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PLD1 PLD1 RAP1A RAP1A MYL9 MYL9 TIAM1 TIAM1 ATP1A2 ATP1A2 ATP1A4 ATP1A4 GABBR2 GABBR2 PIK3R2 PIK3R2 GRIN2D GRIN2D TSHR TSHR CALM3 CALM3 ADORA1 ADORA1 SOX9 SOX9 ADCY5 ADCY5 PIK3CD PIK3CD CNGA3 CNGA3 PDE10A PDE10A PLCE1 PLCE1 NPY1R NPY1R RRAS2 RRAS2 NPR1 NPR1 AKT2 AKT2 PIK3CA PIK3CA VIPR2 VIPR2 CNGB3 CNGB3 ATP1B4 ATP1B4 ADCY9 ADCY9 ACOX1 ACOX1 GIP GIP CALML5 CALML5 FXYD2 FXYD2 ADCY2 ADCY2 CREB3L1 CREB3L1 PPP1CB PPP1CB GCG GCG CFTR CFTR ADCY10 ADCY10 VIP VIP PRKACB PRKACB CNGB1 CNGB1 RYR2 RYR2 CAMK4 CAMK4 EDN1 EDN1 CALML3 CALML3 NFATC1 NFATC1 CREB3L2 CREB3L2 ADCY1 ADCY1 GLI3 GLI3 ADCY8 ADCY8 NFKB1 NFKB1 RHOA RHOA RAPGEF4 RAPGEF4 ADCY7 ADCY7 MAPK1 MAPK1 EDN3 EDN3 DRD1 DRD1 VAV2 VAV2 ATP1B3 ATP1B3 GRIA4 GRIA4 LHCGR LHCGR RAC2 RAC2 GRIN3A GRIN3A SLC9A1 SLC9A1 RAF1 RAF1 GRIA3 GRIA3 PAK1 PAK1 MC2R MC2R MAPK10 MAPK10 ADORA2A ADORA2A ADCY4 ADCY4 PDE3A PDE3A EP300 EP300 SST SST ATP2B4 ATP2B4 GNAI2 GNAI2 ATP1B1 ATP1B1 CREB1 CREB1 HTR4 HTR4 PPARA PPARA GRIA1 GRIA1 CNGA1 CNGA1 GHRL GHRL ADCY6 ADCY6 CACNA1S CACNA1S ADCYAP1 ADCYAP1 ADCY3 ADCY3 PPP1R12A PPP1R12A RAPGEF3 RAPGEF3 PLN PLN CREB3 CREB3 ATP2B1 ATP2B1 ATP2A2 ATP2A2 ROCK1 ROCK1 CREBBP CREBBP MAP2K2 MAP2K2 PIK3CB PIK3CB ATP1A1 ATP1A1 ABCC4 ABCC4 RAP1B RAP1B ATP2A1 ATP2A1 AKT3 AKT3 FSHR FSHR ATP2A3 ATP2A3 GHSR GHSR VAV3 VAV3 GABBR1 GABBR1 CREB3L4 CREB3L4 PIK3R1 PIK3R1 PDE4B PDE4B VAV1 VAV1 PTGER3 PTGER3 NFKBIA NFKBIA LOC100669226 LOC100669226 HCAR1 HCAR1 JUN JUN CAMK2A CAMK2A PPP1CA PPP1CA BAD BAD NPPA NPPA GNAI1 GNAI1 CALML4 CALML4 HTR1D HTR1D NPY NPY HTR1A HTR1A ADRB1 ADRB1 G3TUA1_LOXAF G3TUA1_LOXAF CNGA4 CNGA4 ATP1A3 ATP1A3 ACOX3 ACOX3 PRKACA PRKACA ADRB2 ADRB2 GNAI3 GNAI3 CGA CGA GPR119 GPR119 PIK3R3 PIK3R3 ATP2B2 ATP2B2 CNGA2 CNGA2 PDE3B PDE3B HCN2 HCN2 HTR1B HTR1B ROCK2 ROCK2 TSHB TSHB DRD5 DRD5 MAPK8 MAPK8 FFAR2 FFAR2 CHRM2 CHRM2 FSHB FSHB CREB5 CREB5 ATP1B2 ATP1B2 G3UF61_LOXAF G3UF61_LOXAF SSTR5 SSTR5 MAPK9 MAPK9 RELA RELA HTR1E HTR1E OXTR OXTR EDNRA EDNRA PTGER2 PTGER2 PDE4D PDE4D HTR1F HTR1F RRAS RRAS SSTR2 SSTR2 GRIN1 GRIN1 HTR6 HTR6 BDNF BDNF MAPK3 MAPK3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD1Phospholipase. (1075 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MYL9Myosin light chain 9. (172 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1016 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1033 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (789 aa)
PIK3R2Uncharacterized protein. (724 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1119 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (150 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
SOX9SRY-box transcription factor 9. (564 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (669 aa)
PDE10APhosphodiesterase. (490 aa)
PLCE1Phosphoinositide phospholipase C. (1887 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
RRAS2RAS related 2. (204 aa)
NPR1Guanylate cyclase. (1051 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (421 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (671 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (350 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
GIPGastric inhibitory polypeptide. (144 aa)
CALML5Calmodulin like 5. (149 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (75 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GCGGlucagon. (178 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1479 aa)
ADCY10Adenylate cyclase 10. (1613 aa)
VIPVasoactive intestinal peptide. (170 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CNGB1Cyclic nucleotide-binding domain-containing protein. (739 aa)
RYR2Ryanodine receptor 2. (4951 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (419 aa)
EDN1Endothelin 1. (202 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC1Nuclear factor of activated T cells 1. (786 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
GLI3GLI family zinc finger 3. (1586 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1245 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
RHOARas homolog family member A. (193 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
