STRINGSTRING
ERBB2 ERBB2 BCL2 BCL2 PIK3R2 PIK3R2 PRKCB PRKCB PIK3CD PIK3CD PLCG2 PLCG2 BCL2L1 BCL2L1 GAB1 GAB1 EIF4E EIF4E AKT2 AKT2 PIK3CA PIK3CA PDGFD PDGFD BCL2L11 BCL2L11 PLCG1 PLCG1 PTEN PTEN PRKCA PRKCA FOXO3 FOXO3 GRB2 GRB2 JAK2 JAK2 PDGFB PDGFB GSK3B GSK3B FGF2 FGF2 SHC4 SHC4 SOS2 SOS2 RPS6KB2 RPS6KB2 SHC1 SHC1 MAPK1 MAPK1 SOS1 SOS1 RPS6 RPS6 PDGFRA PDGFRA EIF4E2 EIF4E2 RAF1 RAF1 MET MET PDGFC PDGFC SHC3 SHC3 EGF EGF RPS6KB1 RPS6KB1 EGFR EGFR KDR KDR ERBB3 ERBB3 IL6 IL6 MAP2K2 MAP2K2 MTOR MTOR PIK3CB PIK3CB PDGFRB PDGFRB NRG1 NRG1 AKT3 AKT3 ARAF ARAF GAS6 GAS6 PIK3R1 PIK3R1 NRAS NRAS BAD BAD TGFA TGFA HGF HGF FGFR3 FGFR3 VEGFA VEGFA JAK1 JAK1 PRKCG PRKCG PIK3R3 PIK3R3 NRG2 NRG2 NF1 NF1 SRC SRC IGF1R IGF1R STAT3 STAT3 EIF4E1B EIF4E1B EIF4EBP1 EIF4EBP1 FGFR2 FGFR2 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
PIK3R2Uncharacterized protein. (724 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCL2L1BCL2 like 1. (234 aa)
GAB1GRB2 associated binding protein 1. (694 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (197 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
FOXO3Forkhead box O3. (672 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
SHC1SHC adaptor protein 1. (583 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SHC3SHC adaptor protein 3. (463 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1168 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
IL6Interleukin 6. (212 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
NRG1Neuregulin 1. (700 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (607 aa)
GAS6Growth arrest specific 6. (672 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (206 aa)
TGFATransforming growth factor alpha. (129 aa)
HGFUncharacterized protein; Belongs to the peptidase S1 family. (480 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (215 aa)
JAK1Tyrosine-protein kinase. (1158 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
PIK3R3Uncharacterized protein. (509 aa)
NRG2Neuregulin 2. (625 aa)
NF1Neurofibromin 1. (2840 aa)
SRCTyrosine-protein kinase. (542 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (181 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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