(75 nodes) Signaling by Insulin receptor network (Loxodonta africana)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	MAPK3	Mitogen-activated protein kinase. (327 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	NRDC	Nardilysin convertase. (1222 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	GAB1	GRB2 associated binding protein 1. (694 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ATP6V1E1	ATPase H+ transporting V1 subunit E1. (229 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (988 aa)
	ATP6V0E2	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	TRIB3	Tribbles pseudokinase 3. (358 aa)
	LIM2	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (214 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (464 aa)
	ATP6V0D2	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	ATP6V0D1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1359 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	MAPK1	Mitogen-activated protein kinase. (329 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (383 aa)
	ATP6AP1L	ATPase H+ transporting accessory protein 1 like. (198 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (247 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (617 aa)
	ATP6V1E2	ATPase H+ transporting V1 subunit E2. (226 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	FGFR4	Fibroblast growth factor receptor. (801 aa)
	GRB10	Growth factor receptor bound protein 10. (430 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (996 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	CNST	Consortin, connexin sorting protein. (719 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (841 aa)
	FGFR1	Fibroblast growth factor receptor. (831 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	ATP6V1G2	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (117 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	NPM3	Nucleophosmin/nucleoplasmin 3. (176 aa)
	ATP6V1B1	ATPase H+ transporting V1 subunit B1. (508 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	G3TWY0_LOXAF	Uncharacterized protein. (88 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (890 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (510 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
	PDE3B	Phosphodiesterase. (1112 aa)
	SPEM2	SPEM family member 2. (471 aa)
	FLT3LG	Fms related tyrosine kinase 3 ligand. (240 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	INSR	Tyrosine-protein kinase receptor. (1366 aa)
	SPEM1	Spermatid maturation 1. (307 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (414 aa)
	TLR9	TIR domain-containing protein. (1030 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (134 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (813 aa)
	G3UL95_LOXAF	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	FGF18	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (198 aa)
	FGFR2	Fibroblast growth factor receptor. (840 aa)
	GAB2	GRB2 associated binding protein 2. (672 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6V0A1	ENSLAFP00000007355	ENSLAFP00000008900	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.998
ATP6AP1	ATP6V0A2	ENSLAFP00000007355	ENSLAFP00000006145	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.983
ATP6AP1	ATP6V0A4	ENSLAFP00000007355	ENSLAFP00000014965	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.990
ATP6AP1	ATP6V0B	ENSLAFP00000007355	ENSLAFP00000014383	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.999
ATP6AP1	ATP6V0C	ENSLAFP00000007355	ENSLAFP00000013379	ATPase H+ transporting accessory protein 1.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.998
ATP6AP1	ATP6V0D1	ENSLAFP00000007355	ENSLAFP00000007515	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.995
ATP6AP1	ATP6V0D2	ENSLAFP00000007355	ENSLAFP00000007360	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.995
ATP6AP1	ATP6V0E2	ENSLAFP00000007355	ENSLAFP00000005714	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.980
ATP6AP1	ATP6V1A	ENSLAFP00000007355	ENSLAFP00000011269	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit A.	0.961
ATP6AP1	ATP6V1B1	ENSLAFP00000007355	ENSLAFP00000017967	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit B1.	0.960
ATP6AP1	ATP6V1B2	ENSLAFP00000007355	ENSLAFP00000020420	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.960
ATP6AP1	ATP6V1C1	ENSLAFP00000007355	ENSLAFP00000009952	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.957
ATP6AP1	ATP6V1C2	ENSLAFP00000007355	ENSLAFP00000021592	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.948
ATP6AP1	ATP6V1D	ENSLAFP00000007355	ENSLAFP00000011225	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit D.	0.995
ATP6AP1	ATP6V1E1	ENSLAFP00000007355	ENSLAFP00000003174	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit E1.	0.949
ATP6AP1	ATP6V1E2	ENSLAFP00000007355	ENSLAFP00000011472	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit E2.	0.949
ATP6AP1	ATP6V1F	ENSLAFP00000007355	ENSLAFP00000007328	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.949
ATP6AP1	ATP6V1G1	ENSLAFP00000007355	ENSLAFP00000011244	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.867
ATP6AP1	ATP6V1G2	ENSLAFP00000007355	ENSLAFP00000015819	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.937
ATP6AP1	ATP6V1G3	ENSLAFP00000007355	ENSLAFP00000017269	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.864

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