STRINGSTRING
PTEN PTEN TGFB2 TGFB2 THBS1 THBS1 RAD21 RAD21 DLX2 DLX2 MMUT MMUT MYO10 MYO10 CYP19A1 CYP19A1 G3ULJ2_LOXAF G3ULJ2_LOXAF FAH FAH G3UEN1_LOXAF G3UEN1_LOXAF NRP2 NRP2 CDKN1A CDKN1A ZEB1 ZEB1 MRE11 MRE11 TGFB3 TGFB3 G3TPT5_LOXAF G3TPT5_LOXAF PDGFRB PDGFRB AGRP AGRP MTOR MTOR AEN AEN DHRS3 DHRS3 APAF1 APAF1 EGFR EGFR LIF LIF SENP1 SENP1 PLTP PLTP ZEB2 ZEB2 LPIN1 LPIN1 TGFB1 TGFB1 MDM2 MDM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
THBS1Thrombospondin 1. (1169 aa)
RAD21RAD21 cohesin complex component. (635 aa)
DLX2Distal-less homeobox 2. (333 aa)
MMUTMethylmalonyl-CoA mutase. (750 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2058 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
G3ULJ2_LOXAFUncharacterized protein. (202 aa)
FAHFumarylacetoacetase. (395 aa)
G3UEN1_LOXAFUncharacterized protein. (201 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ZEB1Zinc finger E-box binding homeobox 1. (974 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
G3TPT5_LOXAFUncharacterized protein. (201 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
AGRPAgouti related neuropeptide. (133 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
AENApoptosis enhancing nuclease. (305 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
LIFUncharacterized protein. (201 aa)
SENP1SUMO specific peptidase 1. (666 aa)
PLTPPhospholipid transfer protein. (493 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1214 aa)
LPIN1Lipin 1. (929 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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