STRINGSTRING
RHEB RHEB PIK3R2 PIK3R2 ADCY5 ADCY5 PIK3CD PIK3CD SESN3 SESN3 ATG101 ATG101 EIF4E EIF4E AKT2 AKT2 PIK3CA PIK3CA ADIPOR1 ADIPOR1 ADIPOQ ADIPOQ ADCY9 ADCY9 ADCY2 ADCY2 PRKAG1 PRKAG1 CREB3L1 CREB3L1 PRKAB1 PRKAB1 CAT CAT FOXO3 FOXO3 ATF2 ATF2 PRKACB PRKACB CAMK4 CAMK4 SOD2 SOD2 TP53 TP53 EHMT2 EHMT2 TSC1 TSC1 CREB3L2 CREB3L2 ADCY1 ADCY1 RPS6KB2 RPS6KB2 ADCY8 ADCY8 SIRT1 SIRT1 NFKB1 NFKB1 ADCY7 ADCY7 FOXO1 FOXO1 EIF4E2 EIF4E2 STK11 STK11 PRKAG2 PRKAG2 ATF4 ATF4 ADCY4 ADCY4 PRKAA2 PRKAA2 PPARGC1A PPARGC1A CREB1 CREB1 ADCY6 ADCY6 RPS6KB1 RPS6KB1 APPL1 APPL1 ADCY3 ADCY3 CREB3 CREB3 TSC2 TSC2 MTOR MTOR PIK3CB PIK3CB KL KL PRKAG3 PRKAG3 AKT3 AKT3 ATG5 ATG5 IRS2 IRS2 PRKAA1 PRKAA1 CREB3L4 CREB3L4 PIK3R1 PIK3R1 INS INS NRAS NRAS ATF6B ATF6B SESN1 SESN1 ADIPOR2 ADIPOR2 PRKACA PRKACA PIK3R3 PIK3R3 PRKAB2 PRKAB2 CAMKK2 CAMKK2 PPARG PPARG SESN2 SESN2 IRS1 IRS1 IGF1R IGF1R EIF4E1B EIF4E1B CREB5 CREB5 INSR INSR RELA RELA EIF4EBP1 EIF4EBP1 RB1CC1 RB1CC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHEBRas homolog, mTORC1 binding. (184 aa)
PIK3R2Uncharacterized protein. (724 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
SESN3Sestrin 3. (493 aa)
ATG101Autophagy related 101. (218 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (314 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
FOXO3Forkhead box O3. (672 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (487 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (419 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (220 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1225 aa)
TSC1TSC complex subunit 1. (869 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1245 aa)
SIRT1Sirtuin 1. (605 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
FOXO1FOXO-TAD domain-containing protein. (374 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
STK11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (326 aa)
ATF4Activating transcription factor 4. (379 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
TSC2TSC complex subunit 2. (1810 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
KLKlotho. (967 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
IRS2Insulin receptor substrate 2. (1342 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (375 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ATF6BActivating transcription factor 6 beta. (701 aa)
SESN1Sestrin 1. (551 aa)
ADIPOR2Adiponectin receptor 2. (387 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PIK3R3Uncharacterized protein. (509 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (575 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SESN2Sestrin 2. (485 aa)
IRS1Insulin receptor substrate 1. (1119 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (181 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
RB1CC1ATG11 domain-containing protein. (1595 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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