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EPHA3 EPHA3 EFNA1 EFNA1 MYL9 MYL9 PIK3R2 PIK3R2 BOC BOC TRPC4 TRPC4 SEMA3C SEMA3C SEMA5B SEMA5B PIK3CD PIK3CD PARD6G PARD6G PLCG2 PLCG2 PTPN11 PTPN11 WNT5A WNT5A LIMK2 LIMK2 SEMA4A SEMA4A NRP1 NRP1 PIK3CA PIK3CA DPYSL2 DPYSL2 TRPC3 TRPC3 SEMA5A SEMA5A EFNB3 EFNB3 EFNA5 EFNA5 NTN4 NTN4 PARD6B PARD6B TRPC1 TRPC1 MYL12B MYL12B SEMA6A SEMA6A PLCG1 PLCG1 NTN1 NTN1 PDK1 PDK1 UNC5D UNC5D SSH2 SSH2 SEMA4B SEMA4B PAK4 PAK4 UNC5B UNC5B SRGAP3 SRGAP3 PAK3 PAK3 PRKCA PRKCA CDC42 CDC42 FES FES SEMA6D SEMA6D SEMA3F SEMA3F LRRC4C LRRC4C CXCR4 CXCR4 EPHB2 EPHB2 BMP7 BMP7 ABLIM3 ABLIM3 PAK2 PAK2 ABL1 ABL1 PARD6A PARD6A ROBO1 ROBO1 EPHA2 EPHA2 GSK3B GSK3B PAK5 PAK5 SEMA3G SEMA3G CDK5 CDK5 NTNG1 NTNG1 RHOA RHOA SEMA3E SEMA3E SLIT3 SLIT3 MAPK1 MAPK1 RND1 RND1 NCK2 NCK2 NEO1 NEO1 CFL2 CFL2 BMPR1B BMPR1B UNC5C UNC5C SEMA6C SEMA6C RASA1 RASA1 RAC2 RAC2 PPP3CB PPP3CB RAF1 RAF1 MYL12A MYL12A MET MET PAK6 PAK6 PAK1 PAK1 FZD3 FZD3 EPHA8 EPHA8 NTN3 NTN3 GNAI2 GNAI2 SEMA4D SEMA4D EPHB1 EPHB1 RHOD RHOD ARHGEF12 ARHGEF12 SMO SMO NCK1 NCK1 DPYSL5 DPYSL5 SEMA4C SEMA4C SLIT1 SLIT1 SEMA3B SEMA3B NFATC4 NFATC4 NFATC3 NFATC3 SRGAP2 SRGAP2 TRPC6 TRPC6 BMPR2 BMPR2 NFATC2 NFATC2 ROCK1 ROCK1 PIK3CB PIK3CB WNT5B WNT5B EFNA4 EFNA4 PPP3CA PPP3CA RYK RYK SEMA3D SEMA3D SEMA3A SEMA3A EPHA6 EPHA6 SLIT2 SLIT2 PLXNC1 PLXNC1 TRPC5 TRPC5 EPHA7 EPHA7 PARD3 PARD3 ITGB1 ITGB1 EFNB2 EFNB2 PIK3R1 PIK3R1 PRKCZ PRKCZ NRAS NRAS PPP3R1 PPP3R1 LRRC4 LRRC4 CAMK2A CAMK2A CFL1 CFL1 EPHB4 EPHB4 GNAI1 GNAI1 PLXNA4 PLXNA4 SRGAP1 SRGAP1 ILK ILK SSH3 SSH3 GNAI3 GNAI3 SEMA4F SEMA4F CXCL12 CXCL12 PIK3R3 PIK3R3 PPP3CC PPP3CC ROCK2 ROCK2 PLXNB3 PLXNB3 EFNA3 EFNA3 PLXNB1 PLXNB1 PTK2 PTK2 SRC SRC G3UIA1_LOXAF G3UIA1_LOXAF RGMA RGMA EPHA1 EPHA1 RRAS RRAS SHH SHH MAPK3 MAPK3 SSH1 SSH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA3EPH receptor A3. (984 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
MYL9Myosin light chain 9. (172 aa)
PIK3R2Uncharacterized protein. (724 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1104 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (978 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
SEMA5BSemaphorin 5B. (1151 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
PARD6GPar-6 family cell polarity regulator gamma. (360 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (493 aa)
LIMK2LIM domain kinase 2. (617 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (921 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DPYSL2Dihydropyrimidinase like 2. (572 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
SEMA5ASemaphorin 5A. (1073 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (300 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (187 aa)
NTN4Netrin 4. (628 aa)
PARD6BPar-6 family cell polarity regulator beta. (371 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (744 aa)
MYL12BMyosin light chain 12B. (172 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
NTN1Netrin 1. (558 aa)
PDK1Protein-serine/threonine kinase. (389 aa)
UNC5DUnc-5 netrin receptor D. (926 aa)
SSH2Slingshot protein phosphatase 2. (1449 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (808 aa)
PAK4P21 (RAC1) activated kinase 4. (579 aa)
UNC5BUnc-5 netrin receptor B. (937 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
CDC42Uncharacterized protein. (147 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1071 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (784 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
EPHB2EPH receptor B2. (978 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ABLIM3Actin binding LIM protein family member 3. (682 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ABL1Tyrosine-protein kinase. (1142 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
