STRINGSTRING
SMAD2 SMAD2 E2F3 E2F3 SLC25A31 SLC25A31 CXCL8 CXCL8 RASSF5 RASSF5 RHEB RHEB PIK3R2 PIK3R2 CCNA1 CCNA1 CALM3 CALM3 IL1A IL1A MYC MYC PIK3CD PIK3CD CCNE2 CCNE2 SLC25A6 SLC25A6 LOC100662084 LOC100662084 TRPM7 TRPM7 TGFB2 TGFB2 LIN9 LIN9 LIN52 LIN52 RBBP4 RBBP4 RRAS2 RRAS2 GATA4 GATA4 FOXM1 FOXM1 AKT2 AKT2 ITPR1 ITPR1 G3SRG9_LOXAF G3SRG9_LOXAF PIK3CA PIK3CA TGFBR2 TGFBR2 CHEK2 CHEK2 ZFP36L2 ZFP36L2 CALML5 CALML5 MAP2K6 MAP2K6 MCU MCU CCNB2 CCNB2 TRAF3IP2 TRAF3IP2 MAPK14 MAPK14 MAPK13 MAPK13 PTEN PTEN PPP1CB PPP1CB G3SWF6_LOXAF G3SWF6_LOXAF ITPR2 ITPR2 FOXO3 FOXO3 MDM2 MDM2 E2F5 E2F5 RAD9B RAD9B CDC25A CDC25A FBXW11 FBXW11 LIN54 LIN54 RAD1 RAD1 CALML3 CALML3 TP53 TP53 TGFB1 TGFB1 CCND1 CCND1 ATM ATM NFATC1 NFATC1 TSC1 TSC1 RAD9A RAD9A RBL2 RBL2 SIRT1 SIRT1 NFKB1 NFKB1 GADD45A GADD45A CCNA2 CCNA2 VDAC2 VDAC2 RAD50 RAD50 G3T4P5_LOXAF G3T4P5_LOXAF MAPK1 MAPK1 FOXO1 FOXO1 CDK4 CDK4 MRAS MRAS SERPINE1 SERPINE1 PPP3CB PPP3CB RAF1 RAF1 CCNE1 CCNE1 LIN37 LIN37 VDAC3 VDAC3 HIPK3 HIPK3 IGFBP3 IGFBP3 PPID PPID NFATC4 NFATC4 NFATC3 NFATC3 NFATC2 NFATC2 TSC2 TSC2 ATR ATR IL6 IL6 MAP2K2 MAP2K2 MTOR MTOR PIK3CB PIK3CB PPP3CA PPP3CA MAPK12 MAPK12 CCND2 CCND2 AKT3 AKT3 GADD45B GADD45B BTRC BTRC NBN NBN G3TJB3_LOXAF G3TJB3_LOXAF HUS1 HUS1 E2F1 E2F1 PIK3R1 PIK3R1 CDK6 CDK6 MAPKAPK2 MAPKAPK2 NRAS NRAS PPP3R1 PPP3R1 G3TMJ7_LOXAF G3TMJ7_LOXAF CCND3 CCND3 CDKN2B CDKN2B RBL1 RBL1 PPP1CA PPP1CA CHEK1 CHEK1 ITPR3 ITPR3 TGFB3 TGFB3 CALML4 CALML4 HIPK4 HIPK4 SLC25A5 SLC25A5 MRE11 MRE11 MYBL2 MYBL2 E2F4 E2F4 G3TWU7_LOXAF G3TWU7_LOXAF E2F2 E2F2 HIPK1 HIPK1 GADD45G GADD45G PIK3R3 PIK3R3 CDKN1A CDKN1A PPP3CC PPP3CC TGFBR1 TGFBR1 G3U6B9_LOXAF G3U6B9_LOXAF MAP2K3 MAP2K3 G3UAD3_LOXAF G3UAD3_LOXAF G3UB77_LOXAF G3UB77_LOXAF CDK1 CDK1 G3UCD5_LOXAF G3UCD5_LOXAF ZFP36L1 ZFP36L1 CAPN1 CAPN1 RELA RELA VDAC1 VDAC1 G3UGQ5_LOXAF G3UGQ5_LOXAF EIF4EBP1 EIF4EBP1 G3UK64_LOXAF G3UK64_LOXAF CAPN2 CAPN2 RRAS RRAS RB1 RB1 CCNB1 CCNB1 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (467 aa)
E2F3E2F transcription factor 3. (460 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (319 aa)
CXCL8Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
RASSF5Ras association domain family member 5. (414 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PIK3R2Uncharacterized protein. (724 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (150 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
LOC100662084Ig-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1873 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
LIN9Lin-9 DREAM MuvB core complex component. (542 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
RRAS2RAS related 2. (204 aa)
GATA4GATA binding protein 4. (383 aa)
FOXM1Forkhead box M1. (761 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
G3SRG9_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CHEK2Checkpoint kinase 2. (550 aa)
ZFP36L2ZFP36 ring finger protein like 2. (497 aa)
CALML5Calmodulin like 5. (149 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MCUMitochondrial calcium uniporter. (354 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
TRAF3IP2TRAF3 interacting protein 2. (562 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
G3SWF6_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (338 aa)
ITPR2Ion_trans domain-containing protein. (495 aa)
FOXO3Forkhead box O3. (672 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)
E2F5E2F transcription factor 5. (343 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (406 aa)
CDC25ACell division cycle 25A. (526 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
