STRINGSTRING
PIK3R2 PIK3R2 PIP4K2A PIP4K2A OCRL OCRL INPPL1 INPPL1 PRKCB PRKCB CALM3 CALM3 PIK3CD PIK3CD INPP5F INPP5F PLCE1 PLCE1 PLCG2 PLCG2 MTMR7 MTMR7 IPPK IPPK PLCB1 PLCB1 PI4KA PI4KA ITPR1 ITPR1 PIK3CA PIK3CA MTMR4 MTMR4 PIK3C2A PIK3C2A PIP4P1 PIP4P1 PLCG1 PLCG1 CALML5 CALML5 IMPAD1 IMPAD1 IPMK IPMK PTEN PTEN ITPR2 ITPR2 PI4KB PI4KB PRKCA PRKCA PLCB4 PLCB4 MTM1 MTM1 CDS2 CDS2 DGKE DGKE CALML3 CALML3 PPIP5K2 PPIP5K2 PIP5K1B PIP5K1B INPP1 INPP1 DGKI DGKI MTMR2 MTMR2 PLCB3 PLCB3 DGKH DGKH ITPKC ITPKC MTMR14 MTMR14 PI4K2A PI4K2A DGKD DGKD PIP4P2 PIP4P2 ITPKB ITPKB MTMR3 MTMR3 PLCB2 PLCB2 SYNJ1 SYNJ1 SYNJ2 SYNJ2 IP6K3 IP6K3 PLCD4 PLCD4 IP6K1 IP6K1 PIP5K1A PIP5K1A PIK3C2G PIK3C2G PIK3CB PIK3CB INPP5D INPP5D PIKFYVE PIKFYVE PIK3C2B PIK3C2B INPP5B INPP5B INPP4B INPP4B ITPKA ITPKA DGKA DGKA INPP5A INPP5A PIK3R1 PIK3R1 IMPA1 IMPA1 ITPR3 ITPR3 CALML4 CALML4 DGKZ DGKZ PPIP5K1 PPIP5K1 CDS1 CDS1 PRKCG PRKCG PIK3R3 PIK3R3 PLCD1 PLCD1 PIP5K1C PIP5K1C SACM1L SACM1L MTMR6 MTMR6 PIP4K2B PIP4K2B CDIPT CDIPT PIP4K2C PIP4K2C MTMR1 MTMR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R2Uncharacterized protein. (724 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (405 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1265 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (150 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1102 aa)
PLCE1Phosphoinositide phospholipase C. (1887 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MTMR7Myotubularin related protein 7. (660 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (491 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2043 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MTMR4Myotubularin related protein 4. (1198 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1693 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
CALML5Calmodulin like 5. (149 aa)
IMPAD1Inositol monophosphatase domain containing 1. (357 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (399 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ITPR2Ion_trans domain-containing protein. (495 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (802 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
MTM1Myotubularin 1. (603 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (444 aa)
DGKEDiacylglycerol kinase. (567 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1222 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
INPP1Inositol polyphosphate-1-phosphatase. (401 aa)
DGKIDiacylglycerol kinase. (855 aa)
MTMR2Myotubularin related protein 2. (617 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
DGKHDiacylglycerol kinase. (1104 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (298 aa)
MTMR14Myotubularin related protein 14. (649 aa)
PI4K2API3K/PI4K domain-containing protein. (479 aa)
DGKDDiacylglycerol kinase. (1169 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (620 aa)
MTMR3Myotubularin related protein 3. (1204 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
SYNJ1Synaptojanin 1. (1581 aa)
SYNJ2Synaptojanin 2. (1467 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (404 aa)
PLCD4Phosphoinositide phospholipase C. (763 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (462 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (528 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1507 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1191 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2105 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1633 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (740 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (939 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
DGKADiacylglycerol kinase. (735 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (415 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IMPA1Inositol-1-monophosphatase. (277 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
CALML4Calmodulin like 4. (153 aa)
DGKZDiacylglycerol kinase. (1118 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1375 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
PIK3R3Uncharacterized protein. (509 aa)
PLCD1Phosphoinositide phospholipase C. (751 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (623 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (587 aa)
MTMR6Myotubularin related protein 6. (625 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (424 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (422 aa)
MTMR1Myotubularin related protein 1. (620 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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