STRINGSTRING
GTF2F1 GTF2F1 NCOA3 NCOA3 GTF2A1 GTF2A1 MED1 MED1 TRPS1 TRPS1 POLR2D POLR2D G3SPD3_LOXAF G3SPD3_LOXAF LOC100655240 LOC100655240 GATA3 GATA3 POLR2B POLR2B GREB1 GREB1 POLR2H POLR2H PRMT8 PRMT8 LOC100661012 LOC100661012 POLR2G POLR2G CARM1 CARM1 HIST1H2BA HIST1H2BA DDX5 DDX5 POLR2K POLR2K LOC111752376 LOC111752376 LOC100662145 LOC100662145 G3SWC6_LOXAF G3SWC6_LOXAF TBP TBP H2AZ2 H2AZ2 PGR PGR LOC100669973 LOC100669973 EBAG9 EBAG9 KANK4 KANK4 G3UNK7_LOXAF G3UNK7_LOXAF KDM1A KDM1A LOC100672618 LOC100672618 PTGES3 PTGES3 FOSB FOSB NCOA2 NCOA2 GTF2F2 GTF2F2 KANK1 KANK1 GTF2A2 GTF2A2 LOC100675119 LOC100675119 USF1 USF1 CXXC5 CXXC5 EP300 EP300 POLR2F POLR2F TFF3 TFF3 TBPL1 TBPL1 KANK3 KANK3 NCOA1 NCOA1 ZC3H12B ZC3H12B ESR1 ESR1 POLR2I POLR2I CREBBP CREBBP KAT5 KAT5 G5E6Z7_LOXAF G5E6Z7_LOXAF CDK9 CDK9 TBPL2 TBPL2 CITED1 CITED1 ZNF217 ZNF217 SP1 SP1 PRMT1 PRMT1 MYB MYB ZC3H12A ZC3H12A ENSLAFP00000016306 ENSLAFP00000016306 POLR2J POLR2J ZC3H12D ZC3H12D ENSLAFP00000016544 ENSLAFP00000016544 KANK2 KANK2 CHD1 CHD1 LOC100657920 LOC100657920 LOC111752373 LOC111752373 ENSLAFP00000018530 ENSLAFP00000018530 H2AZ1 H2AZ1 KDM4B KDM4B LOC100675676 LOC100675676 ENSLAFP00000018749 ENSLAFP00000018749 ENSLAFP00000019049 ENSLAFP00000019049 FKBP4 FKBP4 ENSLAFP00000019204 ENSLAFP00000019204 H4C11 H4C11 POLR2A POLR2A HSP90AB1 HSP90AB1 ENSLAFP00000019836 ENSLAFP00000019836 H2BC11 H2BC11 LOC100660148 LOC100660148 H2BC5 H2BC5 GTF2A1L GTF2A1L G3U1Z3_LOXAF G3U1Z3_LOXAF ENSLAFP00000022509 ENSLAFP00000022509 ENSLAFP00000022709 ENSLAFP00000022709 ENSLAFP00000022732 ENSLAFP00000022732 USF2 USF2 ENSLAFP00000022963 ENSLAFP00000022963 H2BC12 H2BC12 CCNT1 CCNT1 ENSLAFP00000023559 ENSLAFP00000023559 LOC100665018 LOC100665018 ZC3H12C ZC3H12C POLR2E POLR2E G3U8T3_LOXAF G3U8T3_LOXAF G3U9V5_LOXAF G3U9V5_LOXAF H3-4 H3-4 H2BC3 H2BC3 ENSLAFP00000025084 ENSLAFP00000025084 UPK3BL2 UPK3BL2 H2BC18 H2BC18 LOC100658484 LOC100658484 HSP90AA1 HSP90AA1 GREB1L GREB1L FOXA1 FOXA1 NRIP1 NRIP1 ENSLAFP00000026689 ENSLAFP00000026689 ENSLAFP00000027715 ENSLAFP00000027715 ENSLAFP00000027918 ENSLAFP00000027918 ENSLAFP00000027938 ENSLAFP00000027938 G3UJE3_LOXAF G3UJE3_LOXAF ENSLAFP00000027955 ENSLAFP00000027955 ENSLAFP00000028008 ENSLAFP00000028008 ENSLAFP00000028190 ENSLAFP00000028190 G3UKU6_LOXAF G3UKU6_LOXAF ENSLAFP00000028516 ENSLAFP00000028516 H2BC21 H2BC21 POLR2C POLR2C G3ULS6_LOXAF G3ULS6_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (400 aa)
NCOA3Nuclear receptor coactivator. (1413 aa)
GTF2A1General transcription factor IIA subunit 1. (367 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
TRPS1Transcriptional repressor GATA binding 1. (1294 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
G3SPD3_LOXAFTranscription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (504 aa)
LOC100655240Histone domain-containing protein. (136 aa)
GATA3GATA binding protein 3. (443 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (929 aa)
GREB1Uncharacterized protein. (1941 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
LOC100661012Histone H2B; Belongs to the histone H2B family. (126 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (576 aa)
HIST1H2BAHistone cluster 1 H2B family member a; Belongs to the histone H2B family. (127 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (648 aa)
POLR2KUncharacterized protein. (57 aa)
LOC111752376Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC100662145Histone H2B; Belongs to the histone H2B family. (126 aa)
G3SWC6_LOXAFUncharacterized protein. (93 aa)
TBPTATA-box binding protein. (314 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (127 aa)
PGRNR LBD domain-containing protein. (291 aa)
LOC100669973Histone H2B; Belongs to the histone H2B family. (126 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
KANK4KN motif and ankyrin repeat domains 4. (1013 aa)
G3UNK7_LOXAFHistone H2B; Belongs to the histone H2B family. (134 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
LOC100672618Histone H3; Belongs to the histone H3 family. (136 aa)
PTGES3CS domain-containing protein. (159 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
NCOA2Nuclear receptor coactivator. (1461 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
KANK1Uncharacterized protein. (907 aa)