RAD1RAD1 checkpoint DNA exonuclease. (280 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
NFATC1Nuclear factor of activated T cells 1. (786 aa)
TSC1TSC complex subunit 1. (869 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
RBL2RB transcriptional corepressor like 2. (1137 aa)
SIRT1Sirtuin 1. (605 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (146 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (361 aa)
VDAC2Voltage dependent anion channel 2. (296 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
G3T4P5_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
FOXO1FOXO-TAD domain-containing protein. (374 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (226 aa)
MRASMuscle RAS oncogene homolog. (209 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (400 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
VDAC3Voltage dependent anion channel 3. (283 aa)
HIPK3Homeodomain interacting protein kinase 3. (1214 aa)
IGFBP3Insulin like growth factor binding protein 3. (296 aa)
PPIDPeptidylprolyl isomerase D. (372 aa)
NFATC4Nuclear factor of activated T cells 4. (705 aa)
NFATC3Nuclear factor of activated T cells 3. (1067 aa)
NFATC2Nuclear factor of activated T cells 2. (926 aa)
TSC2TSC complex subunit 2. (1810 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
IL6Interleukin 6. (212 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (593 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
G3TJB3_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (320 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
E2F1E2F transcription factor 1. (429 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAPKAPK2MAPK activated protein kinase 2. (308 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP3R1Uncharacterized protein. (169 aa)
G3TMJ7_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (237 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (291 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CALML4Calmodulin like 4. (153 aa)
HIPK4Homeodomain interacting protein kinase 4. (603 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
MYBL2MYB proto-oncogene like 2. (701 aa)
E2F4E2F transcription factor 4. (404 aa)
G3TWU7_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
E2F2E2F transcription factor 2. (442 aa)
HIPK1Homeodomain interacting protein kinase 1. (1211 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PIK3R3Uncharacterized protein. (509 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PPP3CCSerine/threonine-protein phosphatase. (512 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (482 aa)
G3U6B9_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (367 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
G3UAD3_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (379 aa)
G3UB77_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (249 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
G3UCD5_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (368 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (703 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
VDAC1Voltage dependent anion channel 1. (287 aa)
G3UGQ5_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (316 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
G3UK64_LOXAFIg-like domain-containing protein; Belongs to the MHC class I family. (308 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (623 aa)
RRASRAS related. (219 aa)
RB1RB transcriptional corepressor 1. (925 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (425 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.