CDKN1A ENSLAFP00000022963 ENSLAFP00000022963 H2BC12 H2BC12 G3U6D1_LOXAF G3U6D1_LOXAF MAP2K3 MAP2K3 G3U6U6_LOXAF G3U6U6_LOXAF ENSLAFP00000023559 ENSLAFP00000023559 ETS1 ETS1 TXNDC8 TXNDC8 LOC100665018 LOC100665018 G3U8T3_LOXAF G3U8T3_LOXAF CDKN2D CDKN2D H1-4 H1-4 G3U933_LOXAF G3U933_LOXAF G3U9C8_LOXAF G3U9C8_LOXAF DUSP13 DUSP13 FOS FOS G3U9V5_LOXAF G3U9V5_LOXAF MAPK8 MAPK8 H3-4 H3-4 H2BC3 H2BC3 G3UAZ0_LOXAF G3UAZ0_LOXAF ENSLAFP00000025084 ENSLAFP00000025084 G3UB93_LOXAF G3UB93_LOXAF H2BC18 H2BC18 UBB UBB LOC100658484 LOC100658484 G3UD01_LOXAF G3UD01_LOXAF G3UDE4_LOXAF G3UDE4_LOXAF TERF2IP TERF2IP MAPKAPK3 MAPKAPK3 MAPK9 MAPK9 G3UFS4_LOXAF G3UFS4_LOXAF ENSLAFP00000026689 ENSLAFP00000026689
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
ENSLAFP00000027715annotation not available (136 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
ENSLAFP00000027918annotation not available (126 aa)
ENSLAFP00000027938annotation not available (103 aa)
ENSLAFP00000027955annotation not available (103 aa)
ENSLAFP00000028008annotation not available (126 aa)
ETV3LETS variant 3 like. (211 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
ENSLAFP00000028190annotation not available (104 aa)
G3UKU6_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
NPTX1Neuronal pentraxin 1. (285 aa)
PHC3Polyhomeotic homolog 3. (980 aa)
ENSLAFP00000028516annotation not available (136 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
UBCUncharacterized protein. (381 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
RPS6KA2Ribosomal protein S6 kinase. (737 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
G3UNK7_LOXAFHistone H2B; Belongs to the histone H2B family. (134 aa)
H1-6Histone cluster 1 H1 family member t. (207 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
HLXH2.0 like homeobox. (491 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
H1-0H1 histone family member 0. (194 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
NRKNik related kinase. (1285 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
LOC100655240Histone domain-containing protein. (136 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
UBN1Ubinuclein 1. (1138 aa)
CDC16Cell division cycle 16. (624 aa)
LOC100661012Histone H2B; Belongs to the histone H2B family. (126 aa)
TLX1T cell leukemia homeobox 1. (330 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
HIST1H2BAHistone cluster 1 H2B family member a; Belongs to the histone H2B family. (127 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
BARHL2BarH like homeobox 2. (382 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (834 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TERF2TERF2_RBM domain-containing protein. (142 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (703 aa)
DBX2Developing brain homeobox 2. (264 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
G3SVD7_LOXAFUncharacterized protein. (241 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111752376Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H1-5Histone cluster 1 H1 family member b. (225 aa)
LOC100662145Histone H2B; Belongs to the histone H2B family. (126 aa)
CDC23Cell division cycle 23. (597 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1254 aa)
POT1Protection of telomeres 1. (601 aa)
BARX2BARX homeobox 2. (279 aa)
NME8NME/NM23 family member 8. (591 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1279 aa)
ANAPC7Anaphase promoting complex subunit 7. (564 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (127 aa)
H1-3Histone cluster 1 H1 family member d. (221 aa)
ETV3ETS variant 3. (513 aa)
RPS6KA3Ribosomal protein S6 kinase. (737 aa)
LOC100669973Histone H2B; Belongs to the histone H2B family. (126 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (432 aa)
DBX1Developing brain homeobox 1. (344 aa)
CBX8Chromobox 8. (365 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
ANAPC5Anaphase promoting complex subunit 5. (743 aa)
LOC100672618Histone H3; Belongs to the histone H3 family. (136 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1225 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
CDC26Cell division cycle 26. (85 aa)
NPTX2Neuronal pentraxin 2. (432 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (361 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (801 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (226 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
CABIN1Calcineurin binding protein 1. (2182 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1014 aa)
LOC100675119Histone H2B; Belongs to the histone H2B family. (127 aa)
CDC27Cell division cycle 27. (831 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (846 aa)
SCML2Uncharacterized protein. (125 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
TM7SF3Transmembrane 7 superfamily member 3. (540 aa)
TXNThioredoxin. (98 aa)
SCMH1SAM domain-containing protein. (662 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (326 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (426 aa)
