STRINGSTRING
DVL3 DVL3 CASTOR1 CASTOR1 RHEB RHEB PIK3R2 PIK3R2 PRKCB PRKCB WNT7A WNT7A WNT7B WNT7B PIK3CD PIK3CD NPRL2 NPRL2 EIF4E EIF4E WNT5A WNT5A AKT2 AKT2 PIK3CA PIK3CA TELO2 TELO2 FZD6 FZD6 ATP6V1E1 ATP6V1E1 WNT10B WNT10B MLST8 MLST8 IKBKB IKBKB RPS6KA1 RPS6KA1 CAB39 CAB39 MIOS MIOS PTEN PTEN SKP2 SKP2 PRKCA PRKCA GRB2 GRB2 ATP6V1H ATP6V1H LAMTOR1 LAMTOR1 SEH1L SEH1L RPS6KA3 RPS6KA3 WNT8A WNT8A RPS6KA6 RPS6KA6 TNF TNF GSK3B GSK3B LPIN1 LPIN1 TSC1 TSC1 ATP6V1F ATP6V1F SOS2 SOS2 RPS6KB2 RPS6KB2 LPIN2 LPIN2 EIF4B EIF4B TTI1 TTI1 RHOA RHOA WNT16 WNT16 MAPK1 MAPK1 STRADA STRADA SOS1 SOS1 RPS6 RPS6 WNT11 WNT11 EIF4E2 EIF4E2 STK11 STK11 RAF1 RAF1 FZD3 FZD3 ATP6V1C1 ATP6V1C1 DEPDC5 DEPDC5 WNT10A WNT10A FNIP2 FNIP2 SGK1 SGK1 PRKAA2 PRKAA2 LAMTOR5 LAMTOR5 DEPTOR DEPTOR ATP6V1D ATP6V1D ATP6V1G1 ATP6V1G1 ATP6V1A ATP6V1A WNT3 WNT3 ATP6V1E2 ATP6V1E2 RPS6KB1 RPS6KB1 WDR24 WDR24 MAPKAP1 MAPKAP1 SEC13 SEC13 STRADB STRADB CHUK CHUK FLCN FLCN TSC2 TSC2 GRB10 GRB10 MAP2K2 MAP2K2 MTOR MTOR PIK3CB PIK3CB LAMTOR3 LAMTOR3 WNT5B WNT5B ULK2 ULK2 CLIP1 CLIP1 WNT8B WNT8B LRP6 LRP6 AKT3 AKT3 WNT9A WNT9A SLC38A9 SLC38A9 WNT6 WNT6 PRKAA1 PRKAA1 CAB39L CAB39L SLC3A2 SLC3A2 PIK3R1 PIK3R1 INS INS NRAS NRAS ATP6V1G2 ATP6V1G2 FNIP1 FNIP1 RRAGA RRAGA WNT2B WNT2B DVL2 DVL2 ATP6V1G3 ATP6V1G3 WNT2 WNT2 TBC1D7 TBC1D7 WNT9B WNT9B WNT3A WNT3A FZD5 FZD5 WDR59 WDR59 PRR5 PRR5 ATP6V1B2 ATP6V1B2 PDPK1 PDPK1 SLC7A5 SLC7A5 PRKCG PRKCG PIK3R3 PIK3R3 NPRL3 NPRL3 LAMTOR2 LAMTOR2 DDIT4 DDIT4 FZD10 FZD10 RRAGB RRAGB FZD1 FZD1 SESN2 SESN2 LPIN3 LPIN3 IRS1 IRS1 RICTOR RICTOR FZD7 FZD7 IGF1R IGF1R EIF4E1B EIF4E1B FZD4 FZD4 RRAGC RRAGC INSR INSR EIF4EBP1 EIF4EBP1 FZD2 FZD2 RNF152 RNF152 RPS6KA2 RPS6KA2 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DVL3Dishevelled segment polarity protein 3. (715 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (331 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PIK3R2Uncharacterized protein. (724 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (493 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TELO2Telomere maintenance 2. (834 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (229 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (703 aa)
CAB39Calcium binding protein 39. (341 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
RPS6KA3Ribosomal protein S6 kinase. (737 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (703 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
LPIN1Lipin 1. (929 aa)
TSC1TSC complex subunit 1. (869 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
LPIN2Lipin 2. (896 aa)
EIF4BEukaryotic translation initiation factor 4B. (612 aa)
TTI1TELO2 interacting protein 1. (1087 aa)
RHOARas homolog family member A. (193 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
STRADASTE20 related adaptor alpha. (431 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
STK11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (383 aa)
DEPDC5DEP domain-containing protein. (1593 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FNIP2Folliculin interacting protein 2. (1079 aa)
SGK1Non-specific serine/threonine protein kinase. (525 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
DEPTORDEP domain containing MTOR interacting protein. (402 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WDR24WD repeat domain 24. (790 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (321 aa)
STRADBSTE20 related adaptor beta. (419 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
FLCNFolliculin. (578 aa)
TSC2TSC complex subunit 2. (1810 aa)
GRB10Growth factor receptor bound protein 10. (430 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (121 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
ULK2Protein kinase domain-containing protein. (1030 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1438 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
SLC38A9Solute carrier family 38 member 9. (562 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CAB39LCalcium binding protein 39 like. (336 aa)
SLC3A2Solute carrier family 3 member 2. (542 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (117 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
RRAGARas related GTP binding A. (313 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
TBC1D7TBC1 domain family member 7. (294 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (197 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WDR59WD repeat domain 59. (993 aa)
PRR5Proline rich 5. (372 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (510 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
SLC7A5Solute carrier family 7 member 5. (510 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
PIK3R3Uncharacterized protein. (509 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (581 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (385 aa)
RRAGBRas related GTP binding B. (376 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (629 aa)
SESN2Sestrin 2. (485 aa)
LPIN3Lipin 3. (860 aa)
IRS1Insulin receptor substrate 1. (1119 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1733 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (593 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (181 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
RRAGCRas related GTP binding C. (403 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (513 aa)
RNF152Ring finger protein 152. (203 aa)
RPS6KA2Ribosomal protein S6 kinase. (737 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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