STRINGSTRING
CXCL8 CXCL8 PIK3R2 PIK3R2 PIK3CD PIK3CD IRAK4 IRAK4 AKT2 AKT2 PIK3CA PIK3CA IL1B IL1B IKBKB IKBKB MAP2K6 MAP2K6 MAP2K7 MAP2K7 MAPK14 MAPK14 MAPK13 MAPK13 LBP LBP SPP1 SPP1 TBK1 TBK1 TLR4 TLR4 TNF TNF CXCL10 CXCL10 TLR1 TLR1 NFKB1 NFKB1 MAPK1 MAPK1 RIPK1 RIPK1 TIRAP TIRAP LY96 LY96 TLR8 TLR8 MAPK10 MAPK10 MAP2K4 MAP2K4 MAP3K8 MAP3K8 IFNAR2 IFNAR2 IFNAR1 IFNAR1 LOC100673788 LOC100673788 CHUK CHUK IL6 IL6 MAP2K2 MAP2K2 PIK3CB PIK3CB IL12B IL12B G3TGZ0_LOXAF G3TGZ0_LOXAF MAPK12 MAPK12 TOLLIP TOLLIP AKT3 AKT3 TLR3 TLR3 PIK3R1 PIK3R1 CASP8 CASP8 NFKBIA NFKBIA MAP3K7 MAP3K7 JUN JUN IRF5 IRF5 IKBKE IKBKE G3TS29_LOXAF G3TS29_LOXAF IKBKG IKBKG LOC100655463 LOC100655463 TRAF6 TRAF6 CD86 CD86 STAT1 STAT1 CCL5 CCL5 G3U0Z2_LOXAF G3U0Z2_LOXAF CTSK CTSK PIK3R3 PIK3R3 MYD88 MYD88 MAP2K3 MAP2K3 IRF3 IRF3 TAB2 TAB2 TAB1 TAB1 MAPK8 MAPK8 CXCL9 CXCL9 G3UCD2_LOXAF G3UCD2_LOXAF MAPK9 MAPK9 RELA RELA TLR9 TLR9 G3UH32_LOXAF G3UH32_LOXAF TICAM1 TICAM1 IFNB1 IFNB1 G3UKJ3_LOXAF G3UKJ3_LOXAF TLR2 TLR2 TLR6 TLR6 CXCL11 CXCL11 TLR7 TLR7 G3UMR8_LOXAF G3UMR8_LOXAF MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXCL8Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
PIK3R2Uncharacterized protein. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (459 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LBPLipopolysaccharide binding protein. (481 aa)
SPP1Secreted phosphoprotein 1. (310 aa)
TBK1TANK binding kinase 1. (730 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
CXCL10C-X-C motif chemokine. (98 aa)
TLR1Toll like receptor 1. (771 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
LY96ML domain-containing protein. (87 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1030 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (326 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
IFNAR2Uncharacterized protein. (481 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (555 aa)
LOC100673788C-C motif chemokine. (92 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
IL6Interleukin 6. (212 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
G3TGZ0_LOXAFUncharacterized protein. (202 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
TOLLIPToll interacting protein. (274 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (478 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
IRF5Interferon regulatory factor 5. (501 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (722 aa)
G3TS29_LOXAFUncharacterized protein. (183 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
LOC100655463C-C motif chemokine. (93 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CD86Ig-like domain-containing protein. (291 aa)
STAT1Signal transducer and activator of transcription. (756 aa)
CCL5SCY domain-containing protein. (95 aa)
G3U0Z2_LOXAFUncharacterized protein. (194 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
PIK3R3Uncharacterized protein. (509 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (293 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (425 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (506 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
CXCL9C-X-C motif chemokine. (126 aa)
G3UCD2_LOXAFUncharacterized protein. (195 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
TLR9TIR domain-containing protein. (1030 aa)
G3UH32_LOXAFUncharacterized protein. (361 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (700 aa)
IFNB1Interferon beta 1. (187 aa)
G3UKJ3_LOXAFUncharacterized protein. (191 aa)
TLR2Toll-like receptor. (783 aa)
TLR6Toll-like receptor. (776 aa)
CXCL11C-X-C motif chemokine. (100 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1040 aa)
G3UMR8_LOXAFUncharacterized protein. (125 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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