STRINGSTRING
PTGS1 PTGS1 RAP1A RAP1A PIK3R2 PIK3R2 ACTB ACTB RASGRP1 RASGRP1 PLA2G4A PLA2G4A ADCY5 ADCY5 PIK3CD PIK3CD VAMP8 VAMP8 GNAQ GNAQ GNA13 GNA13 PLCG2 PLCG2 MYLK2 MYLK2 VWF VWF TLN1 TLN1 PLCB1 PLCB1 GP5 GP5 AKT2 AKT2 ITPR1 ITPR1 PIK3CA PIK3CA GUCY1A2 GUCY1A2 ADCY9 ADCY9 PLA2G4D PLA2G4D PLA2G4F PLA2G4F ITGA2B ITGA2B MYL12B MYL12B PIK3CG PIK3CG PRKCI PRKCI ADCY2 ADCY2 PLA2G4E PLA2G4E MAPK14 MAPK14 MAPK13 MAPK13 P2RX1 P2RX1 PPP1CB PPP1CB SNAP23 SNAP23 ITPR2 ITPR2 TBXAS1 TBXAS1 PLCB4 PLCB4 PRKACB PRKACB NOS3 NOS3 PRKG2 PRKG2 LYN LYN ADCY1 ADCY1 PRKG1 PRKG1 FERMT3 FERMT3 PLCB3 PLCB3 ADCY8 ADCY8 RHOA RHOA ADCY7 ADCY7 MAPK1 MAPK1 F2 F2 MYL12A MYL12A PLCB2 PLCB2 SYK SYK ADCY4 ADCY4 LCP2 LCP2 GNAI2 GNAI2 PLA2G4B PLA2G4B ARHGEF12 ARHGEF12 ITGB3 ITGB3 ADCY6 ADCY6 ADCY3 ADCY3 RASGRP2 RASGRP2 MYLK4 MYLK4 PPP1R12A PPP1R12A GUCY1A1 GUCY1A1 GUCY1B1 GUCY1B1 ROCK1 ROCK1 PIK3CB PIK3CB RAP1B RAP1B COL3A1 COL3A1 LOC100676051 LOC100676051 MAPK12 MAPK12 AKT3 AKT3 PIK3R5 PIK3R5 COL1A2 COL1A2 BTK BTK FGB FGB FGG FGG ITGB1 ITGB1 ITGA2 ITGA2 PIK3R1 PIK3R1 ARHGAP35 ARHGAP35 PRKCZ PRKCZ LOC100669226 LOC100669226 P2RY12 P2RY12 PPP1CA PPP1CA GNAI1 GNAI1 ITPR3 ITPR3 PTGIR PTGIR TBXA2R TBXA2R PRKACA PRKACA GNAI3 GNAI3 PIK3R3 PIK3R3 TLN2 TLN2 ROCK2 ROCK2 SRC SRC COL1A1 COL1A1 G3UF61_LOXAF G3UF61_LOXAF P2RY1 P2RY1 APBB1IP APBB1IP ACTG1 ACTG1 GP1BA GP1BA GP9 GP9 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGS1Prostaglandin-endoperoxide synthase 1. (600 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PIK3R2Uncharacterized protein. (724 aa)
ACTBActin beta. (381 aa)
RASGRP1RAS guanyl releasing protein 1. (792 aa)
PLA2G4APhospholipase A2. (748 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
GNAQG protein subunit alpha q. (316 aa)
GNA13G protein subunit alpha 13. (284 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MYLK2Myosin light chain kinase 2. (605 aa)
VWFVon Willebrand factor. (2812 aa)
TLN1Talin 1. (2547 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
GP5Glycoprotein V platelet. (557 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (503 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
PLA2G4DPhospholipase A2. (798 aa)
PLA2G4FPhospholipase A2. (852 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1036 aa)
MYL12BMyosin light chain 12B. (172 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1112 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
PLA2G4EPhospholipase A2. (809 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
ITPR2Ion_trans domain-containing protein. (495 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (533 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1199 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
LYNTyrosine-protein kinase. (512 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (489 aa)
FERMT3Fermitin family member 3. (665 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1245 aa)
RHOARas homolog family member A. (193 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (619 aa)
MYL12AMyosin light chain 12A. (172 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
SYKTyrosine-protein kinase. (629 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LCP2Lymphocyte cytosolic protein 2. (535 aa)
GNAI2G protein subunit alpha i2. (354 aa)
PLA2G4BPhospholipase A2. (776 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1452 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
RASGRP2RAS guanyl releasing protein 2. (668 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (298 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAP1BUncharacterized protein. (184 aa)
COL3A1Collagen type III alpha 1 chain. (1470 aa)
LOC100676051Guanylate cyclase domain-containing protein. (672 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (878 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
BTKTyrosine-protein kinase. (661 aa)
FGBFibrinogen beta chain. (483 aa)
FGGFibrinogen gamma chain. (444 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
LOC100669226Uncharacterized protein. (247 aa)
P2RY12Purinergic receptor P2Y12. (347 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
PTGIRProstaglandin I2 receptor. (423 aa)
TBXA2RThromboxane A2 receptor. (297 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
GNAI3G protein subunit alpha i3. (353 aa)
PIK3R3Uncharacterized protein. (509 aa)
TLN2Talin 2. (2547 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
SRCTyrosine-protein kinase. (542 aa)
COL1A1Collagen type I alpha 1 chain. (1455 aa)
G3UF61_LOXAFUncharacterized protein. (393 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
APBB1IPUncharacterized protein. (305 aa)
ACTG1Actin gamma 1. (379 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (546 aa)
GP9Glycoprotein IX platelet. (189 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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