STRINGSTRING
HDAC1 HDAC1 CHD3 CHD3 SUDS3 SUDS3 SAP30L SAP30L RBBP4 RBBP4 GATAD2B GATAD2B SAP30 SAP30 PHF21A PHF21A MTA3 MTA3 RCOR1 RCOR1 HDAC2 HDAC2 CHD5 CHD5 KDM1A KDM1A AIRE AIRE ARID4A ARID4A GATAD2A GATAD2A WDR73 WDR73 RCOR3 RCOR3 BRMS1 BRMS1 RBBP7 RBBP7 BRMS1L BRMS1L HMG20A HMG20A GPS2 GPS2 CHD4 CHD4 HMG20B HMG20B PHF21B PHF21B RCOR2 RCOR2 ARID4B ARID4B REST REST WDR26 WDR26 MTA2 MTA2 SAP18 SAP18 NCOR1 NCOR1 MTA1 MTA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1876 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (329 aa)
SAP30LSAP30 like. (182 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
GATAD2BGATA zinc finger domain containing 2B. (593 aa)
SAP30Sin3A associated protein 30. (115 aa)
PHF21APHD finger protein 21A. (630 aa)
MTA3Metastasis associated 1 family member 3. (532 aa)
RCOR1REST corepressor 1. (369 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (487 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1928 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
AIREAutoimmune regulator. (557 aa)
ARID4AAT-rich interaction domain 4A. (1268 aa)
GATAD2AGATA zinc finger domain containing 2A. (628 aa)
WDR73WD repeat domain 73. (369 aa)
RCOR3REST corepressor 3. (478 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (248 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (426 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
HMG20AHigh mobility group 20A. (347 aa)
GPS2G protein pathway suppressor 2. (327 aa)
CHD4Uncharacterized protein. (1895 aa)
HMG20BHigh mobility group 20B. (316 aa)
PHF21BPHD finger protein 21B. (436 aa)
RCOR2REST corepressor 2. (524 aa)
ARID4BAT-rich interaction domain 4B. (1312 aa)
RESTRE1 silencing transcription factor. (1067 aa)
WDR26WD repeat domain 26. (640 aa)
MTA2Metastasis associated 1 family member 2. (667 aa)
SAP18Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or durin [...] (153 aa)
NCOR1Nuclear receptor corepressor 1. (2457 aa)
MTA1Metastasis associated 1. (660 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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