TINF2TERF1 interacting nuclear factor 2. (428 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
EP400E1A binding protein p400. (3005 aa)
MINK1Misshapen like kinase 1. (1341 aa)
BARHL1BarH like homeobox 1. (327 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (545 aa)
G5E6Z7_LOXAFHistone domain-containing protein. (129 aa)
SRCAPUncharacterized protein. (3042 aa)
G3THQ5_LOXAFRING-type domain-containing protein. (330 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (223 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (587 aa)
G3TI55_LOXAFSAM domain-containing protein. (330 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
TNIKTRAF2 and NCK interacting kinase. (1269 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (466 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAPKAPK2MAPK activated protein kinase 2. (308 aa)
H1-1Histone cluster 1 H1 family member a. (213 aa)
ERFETS2 repressor factor. (547 aa)
NPTXRChromo domain-containing protein. (680 aa)
FAM89AFamily with sequence similarity 89 member A. (176 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
ENSLAFP00000016306annotation not available (103 aa)
ENSLAFP00000016544annotation not available (136 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
ANAPC16Anaphase promoting complex subunit 16. (108 aa)
RING1Ring finger protein 1. (406 aa)
TLX3T cell leukemia homeobox 3. (291 aa)
LOC100657920Histone H2B; Belongs to the histone H2B family. (126 aa)
CBX7Chromobox 7. (248 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
G3TR32_LOXAFSAM domain-containing protein. (508 aa)
LOC111752373Histone H3; Belongs to the histone H3 family. (136 aa)
BARX1BARX homeobox 1. (180 aa)
CBX2Chromobox 2. (486 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
NME9NME/NM23 family member 9; Belongs to the NDK family. (301 aa)
ENSLAFP00000018530annotation not available (103 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC100675676Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
ENSLAFP00000018749annotation not available (136 aa)
ENSLAFP00000019049annotation not available (136 aa)
ENSLAFP00000019204annotation not available (127 aa)
H4C11H4 clustered histone 11. (103 aa)
TXNDC2Thioredoxin; Belongs to the thioredoxin family. (105 aa)
PHC2Polyhomeotic homolog 2. (948 aa)
ENSLAFP00000019836annotation not available (136 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PHC1Polyhomeotic homolog 1. (1013 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (135 aa)
CEBPBBZIP domain-containing protein. (124 aa)
HMGA1High mobility group AT-hook 1. (107 aa)
ASF1BAnti-silencing function 1B histone chaperone. (202 aa)
EEDEmbryonic ectoderm development. (510 aa)
G3TZY9_LOXAFH15 domain-containing protein. (218 aa)
LOC100660148Histone H2B; Belongs to the histone H2B family. (126 aa)
RPS27AUbiquitin-like domain-containing protein. (144 aa)
G3U0A6_LOXAFUncharacterized protein. (522 aa)
G3U0R3_LOXAFUBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
G3U1P0_LOXAFHomeobox domain-containing protein. (160 aa)
FZR1Fizzy and cell division cycle 20 related 1. (452 aa)
G3U1Z3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
H1-2Histone cluster 1 H1 family member c. (183 aa)
RNF2RING-type domain-containing protein. (308 aa)
ENSLAFP00000022509annotation not available (126 aa)
G3U3Z9_LOXAFUncharacterized protein. (134 aa)
HMGA2Uncharacterized protein. (108 aa)
ENSLAFP00000022709annotation not available (126 aa)
ENSLAFP00000022732annotation not available (103 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSLAFP00000022963annotation not available (103 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (135 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
ENSLAFP00000023559annotation not available (136 aa)
ETS1ETS proto-oncogene 1, transcription factor. (438 aa)
TXNDC8Thioredoxin domain containing 8. (119 aa)
LOC100665018Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
G3U8T3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
G3U933_LOXAFUBIQUITIN_CONJUGAT_2 domain-containing protein. (172 aa)
G3U9C8_LOXAFUbiquitin-like domain-containing protein. (172 aa)
DUSP13Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (316 aa)
G3U9V5_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
ENSLAFP00000025084annotation not available (136 aa)
G3UB93_LOXAFRAWUL domain-containing protein. (334 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
UBBUbiquitin B. (305 aa)
LOC100658484Histone H3; Belongs to the histone H3 family. (136 aa)
G3UD01_LOXAFUncharacterized protein. (743 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
TERF2IPTERF2 interacting protein. (396 aa)
MAPKAPK3MAPK activated protein kinase 3. (385 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
G3UFS4_LOXAFUncharacterized protein. (259 aa)
ENSLAFP00000026689annotation not available (136 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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