STRINGSTRING
PARP1 PARP1 ATM ATM RGS13 RGS13 CLOCK CLOCK RGS6 RGS6 DDB1 DDB1 HIF1A HIF1A BRCA1 BRCA1 PRKACB PRKACB CXCR4 CXCR4 MDM2 MDM2 APTX APTX GRK7 GRK7 PRMT5 PRMT5 GRK1 GRK1 RAD51C RAD51C RHO RHO GIT2 GIT2 FANCA FANCA BCHE BCHE ABCB1 ABCB1 FBXO44 FBXO44 NFE2L2 NFE2L2 RAD52 RAD52 NOX4 NOX4 RXFP3 RXFP3 RGSL1 RGSL1 ARRB1 ARRB1 PARP2 PARP2 PRKACA PRKACA CUL4B CUL4B ADRB2 ADRB2 POMC POMC CXCL12 CXCL12 CAV3 CAV3 LIG4 LIG4 HMOX1 HMOX1 RGS2 RGS2 INSR INSR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (974 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
RGS13Regulator of G protein signaling 13. (158 aa)
CLOCKClock circadian regulator. (849 aa)
RGS6Regulator of G protein signaling 6. (414 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (836 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1854 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)
APTXAprataxin. (344 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (594 aa)
RAD51CRAD51 paralog C. (368 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
GIT2GIT ArfGAP 2. (760 aa)
FANCAFA complementation group A. (1436 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
ABCB1ATP binding cassette subfamily B member 1. (1240 aa)
FBXO44Uncharacterized protein. (255 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
RAD52RAD52 homolog, DNA repair protein. (411 aa)
NOX4NADPH oxidase 4. (579 aa)
RXFP3G_PROTEIN_RECEP_F1_2 domain-containing protein. (445 aa)
RGSL1RGS domain-containing protein. (409 aa)
ARRB1Arrestin beta 1. (418 aa)
PARP2Poly [ADP-ribose] polymerase. (569 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CUL4BCullin 4B; Belongs to the cullin family. (946 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (247 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
LIG4DNA ligase. (913 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
RGS2Regulator of G protein signaling 2. (212 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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