GTF2A2General transcription factor IIA subunit 2. (141 aa)
LOC100675119Histone H2B; Belongs to the histone H2B family. (127 aa)
USF1Upstream transcription factor 1. (310 aa)
CXXC5CXXC finger protein 5. (319 aa)
EP300E1A binding protein p300. (2420 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
TFF3Trefoil factor 3. (81 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
KANK3ANK_REP_REGION domain-containing protein. (356 aa)
NCOA1Nuclear receptor coactivator. (1444 aa)
ZC3H12BZinc finger CCCH-type containing 12B. (837 aa)
ESR1NR LBD domain-containing protein. (232 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
CREBBPCREB binding protein. (2433 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (545 aa)
G5E6Z7_LOXAFHistone domain-containing protein. (129 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
TBPL2TATA-box binding protein like 2. (351 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (173 aa)
ZNF217Zinc finger protein 217. (1062 aa)
SP1Sp1 transcription factor. (784 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
MYBMYB proto-oncogene, transcription factor. (723 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSLAFP00000016306annotation not available (103 aa)
POLR2JRNA polymerase II subunit J. (117 aa)
ZC3H12DC3H1-type domain-containing protein. (320 aa)
ENSLAFP00000016544annotation not available (136 aa)
KANK2KN motif and ankyrin repeat domains 2. (844 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1692 aa)
LOC100657920Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111752373Histone H3; Belongs to the histone H3 family. (136 aa)
ENSLAFP00000018530annotation not available (103 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
KDM4BLysine demethylase 4B. (1123 aa)
LOC100675676Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
ENSLAFP00000018749annotation not available (136 aa)
ENSLAFP00000019049annotation not available (136 aa)
FKBP4Peptidylprolyl isomerase. (420 aa)
ENSLAFP00000019204annotation not available (127 aa)
H4C11H4 clustered histone 11. (103 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
ENSLAFP00000019836annotation not available (136 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (135 aa)
LOC100660148Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2A1LGeneral transcription factor IIA subunit 1 like. (477 aa)
G3U1Z3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
ENSLAFP00000022509annotation not available (126 aa)
ENSLAFP00000022709annotation not available (126 aa)
ENSLAFP00000022732annotation not available (103 aa)
USF2Upstream transcription factor 2, c-fos interacting. (270 aa)
ENSLAFP00000022963annotation not available (103 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (135 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (732 aa)
ENSLAFP00000023559annotation not available (136 aa)
LOC100665018Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (627 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
G3U8T3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
G3U9V5_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSLAFP00000025084annotation not available (136 aa)
UPK3BL2Uncharacterized protein. (253 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100658484Histone H3; Belongs to the histone H3 family. (136 aa)
HSP90AA1HATPase_c domain-containing protein. (736 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1634 aa)
FOXA1Forkhead box A1. (469 aa)
NRIP1Nuclear receptor interacting protein 1. (1159 aa)
ENSLAFP00000026689annotation not available (136 aa)
ENSLAFP00000027715annotation not available (136 aa)
ENSLAFP00000027918annotation not available (126 aa)
ENSLAFP00000027938annotation not available (103 aa)
G3UJE3_LOXAFANK_REP_REGION domain-containing protein. (352 aa)
ENSLAFP00000027955annotation not available (103 aa)
ENSLAFP00000028008annotation not available (126 aa)
ENSLAFP00000028190annotation not available (104 aa)
G3UKU6_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
ENSLAFP00000028516annotation not available (136 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
G3ULS6_LOXAFUncharacterized protein. (491 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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