STRINGSTRING
JARID2 JARID2 SUZ12 SUZ12 NCOR1 NCOR1 G3UKU6_LOXAF G3UKU6_LOXAF INSR INSR TMPRSS2 TMPRSS2 LOC100658484 LOC100658484 H3-4 H3-4 G3U9V5_LOXAF G3U9V5_LOXAF G3U8T3_LOXAF G3U8T3_LOXAF G3U1Z3_LOXAF G3U1Z3_LOXAF AR AR LOC111752373 LOC111752373 SOX2 SOX2 AEBP2 AEBP2 MERTK MERTK EGFR EGFR IRF8 IRF8 LOC100672618 LOC100672618 HDAC3 HDAC3 TP53 TP53 LOC111752376 LOC111752376 LOC100655240 LOC100655240 EZH2 EZH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JARID2Jumonji and AT-rich interaction domain containing 2. (1236 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
NCOR1Nuclear receptor corepressor 1. (2457 aa)
G3UKU6_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (490 aa)
LOC100658484Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
G3U9V5_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
G3U8T3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
G3U1Z3_LOXAFHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
ARAndrogen receptor. (897 aa)
LOC111752373Histone H3; Belongs to the histone H3 family. (136 aa)
SOX2SRY-box transcription factor 2. (318 aa)
AEBP2AE binding protein 2. (494 aa)
MERTKMER proto-oncogene, tyrosine kinase. (976 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
IRF8Interferon regulatory factor 8. (426 aa)
LOC100672618Histone H3; Belongs to the histone H3 family. (136 aa)
HDAC3Hist_deacetyl domain-containing protein. (349 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
LOC111752376Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC100655240Histone domain-containing protein. (136 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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