STRINGSTRING
PHC3 PHC3 PSMD6 PSMD6 CHD3 CHD3 RHEB RHEB PSMA8 PSMA8 EZH2 EZH2 PSMD2 PSMD2 PSMB3 PSMB3 RBBP4 RBBP4 GATAD2B GATAD2B RERE RERE CSNK2B CSNK2B PML PML PSMD13 PSMD13 AKT2 AKT2 CSNK2A1 CSNK2A1 PSMB8 PSMB8 PSMC5 PSMC5 PSMD11 PSMD11 PSMD5 PSMD5 SALL4 SALL4 MLST8 MLST8 PSMD8 PSMD8 PSMD14 PSMD14 TNKS TNKS MTA3 MTA3 HDAC1 HDAC1 PSMC1 PSMC1 G3SVD7_LOXAF G3SVD7_LOXAF HDAC2 HDAC2 FRK FRK LAMTOR1 LAMTOR1 PSMA1 PSMA1 CHD5 CHD5 CRYBB3 CRYBB3 CBX8 CBX8 USP7 USP7 OTUD3 OTUD3 NPTX2 NPTX2 AIRE AIRE PSMD9 PSMD9 PSMA3 PSMA3 PSMD3 PSMD3 PSMB7 PSMB7 SNAI2 SNAI2 GATAD2A GATAD2A RHEBL1 RHEBL1 EZH1 EZH1 PSMD1 PSMD1 PSMD12 PSMD12 GUF1 GUF1 OTUD4 OTUD4 PSMA2 PSMA2 MECOM MECOM MKRN2 MKRN2 SCML2 SCML2 CRYGN CRYGN PSMD10 PSMD10 TRIM7 TRIM7 TRIM27 TRIM27 PSMA4 PSMA4 PSMB6 PSMB6 LAMTOR5 LAMTOR5 ATN1 ATN1 SCMH1 SCMH1 WWP2 WWP2 PSMD7 PSMD7 PSMD4 PSMD4 CSNK2A2 CSNK2A2 RBBP7 RBBP7 RNF141 RNF141 PSMB4 PSMB4 PSMC2 PSMC2 PSMC6 PSMC6 G3TE60_LOXAF G3TE60_LOXAF PSMB5 PSMB5 MTOR MTOR LAMTOR3 LAMTOR3 G3THQ5_LOXAF G3THQ5_LOXAF AKT3 AKT3 G3TI55_LOXAF G3TI55_LOXAF PSMA5 PSMA5 PSMA6 PSMA6 SLC38A9 SLC38A9 PSMC4 PSMC4 MKRN1 MKRN1 PSMB11 PSMB11 RRAGA RRAGA NPTXR NPTXR TXNDC11 TXNDC11 RING1 RING1 PSMF1 PSMF1 CBX7 CBX7 CHD4 CHD4 UBA52 UBA52 G3TR32_LOXAF G3TR32_LOXAF PSMB9 PSMB9 CBX2 CBX2 G3TSB1_LOXAF G3TSB1_LOXAF G3TTE2_LOXAF G3TTE2_LOXAF PHC2 PHC2 PSME4 PSME4 G3TWY9_LOXAF G3TWY9_LOXAF PSME3 PSME3 PHC1 PHC1 NEDD4 NEDD4 G3TZA6_LOXAF G3TZA6_LOXAF EED EED RPS27A RPS27A XIAP XIAP MAF1 MAF1 RNF2 RNF2 LAMTOR2 LAMTOR2 EGR1 EGR1 RRAGB RRAGB G3U777_LOXAF G3U777_LOXAF SALL2 SALL2 PSMA7 PSMA7 G3U9C8_LOXAF G3U9C8_LOXAF AKT1 AKT1 MKRN3 MKRN3 G3UB93_LOXAF G3UB93_LOXAF UBB UBB PSME1 PSME1 G3UD01_LOXAF G3UD01_LOXAF USP13 USP13 RRAGC RRAGC G3UFB2_LOXAF G3UFB2_LOXAF LY6G5B LY6G5B PSMB10 PSMB10 STUB1 STUB1 G3UGJ0_LOXAF G3UGJ0_LOXAF MTA2 MTA2 PSMB2 PSMB2 G3UHV4_LOXAF G3UHV4_LOXAF RNF146 RNF146 TNKS2 TNKS2 NPTX1 NPTX1 PSMB1 PSMB1 UBC UBC SNAI1 SNAI1 RRAGD RRAGD PSME2 PSME2 PSMC3 PSMC3 MTA1 MTA1 SUZ12 SUZ12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHC3Polyhomeotic homolog 3. (980 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1876 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PSMA8Proteasome subunit alpha type. (249 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (907 aa)
PSMB3Proteasome subunit beta. (205 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
GATAD2BGATA zinc finger domain containing 2B. (593 aa)
REREArginine-glutamic acid dipeptide repeats. (1558 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
PMLPromyelocytic leukemia. (861 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (378 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (305 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
TNKSPoly [ADP-ribose] polymerase. (1317 aa)
MTA3Metastasis associated 1 family member 3. (532 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
G3SVD7_LOXAFUncharacterized protein. (241 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (487 aa)
FRKTyrosine-protein kinase. (516 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1928 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
CBX8Chromobox 8. (365 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1078 aa)
OTUD3OTU deubiquitinase 3. (396 aa)
NPTX2Neuronal pentraxin 2. (432 aa)
AIREAutoimmune regulator. (557 aa)
PSMD9PDZ domain-containing protein. (225 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (533 aa)
PSMB7Proteasome subunit beta. (277 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
GATAD2AGATA zinc finger domain containing 2A. (628 aa)
RHEBL1RHEB like 1. (183 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (948 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (670 aa)
OTUD4OTU deubiquitinase 4. (1000 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
MECOMMDS1 and EVI1 complex locus. (1042 aa)
MKRN2Makorin ring finger protein 2. (414 aa)
