STRINGSTRING
MSH6 MSH6 PLD1 PLD1 PRDM16 PRDM16 HPGD HPGD EZH2 EZH2 SASS6 SASS6 LOC100655240 LOC100655240 DNMT1 DNMT1 AKT2 AKT2 POLR2B POLR2B PLK2 PLK2 TDG TDG GSTA4 GSTA4 NR3C1 NR3C1 AK2 AK2 PLK1 PLK1 STAT6 STAT6 TET1 TET1 PGR PGR KCNB1 KCNB1 TP53 TP53 LOC100672618 LOC100672618 NFKB1 NFKB1 CLOCK CLOCK CENPS-CORT CENPS-CORT PER2 PER2 APLF APLF STAT4 STAT4 NANOG NANOG HIF1A HIF1A STAT5B STAT5B STAT5A STAT5A EGFR EGFR STAT2 STAT2 RARA RARA FANCI FANCI MSH2 MSH2 SUV39H2 SUV39H2 PHAX PHAX UQCRFS1 UQCRFS1 CHEK1 CHEK1 LOC111752373 LOC111752373 GTF2B GTF2B CRY1 CRY1 RXRA RXRA STAT1 STAT1 EED EED KLF4 KLF4 PLD2 PLD2 CXCL12 CXCL12 CD40 CD40 KDM2B KDM2B SIRT6 SIRT6 NPAS2 NPAS2 H3-4 H3-4 IRS1 IRS1 LOC100658484 LOC100658484 STAT3 STAT3 RELA RELA CRY2 CRY2 KCNA7 KCNA7 SUZ12 SUZ12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa)
PLD1Phospholipase. (1075 aa)
PRDM16PR/SET domain 16. (1270 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
LOC100655240Histone domain-containing protein. (136 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (929 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
TDGThymine DNA glycosylase. (411 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (776 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
STAT6Signal transducer and activator of transcription. (849 aa)
TET1Tet methylcytosine dioxygenase 1. (2139 aa)
PGRNR LBD domain-containing protein. (291 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
LOC100672618Histone H3; Belongs to the histone H3 family. (136 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
CLOCKClock circadian regulator. (849 aa)
CENPS-CORTCENPS-CORT readthrough. (162 aa)
PER2Period circadian regulator 2. (1252 aa)
APLFAprataxin and PNKP like factor. (465 aa)
STAT4Signal transducer and activator of transcription. (745 aa)
NANOGHomeobox domain-containing protein. (300 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (836 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
STAT2Signal transducer and activator of transcription. (841 aa)
RARARetinoic acid receptor alpha. (464 aa)
FANCIFA complementation group I. (1285 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (871 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (403 aa)
PHAXPhosphorylated adaptor for RNA export. (393 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
LOC111752373Histone H3; Belongs to the histone H3 family. (136 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
CRY1Cryptochrome circadian regulator 1. (606 aa)
RXRARetinoid X receptor alpha. (455 aa)
STAT1Signal transducer and activator of transcription. (756 aa)
EEDEmbryonic ectoderm development. (510 aa)
KLF4Kruppel like factor 4. (517 aa)
PLD2Phospholipase. (943 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CD40CD40 molecule. (260 aa)
KDM2BLysine demethylase 2B. (1305 aa)
SIRT6Sirtuin 6. (336 aa)
NPAS2Neuronal PAS domain protein 2. (810 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
IRS1Insulin receptor substrate 1. (1119 aa)
LOC100658484Histone H3; Belongs to the histone H3 family. (136 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
CRY2Cryptochrome circadian regulator 2. (592 aa)
KCNA7Ion_trans domain-containing protein; Belongs to the potassium channel family. (123 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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