(22 nodes) (2020) Regulation of gene expression by growth hormone. network (Loxodonta africana)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Your Input:
	IRS1	Insulin receptor substrate 1. (1119 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	JAK1	Tyrosine-protein kinase. (1158 aa)
	STAT1	Signal transducer and activator of transcription. (756 aa)
	CISH	Cytokine inducible SH2 containing protein. (258 aa)
	LOC111752373	Histone H3; Belongs to the histone H3 family. (136 aa)
	IRS2	Insulin receptor substrate 2. (1342 aa)
	POU1F1	POU domain protein. (335 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (296 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	IGF2	Insulin like growth factor 2. (175 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	SRF	Serum response factor. (391 aa)
	LOC100655240	Histone domain-containing protein. (136 aa)
	TYK2	Tyrosine-protein kinase. (1169 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	LOC100672618	Histone H3; Belongs to the histone H3 family. (136 aa)
	STAT3	Signal transducer and activator of transcription. (772 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	LOC100658484	Histone H3; Belongs to the histone H3 family. (136 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	IFNG	ENSLAFP00000018546	ENSLAFP00000003740	Cytokine inducible SH2 containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.501
CISH	JAK1	ENSLAFP00000018546	ENSLAFP00000021176	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.407
CISH	JAK2	ENSLAFP00000018546	ENSLAFP00000006285	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.408
CISH	SOCS2	ENSLAFP00000018546	ENSLAFP00000028095	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 2.	0.450
CISH	STAT1	ENSLAFP00000018546	ENSLAFP00000020919	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.931
CISH	STAT3	ENSLAFP00000018546	ENSLAFP00000025834	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.942
CISH	STAT5A	ENSLAFP00000018546	ENSLAFP00000011770	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.929
CISH	STAT5B	ENSLAFP00000018546	ENSLAFP00000011764	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.943
CISH	TYK2	ENSLAFP00000018546	ENSLAFP00000003280	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.407
IFNG	CISH	ENSLAFP00000003740	ENSLAFP00000018546	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Cytokine inducible SH2 containing protein.	0.501
IFNG	JAK1	ENSLAFP00000003740	ENSLAFP00000021176	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.972
IFNG	JAK2	ENSLAFP00000003740	ENSLAFP00000006285	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.982
IFNG	STAT1	ENSLAFP00000003740	ENSLAFP00000020919	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.851
IFNG	STAT3	ENSLAFP00000003740	ENSLAFP00000025834	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.774
IFNG	STAT5A	ENSLAFP00000003740	ENSLAFP00000011770	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.470
IFNG	STAT5B	ENSLAFP00000003740	ENSLAFP00000011764	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.470
IFNG	TYK2	ENSLAFP00000003740	ENSLAFP00000003280	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.690
IGF2	IGFBP3	ENSLAFP00000009448	ENSLAFP00000011829	Insulin like growth factor 2.	Insulin like growth factor binding protein 3.	0.910
IGF2	IRS1	ENSLAFP00000009448	ENSLAFP00000025172	Insulin like growth factor 2.	Insulin receptor substrate 1.	0.414
IGF2	IRS2	ENSLAFP00000009448	ENSLAFP00000014424	Insulin like growth factor 2.	Insulin receptor substrate 2.	0.414

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