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| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | E2F3 | E2F transcription factor 3. (460 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa) |
| | CDC14A | Cell division cycle 14A. (581 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (497 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | RAD21 | RAD21 cohesin complex component. (635 aa) |
| | CDC16 | Cell division cycle 16. (624 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | ANAPC13 | Anaphase promoting complex subunit 13. (74 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (855 aa) |
| | CHEK2 | Checkpoint kinase 2. (550 aa) |
| | ZBTB17 | Zinc finger and BTB domain containing 17. (792 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (834 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | ORC5 | Origin recognition complex subunit 5. (434 aa) |
| | SKP2 | S-phase kinase associated protein 2. (424 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (487 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | E2F5 | E2F transcription factor 5. (343 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (564 aa) |
| | CDC25A | Cell division cycle 25A. (526 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ABL1 | Tyrosine-protein kinase. (1142 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (743 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | TFDP1 | Transcription factor. (407 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2085 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1061 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1137 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (146 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (251 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (361 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | CDC7 | Cell division cycle 7. (542 aa) |
| | TFDP2 | Transcription factor. (419 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (226 aa) |
| | PTTG1 | Uncharacterized protein. (191 aa) |
| | PRKDC | Uncharacterized protein. (221 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (862 aa) |
| | CDC27 | Cell division cycle 27. (831 aa) |
| | BUB1B | Uncharacterized protein. (1061 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (325 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1235 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1218 aa) |
| | ORC3 | Origin recognition complex subunit 3. (715 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | CREBBP | CREB binding protein. (2433 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | E2F1 | E2F transcription factor 1. (429 aa) |
| | STAG1 | Stromal antigen 1. (1258 aa) |
| | CDC14C | Cell division cycle 14C. (485 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | LOC100668722 | HORMA domain-containing protein. (205 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (291 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (131 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa) |
| | CDC25B | Cell division cycle 25B. (579 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1236 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (243 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | LOC100667589 | HORMA domain-containing protein. (205 aa) |
| | E2F4 | E2F transcription factor 4. (404 aa) |
| | E2F2 | E2F transcription factor 2. (442 aa) |
| | DBF4 | DBF4 zinc finger. (670 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | TTK | TTK protein kinase. (841 aa) |
| | RB1 | RB transcriptional corepressor 1. (925 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (425 aa) |