SCML2Uncharacterized protein. (125 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
TRIM7Tripartite motif containing 7. (305 aa)
TRIM27Tripartite motif containing 27. (615 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMB6Proteasome subunit beta. (208 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
ATN1Atrophin 1. (1177 aa)
SCMH1SAM domain-containing protein. (662 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (349 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (426 aa)
RNF141Ring finger protein 141. (230 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
G3TE60_LOXAFRaptor_N domain-containing protein. (974 aa)
PSMB5Proteasome subunit beta. (263 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (121 aa)
G3THQ5_LOXAFRING-type domain-containing protein. (330 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G3TI55_LOXAFSAM domain-containing protein. (330 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
SLC38A9Solute carrier family 38 member 9. (562 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
MKRN1Makorin ring finger protein 1. (482 aa)
PSMB11Proteasome subunit beta. (253 aa)
RRAGARas related GTP binding A. (313 aa)
NPTXRChromo domain-containing protein. (680 aa)
TXNDC11Thioredoxin domain containing 11. (891 aa)
RING1Ring finger protein 1. (406 aa)
PSMF1Proteasome inhibitor subunit 1. (270 aa)
CBX7Chromobox 7. (248 aa)
CHD4Uncharacterized protein. (1895 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
G3TR32_LOXAFSAM domain-containing protein. (508 aa)
PSMB9Proteasome subunit beta. (219 aa)
CBX2Chromobox 2. (486 aa)
G3TSB1_LOXAFUncharacterized protein. (195 aa)
G3TTE2_LOXAFUncharacterized protein. (233 aa)
PHC2Polyhomeotic homolog 2. (948 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
G3TWY9_LOXAFANK_REP_REGION domain-containing protein. (225 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PHC1Polyhomeotic homolog 1. (1013 aa)
NEDD4E3 ubiquitin-protein ligase. (845 aa)
G3TZA6_LOXAFUncharacterized protein. (202 aa)
EEDEmbryonic ectoderm development. (510 aa)
RPS27AUbiquitin-like domain-containing protein. (144 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
MAF1Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (257 aa)
RNF2RING-type domain-containing protein. (308 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (548 aa)
RRAGBRas related GTP binding B. (376 aa)
G3U777_LOXAFUncharacterized protein. (373 aa)
SALL2Spalt like transcription factor 2. (1004 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
G3U9C8_LOXAFUbiquitin-like domain-containing protein. (172 aa)
AKT1Non-specific serine/threonine protein kinase. (459 aa)
MKRN3Makorin ring finger protein 3. (455 aa)
G3UB93_LOXAFRAWUL domain-containing protein. (334 aa)
UBBUbiquitin B. (305 aa)
PSME1Proteasome activator subunit 1. (249 aa)
G3UD01_LOXAFUncharacterized protein. (743 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (866 aa)
RRAGCRas related GTP binding C. (403 aa)
G3UFB2_LOXAFPA28_beta domain-containing protein. (141 aa)
LY6G5BUncharacterized protein. (194 aa)
PSMB10Proteasome subunit beta 10. (275 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
G3UGJ0_LOXAFTankyrase_bdg_C domain-containing protein. (315 aa)
MTA2Metastasis associated 1 family member 2. (667 aa)
PSMB2Proteasome subunit beta. (203 aa)
G3UHV4_LOXAFUncharacterized protein. (169 aa)
RNF146Ring finger protein 146. (361 aa)
TNKS2Poly [ADP-ribose] polymerase. (1247 aa)
NPTX1Neuronal pentraxin 1. (285 aa)
PSMB1Proteasome subunit beta. (209 aa)
UBCUncharacterized protein. (381 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
RRAGDRas related GTP binding D. (450 aa)
PSME2Uncharacterized protein. (250 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (450 aa)
MTA1Metastasis associated 1. (660 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (26%) [HD]