ROBO1Roundabout guidance receptor 1. (1590 aa)
EPHA2EPH receptor A2. (977 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PAK5Non-specific serine/threonine protein kinase. (721 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (776 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NTNG1Netrin G1. (460 aa)
RHOARas homolog family member A. (193 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (773 aa)
SLIT3Uncharacterized protein. (750 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
RND1Rho family GTPase 1. (232 aa)
NCK2Cytoplasmic protein. (379 aa)
NEO1Neogenin 1. (1443 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
UNC5CUnc-5 netrin receptor C. (950 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (967 aa)
RASA1RAS p21 protein activator 1. (1043 aa)
RAC2Rac family small GTPase 2. (194 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
MYL12AMyosin light chain 12A. (172 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
PAK6Non-specific serine/threonine protein kinase. (683 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
EPHA8EPH receptor A8. (974 aa)
NTN3Netrin 3. (580 aa)
GNAI2G protein subunit alpha i2. (354 aa)
SEMA4DSema domain-containing protein; Belongs to the semaphorin family. (302 aa)
EPHB1Uncharacterized protein. (716 aa)
RHODRas homolog family member D. (210 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1452 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
NCK1Cytoplasmic protein. (377 aa)
DPYSL5Dihydropyrimidinase like 5. (564 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SLIT1Slit guidance ligand 1. (1396 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (747 aa)
NFATC4Nuclear factor of activated T cells 4. (705 aa)
NFATC3Nuclear factor of activated T cells 3. (1067 aa)
SRGAP2Uncharacterized protein. (1013 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (929 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
NFATC2Nuclear factor of activated T cells 2. (926 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (206 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
RYKReceptor like tyrosine kinase. (535 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (776 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
EPHA6EPH receptor A6. (1036 aa)
SLIT2Slit guidance ligand 2. (1522 aa)
PLXNC1Plexin C1. (1577 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
EPHA7EPH receptor A7. (998 aa)
PARD3Par-3 family cell polarity regulator. (1331 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP3R1Uncharacterized protein. (169 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (226 aa)
EPHB4EPH receptor B4. (995 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PLXNA4Plexin A4. (1438 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1097 aa)
ILKIntegrin linked kinase. (452 aa)
SSH3Slingshot protein phosphatase 3. (660 aa)
GNAI3G protein subunit alpha i3. (353 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PIK3R3Uncharacterized protein. (509 aa)
PPP3CCSerine/threonine-protein phosphatase. (512 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PLXNB3Plexin B3. (1907 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (228 aa)
PLXNB1Plexin B1. (2125 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
SRCTyrosine-protein kinase. (542 aa)
G3UIA1_LOXAFEph LBD domain-containing protein. (351 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (437 aa)
EPHA1EPH receptor A1. (976 aa)
RRASRAS related. (219 aa)
SHHSonic hedgehog signaling molecule. (337 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
SSH1Slingshot protein phosphatase 1. (597 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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