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PLD1 PLD1 BCL2 BCL2 MAP3K5 MAP3K5 CERS5 CERS5 PIK3R2 PIK3R2 PRKCB PRKCB ADORA1 ADORA1 SGPP2 SGPP2 PIK3CD PIK3CD GNAQ GNAQ GNA13 GNA13 DEGS1 DEGS1 PLCB1 PLCB1 AKT2 AKT2 PIK3CA PIK3CA SMPD2 SMPD2 FCER1A FCER1A ADORA3 ADORA3 MAPK14 MAPK14 MAPK13 MAPK13 PTEN PTEN PRKCE PRKCE PRKCA PRKCA TRADD TRADD PLCB4 PLCB4 CERS3 CERS3 NOS3 NOS3 S1PR3 S1PR3 TP53 TP53 TNF TNF SGPL1 SGPL1 PPP2R5B PPP2R5B BID BID ASAH1 ASAH1 PLCB3 PLCB3 NFKB1 NFKB1 RHOA RHOA PPP2R3C PPP2R3C MAPK1 MAPK1 PPP2R5A PPP2R5A KNG1 KNG1 ACER2 ACER2 RAC2 RAC2 ABCC1 ABCC1 RAF1 RAF1 PLCB2 PLCB2 SPTLC1 SPTLC1 MAPK10 MAPK10 PPP2R5E PPP2R5E CERS4 CERS4 ACER1 ACER1 GNAI2 GNAI2 GNA12 GNA12 SPTLC3 SPTLC3 PPP2R3A PPP2R3A PPP2R2B PPP2R2B SPHK2 SPHK2 ROCK1 ROCK1 ASAH2 ASAH2 MAP2K2 MAP2K2 PIK3CB PIK3CB PPP2R2D PPP2R2D SGMS2 SGMS2 MAPK12 MAPK12 PPP2CA PPP2CA AKT3 AKT3 OPRD1 OPRD1 PPP2R1A PPP2R1A PIK3R1 PIK3R1 PRKCZ PRKCZ NRAS NRAS PPP2R2A PPP2R2A TRAF2 TRAF2 G3TP46_LOXAF G3TP46_LOXAF GNAI1 GNAI1 SPHK1 SPHK1 PPP2R5C PPP2R5C PPP2R1B PPP2R1B S1PR5 S1PR5 SMPD1 SMPD1 PDPK1 PDPK1 GNAI3 GNAI3 PRKCG PRKCG S1PR2 S1PR2 CTSD CTSD SPTLC2 SPTLC2 BDKRB2 BDKRB2 PIK3R3 PIK3R3 ROCK2 ROCK2 NSMAF NSMAF PPP2CB PPP2CB MAPK8 MAPK8 DEGS2 DEGS2 SGPP1 SGPP1 MAPK9 MAPK9 RELA RELA SGMS1 SGMS1 S1PR4 S1PR4 PPP2R5D PPP2R5D GAB2 GAB2 CERS2 CERS2 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD1Phospholipase. (1075 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
CERS5Ceramide synthase 5. (350 aa)
PIK3R2Uncharacterized protein. (724 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
GNAQG protein subunit alpha q. (316 aa)
GNA13G protein subunit alpha 13. (284 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (296 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (416 aa)
FCER1AFc fragment of IgE receptor Ia. (253 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (319 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (607 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
CERS3Ceramide synthase 3. (335 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1199 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (435 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (394 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
RHOARas homolog family member A. (193 aa)
PPP2R3CEF-hand_13 domain-containing protein. (453 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (426 aa)
KNG1Kininogen 1. (631 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
RAC2Rac family small GTPase 2. (194 aa)
ABCC1ATP binding cassette subfamily C member 1. (1541 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CERS4Ceramide synthase 4. (389 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (233 aa)
GNAI2G protein subunit alpha i2. (354 aa)
GNA12G protein subunit alpha 12. (373 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (498 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1148 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
SPHK2Sphingosine kinase 2. (615 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ASAH2Neutral ceramidase. (677 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (491 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (509 aa)
G3TP46_LOXAFEF-hand domain-containing protein. (250 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SPHK1Sphingosine kinase 1. (386 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (697 aa)
S1PR5Sphingosine-1-phosphate receptor 5. (397 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
GNAI3G protein subunit alpha i3. (353 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
S1PR2Sphingosine-1-phosphate receptor 2. (352 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (377 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (560 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (371 aa)
PIK3R3Uncharacterized protein. (509 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (901 aa)
PPP2CBSerine/threonine-protein phosphatase. (276 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (438 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (379 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (597 aa)
GAB2GRB2 associated binding protein 2. (672 aa)
CERS2Ceramide synthase 2. (389 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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