STRINGSTRING
TGFB2 TGFB2 IL2 IL2 IFNG IFNG IL21 IL21 TGFB1 TGFB1 IL15 IL15 G3TBD7_LOXAF G3TBD7_LOXAF BCR BCR G3THD9_LOXAF G3THD9_LOXAF IL10 IL10 CD27 CD27 TGFB3 TGFB3 G3TW84_LOXAF G3TW84_LOXAF LOC104847000 LOC104847000 IL18 IL18 G3UJ54_LOXAF G3UJ54_LOXAF CD4 CD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (150 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
G3TBD7_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
BCRBCR activator of RhoGEF and GTPase. (1250 aa)
G3THD9_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (245 aa)
IL10Interleukin 10. (178 aa)
CD27CD27 molecule. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
G3TW84_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
LOC104847000Peptidase S1 domain-containing protein. (225 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (195 aa)
G3UJ54_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
CD4CD4 molecule. (471 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.