EDN3Uncharacterized protein. (205 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (435 aa)
VAV2Vav guanine nucleotide exchange factor 2. (866 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (901 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (631 aa)
RAC2Rac family small GTPase 2. (194 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (785 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (825 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
MC2RMelanocortin 2 receptor. (297 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (400 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PDE3APhosphodiesterase. (807 aa)
EP300E1A binding protein p300. (2420 aa)
SSTSomatostatin. (116 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1208 aa)
GNAI2G protein subunit alpha i2. (354 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (687 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1685 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (907 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CREBBPCREB binding protein. (2433 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1017 aa)
ABCC4ATP binding cassette subfamily C member 4. (1306 aa)
RAP1BUncharacterized protein. (184 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1044 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (691 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1039 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (933 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (375 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDE4BPhosphodiesterase. (642 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PTGER3Prostaglandin E receptor 3. (333 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LOC100669226Uncharacterized protein. (247 aa)
HCAR1Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (299 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
BADBCL2 associated agonist of cell death. (206 aa)
NPPANatriuretic peptide A. (153 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CALML4Calmodulin like 4. (153 aa)
HTR1DG_PROTEIN_RECEP_F1_2 domain-containing protein. (377 aa)
NPYNeuropeptide Y. (98 aa)
HTR1A5-hydroxytryptamine receptor 1A. (419 aa)
ADRB1Adrenoceptor beta 1; Belongs to the G-protein coupled receptor 1 family. (313 aa)
G3TUA1_LOXAFG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (318 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (500 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1014 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (699 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
GNAI3G protein subunit alpha i3. (353 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (121 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
PIK3R3Uncharacterized protein. (509 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (662 aa)
PDE3BPhosphodiesterase. (1112 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (732 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TSHBThyroid stimulating hormone beta subunit. (138 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (476 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (316 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
FSHBFollicle stimulating hormone subunit beta. (135 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (293 aa)
G3UF61_LOXAFUncharacterized protein. (393 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (368 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
HTR1E5-hydroxytryptamine receptor 1E. (344 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (382 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (425 aa)
PTGER2Prostaglandin E receptor 2. (272 aa)
PDE4DPhosphodiesterase. (585 aa)
HTR1FG_PROTEIN_RECEP_F1_2 domain-containing protein. (366 aa)
RRASRAS related. (219 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GRIN1ANF_receptor domain-containing protein. (422 aa)
HTR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (436 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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