STRINGSTRING
CTSZ CTSZ BCL2 BCL2 MAP3K5 MAP3K5 LOC100667382 LOC100667382 PIK3R2 PIK3R2 CTSC CTSC ACTB ACTB NTRK1 NTRK1 BAK1 BAK1 PIK3CD PIK3CD CTSW CTSW BCL2L1 BCL2L1 PARP4 PARP4 LMNA LMNA AKT2 AKT2 BIRC2 BIRC2 ITPR1 ITPR1 PIK3CA PIK3CA SEPTIN4-2 SEPTIN4-2 CTSH CTSH BCL2L11 BCL2L11 IKBKB IKBKB CASP2 CASP2 MAP3K14 MAP3K14 ITPR2 ITPR2 PARP3 PARP3 BIRC3 BIRC3 G3SXI4_LOXAF G3SXI4_LOXAF TRADD TRADD BIRC5 BIRC5 CYCS CYCS CTSB CTSB TP53 TP53 TNF TNF PARP1 PARP1 DAB2IP DAB2IP CTSO CTSO G3T189_LOXAF G3T189_LOXAF BID BID ATM ATM ERN1 ERN1 AIFM1 AIFM1 TUBA4A TUBA4A TUBA8 TUBA8 NFKB1 NFKB1 GADD45A GADD45A MAPK1 MAPK1 RIPK1 RIPK1 CASP7 CASP7 MCL1 MCL1 CTSS CTSS PRF1 PRF1 RAF1 RAF1 BCL2A1 BCL2A1 ATF4 ATF4 SPTA1 SPTA1 MAPK10 MAPK10 FASLG FASLG G3TBD7_LOXAF G3TBD7_LOXAF TNFSF10 TNFSF10 PTPN13 PTPN13 APAF1 APAF1 CHUK CHUK MAP2K2 MAP2K2 PIK3CB PIK3CB CASP9 CASP9 CTSF CTSF G3THD9_LOXAF G3THD9_LOXAF AKT3 AKT3 GADD45B GADD45B DFFB DFFB LMNB1 LMNB1 PIK3R1 PIK3R1 CASP8 CASP8 HTRA2 HTRA2 NFKBIA NFKBIA NRAS NRAS JUN JUN TRAF2 TRAF2 CASP12 CASP12 BAD BAD ITPR3 ITPR3 EIF2AK3 EIF2AK3 CFLAR CFLAR PARP2 PARP2 IKBKG IKBKG CASP3 CASP3 G3TUP8_LOXAF G3TUP8_LOXAF G3TVP2_LOXAF G3TVP2_LOXAF G3TW84_LOXAF G3TW84_LOXAF NGF NGF LOC100665585 LOC100665585 LOC104847000 LOC104847000 PDPK1 PDPK1 XIAP XIAP G3U0W1_LOXAF G3U0W1_LOXAF GADD45G GADD45G CTSD CTSD LOC100661985 LOC100661985 CTSK CTSK EIF2S1 EIF2S1 PIK3R3 PIK3R3 G3U6K2_LOXAF G3U6K2_LOXAF CASP6 CASP6 DDIT3 DDIT3 MAPK8 MAPK8 IL3RA IL3RA SPTAN1 SPTAN1 LOC100654286 LOC100654286 DIABLO DIABLO CAPN1 CAPN1 MAPK9 MAPK9 G3UFG8_LOXAF G3UFG8_LOXAF RELA RELA HRK HRK G3UJ54_LOXAF G3UJ54_LOXAF TUBA1B TUBA1B CAPN2 CAPN2 ENDOG ENDOG ACTG1 ACTG1 G3ULI4_LOXAF G3ULI4_LOXAF MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSZCathepsin Z; Belongs to the peptidase C1 family. (305 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
LOC100667382Uncharacterized protein; Belongs to the peptidase C1 family. (335 aa)
PIK3R2Uncharacterized protein. (724 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
ACTBActin beta. (381 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (376 aa)
BCL2L1BCL2 like 1. (234 aa)
PARP4Poly [ADP-ribose] polymerase. (1241 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BIRC2Baculoviral IAP repeat containing 2. (606 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SEPTIN4-2Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (197 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
ITPR2Ion_trans domain-containing protein. (495 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
G3SXI4_LOXAFUncharacterized protein. (895 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
BIRC5Baculoviral IAP repeat containing 5. (140 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (342 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (974 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (277 aa)
G3T189_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (955 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (146 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (265 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (341 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (342 aa)
PRF1Perforin 1. (555 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
BCL2A1BCL2 related protein A1. (175 aa)
ATF4Activating transcription factor 4. (379 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2392 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (277 aa)
G3TBD7_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2267 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (450 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (453 aa)
G3THD9_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (245 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
DFFBDNA fragmentation factor subunit beta. (340 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (466 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (478 aa)
HTRA2HtrA serine peptidase 2. (457 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (509 aa)
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (412 aa)
BADBCL2 associated agonist of cell death. (206 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1010 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
PARP2Poly [ADP-ribose] polymerase. (569 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (281 aa)
G3TUP8_LOXAFUncharacterized protein; Belongs to the peptidase C1 family. (335 aa)
G3TVP2_LOXAFUncharacterized protein. (145 aa)
G3TW84_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (242 aa)
LOC100665585Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
LOC104847000Peptidase S1 domain-containing protein. (225 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
G3U0W1_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (377 aa)
LOC100661985Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PIK3R3Uncharacterized protein. (509 aa)
G3U6K2_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (276 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
IL3RAUncharacterized protein. (388 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2478 aa)
LOC100654286Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
DIABLOUncharacterized protein. (237 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (703 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
G3UFG8_LOXAFFibronectin type-III domain-containing protein. (762 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
HRKHarakiri, BCL2 interacting protein. (91 aa)
G3UJ54_LOXAFPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (623 aa)
ENDOGEndonuclease. (226 aa)
ACTG1Actin gamma 1. (379 aa)
G3ULI4_LOXAFUncharacterized protein; Belongs to the peptidase C14A family. (223 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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