(34 nodes) Pyruvate metabolism network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Your Input:
	LDHB	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)
	ME2	Malic enzyme. (584 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2344 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	LDHAL6B	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
	ME1	Malic enzyme. (572 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	FH	Fumarate hydratase. (508 aa)
	ME3	Malic enzyme. (604 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	G3T180_LOXAF	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (336 aa)
	PDHA2	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (392 aa)
	ALDH9A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (488 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (624 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	LOC100668729	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (609 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2332 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (663 aa)
	ALDH16A1	Aldedh domain-containing protein. (187 aa)
	MDH1	Malate dehydrogenase. (334 aa)
	ACYP1	Acylphosphatase. (156 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	ACYP2	Acylphosphatase. (82 aa)
	ALDH2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (515 aa)
	HAGH	Hydroxyacylglutathione hydrolase. (304 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSLAFP00000002195	ENSLAFP00000011316	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.901
ACACA	ACAT1	ENSLAFP00000002195	ENSLAFP00000027152	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.947
ACACA	ACAT2	ENSLAFP00000002195	ENSLAFP00000006633	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.948
ACACA	ACSS1	ENSLAFP00000002195	ENSLAFP00000009604	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase.	0.933
ACACA	ACSS2	ENSLAFP00000002195	ENSLAFP00000017841	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase short chain family member 2.	0.933
ACACA	DLAT	ENSLAFP00000002195	ENSLAFP00000008109	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.924
ACACA	ME1	ENSLAFP00000002195	ENSLAFP00000004303	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.414
ACACA	ME2	ENSLAFP00000002195	ENSLAFP00000001282	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.414
ACACA	ME3	ENSLAFP00000002195	ENSLAFP00000005762	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.414
ACACB	ACACA	ENSLAFP00000011316	ENSLAFP00000002195	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.901
ACACB	ACAT1	ENSLAFP00000011316	ENSLAFP00000027152	Acetyl-CoA carboxylase beta.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.947
ACACB	ACAT2	ENSLAFP00000011316	ENSLAFP00000006633	Acetyl-CoA carboxylase beta.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.948
ACACB	ACSS1	ENSLAFP00000011316	ENSLAFP00000009604	Acetyl-CoA carboxylase beta.	Acetyl-coenzyme A synthetase.	0.933
ACACB	ACSS2	ENSLAFP00000011316	ENSLAFP00000017841	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase short chain family member 2.	0.933
ACACB	DLAT	ENSLAFP00000011316	ENSLAFP00000008109	Acetyl-CoA carboxylase beta.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.924
ACACB	ME1	ENSLAFP00000011316	ENSLAFP00000004303	Acetyl-CoA carboxylase beta.	Malic enzyme.	0.414
ACACB	ME2	ENSLAFP00000011316	ENSLAFP00000001282	Acetyl-CoA carboxylase beta.	Malic enzyme.	0.414
ACACB	ME3	ENSLAFP00000011316	ENSLAFP00000005762	Acetyl-CoA carboxylase beta.	Malic enzyme.	0.414
ACAT1	ACACA	ENSLAFP00000027152	ENSLAFP00000002195	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase alpha.	0.947
ACAT1	ACACB	ENSLAFP00000027152	ENSLAFP00000011316	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase beta.	0.947

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