STRINGSTRING
RAP1A RAP1A MYL9 MYL9 ERBB2 ERBB2 RAPGEF2 RAPGEF2 TIAM1 TIAM1 RAPGEF6 RAPGEF6 MAP3K5 MAP3K5 ACTN1 ACTN1 CLDN14 CLDN14 MAP3K1 MAP3K1 LLGL1 LLGL1 ACTB ACTB PARD6G PARD6G RAB8B RAB8B TJP1 TJP1 GATA4 GATA4 RAP2C RAP2C G3SSL0_LOXAF G3SSL0_LOXAF RAB8A RAB8A PARD6B PARD6B RUNX1 RUNX1 MYL12B MYL12B OCLN OCLN PRKCI PRKCI MAP2K7 MAP2K7 PRKAG1 PRKAG1 JAM2 JAM2 PRKAB1 PRKAB1 PRKCE PRKCE CFTR CFTR CDC42 CDC42 MYH10 MYH10 MYH9 MYH9 PCNA PCNA PRKACB PRKACB SYNPO SYNPO EPB41L4B EPB41L4B PARD6A PARD6A G3SZN8_LOXAF G3SZN8_LOXAF CLDN19 CLDN19 CCND1 CCND1 PATJ PATJ CLDN1 CLDN1 CLDN16 CLDN16 G3T189_LOXAF G3T189_LOXAF SYMPK SYMPK TUBA4A TUBA4A TUBA8 TUBA8 EZR EZR TJP2 TJP2 BVES BVES AMOTL2 AMOTL2 RHOA RHOA ACTR2 ACTR2 HSPA4 HSPA4 CDK4 CDK4 CLDN5 CLDN5 NEDD4L NEDD4L ARHGEF2 ARHGEF2 CD1E CD1E CLDN11 CLDN11 STK11 STK11 MYL12A MYL12A LLGL2 LLGL2 PRKAG2 PRKAG2 MAPK10 MAPK10 MARVELD2 MARVELD2 MYL6B MYL6B PRKAA2 PRKAA2 ACTR3 ACTR3 MPP5 MPP5 CD1D CD1D DLG1 DLG1 PPP2R2B PPP2R2B MYH11 MYH11 RDX RDX ROCK1 ROCK1 CLDN4 CLDN4 PPP2R2D PPP2R2D CGNL1 CGNL1 PRKAG3 PRKAG3 CLDN6 CLDN6 CTTN CTTN PPP2CA PPP2CA YBX3 YBX3 PPP2R1A PPP2R1A CLDN15 CLDN15 PRKAA1 PRKAA1 MAGI1 MAGI1 PARD3 PARD3 ITGB1 ITGB1 MPDZ MPDZ PRKCZ PRKCZ JUN JUN JAM3 JAM3 AMOTL1 AMOTL1 PPP2R2A PPP2R2A F11R F11R TJAP1 TJAP1 NF2 NF2 ACTR3B ACTR3B PPP2R1B PPP2R1B PRKACA PRKACA CLDN9 CLDN9 G3U0W1_LOXAF G3U0W1_LOXAF CD1C CD1C WAS WAS PRKAB2 PRKAB2 CLDN17 CLDN17 G3U6K2_LOXAF G3U6K2_LOXAF CLDN8 CLDN8 ROCK2 ROCK2 PPP2CB PPP2CB MAPK8 MAPK8 SRC SRC LOC100668473 LOC100668473 MAPK9 MAPK9 CLDN2 CLDN2 IGSF5 IGSF5 LOC100670825 LOC100670825 TUBA1B TUBA1B G3UJQ4_LOXAF G3UJQ4_LOXAF ACTG1 ACTG1 CLDN3 CLDN3 TJP3 TJP3 MYH14 MYH14 CLDN23 CLDN23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MYL9Myosin light chain 9. (172 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1512 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
RAPGEF6Uncharacterized protein. (1614 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
ACTN1Actinin alpha 1. (892 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1497 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1003 aa)
ACTBActin beta. (381 aa)
PARD6GPar-6 family cell polarity regulator gamma. (360 aa)
RAB8BRAB8B, member RAS oncogene family. (166 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1750 aa)
GATA4GATA binding protein 4. (383 aa)
RAP2CRAP2C, member of RAS oncogene family. (183 aa)
G3SSL0_LOXAFPH domain-containing protein. (748 aa)
RAB8ARAB8A, member RAS oncogene family. (183 aa)
PARD6BPar-6 family cell polarity regulator beta. (371 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (449 aa)
MYL12BMyosin light chain 12B. (172 aa)
OCLNOccludin_ELL domain-containing protein. (229 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (314 aa)
JAM2Junctional adhesion molecule 2. (261 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (607 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1479 aa)
CDC42Uncharacterized protein. (147 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1987 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1958 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SYNPOSynaptopodin. (890 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (821 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
G3SZN8_LOXAFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PATJPATJ crumbs cell polarity complex component. (1833 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
G3T189_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
SYMPKSymplekin. (1274 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
EZREzrin. (587 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1151 aa)
BVESBlood vessel epicardial substance. (360 aa)
AMOTL2Angiomotin like 2. (779 aa)
RHOARas homolog family member A. (193 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (840 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (226 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
NEDD4LE3 ubiquitin-protein ligase. (940 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (988 aa)
CD1ECD1e molecule. (389 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
STK11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
MYL12AMyosin light chain 12A. (172 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1028 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (326 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
MARVELD2MARVEL domain containing 2. (559 aa)
MYL6BMyosin light chain 6B. (208 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (403 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
CD1DCD1d molecule. (337 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
RDXRadixin. (600 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
CGNL1Cingulin like 1. (1305 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CTTNCortactin. (550 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
YBX3Y-box binding protein 3. (368 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (241 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1366 aa)
PARD3Par-3 family cell polarity regulator. (1331 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2064 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
JAM3Junctional adhesion molecule 3. (311 aa)
AMOTL1Angiomotin like 1. (939 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (491 aa)
F11RF11 receptor. (282 aa)
TJAP1Tight junction associated protein 1. (549 aa)
NF2Neurofibromin 2. (596 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (380 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (697 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
G3U0W1_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
CD1CCD1c molecule. (332 aa)
WASWASP actin nucleation promoting factor. (502 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
G3U6K2_LOXAFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PPP2CBSerine/threonine-protein phosphatase. (276 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
SRCTyrosine-protein kinase. (542 aa)
LOC100668473Uncharacterized protein. (203 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
IGSF5Uncharacterized protein. (368 aa)
LOC100670825Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
G3UJQ4_LOXAFUncharacterized protein. (400 aa)
ACTG1Actin gamma 1. (379 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (940 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1999 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (291 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (20%) [HD]