STRINGSTRING
RAP1A RAP1A RHOH RHOH MYL9 MYL9 RASSF5 RASSF5 ITGA4 ITGA4 ACTN1 ACTN1 PIK3R2 PIK3R2 CLDN14 CLDN14 PRKCB PRKCB ACTB ACTB PIK3CD PIK3CD PLCG2 PLCG2 PTPN11 PTPN11 PIK3CA PIK3CA MMP2 MMP2 MYL12B MYL12B PLCG1 PLCG1 OCLN OCLN MAPK14 MAPK14 MAPK13 MAPK13 PTK2B PTK2B JAM2 JAM2 PRKCA PRKCA CDC42 CDC42 CXCR4 CXCR4 CDH5 CDH5 G3SZN8_LOXAF G3SZN8_LOXAF CLDN19 CLDN19 CLDN1 CLDN1 CLDN16 CLDN16 NCF2 NCF2 ESAM ESAM EZR EZR RHOA RHOA RAPGEF4 RAPGEF4 VAV2 VAV2 CLDN5 CLDN5 RAC2 RAC2 CLDN11 CLDN11 MYL12A MYL12A CTNND1 CTNND1 ARHGAP5 ARHGAP5 PECAM1 PECAM1 CYBB CYBB GNAI2 GNAI2 ITGAL ITGAL ITGAM ITGAM TXK TXK RAPGEF3 RAPGEF3 ROCK1 ROCK1 CLDN4 CLDN4 PIK3CB PIK3CB RAP1B RAP1B CLDN6 CLDN6 MAPK12 MAPK12 THY1 THY1 VAV3 VAV3 CLDN15 CLDN15 CTNNA3 CTNNA3 ITGB1 ITGB1 PIK3R1 PIK3R1 CTNNB1 CTNNB1 ARHGAP35 ARHGAP35 VAV1 VAV1 MMP9 MMP9 CD99L2 CD99L2 JAM3 JAM3 F11R F11R GNAI1 GNAI1 BCAR1 BCAR1 CLDN9 CLDN9 GNAI3 GNAI3 PRKCG PRKCG CXCL12 CXCL12 PIK3R3 PIK3R3 SIPA1 SIPA1 CLDN17 CLDN17 CLDN8 CLDN8 ROCK2 ROCK2 PXN PXN ITGB2 ITGB2 PTK2 PTK2 CLDN2 CLDN2 LOC100670825 LOC100670825 CTNNA2-2 CTNNA2-2 ACTG1 ACTG1 CLDN3 CLDN3 CTNNA1 CTNNA1 CLDN23 CLDN23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RHOHRas homolog family member H. (191 aa)
MYL9Myosin light chain 9. (172 aa)
RASSF5Ras association domain family member 5. (414 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
ACTN1Actinin alpha 1. (892 aa)
PIK3R2Uncharacterized protein. (724 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ACTBActin beta. (381 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MMP2Matrix metallopeptidase 2. (665 aa)
MYL12BMyosin light chain 12B. (172 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
OCLNOccludin_ELL domain-containing protein. (229 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
JAM2Junctional adhesion molecule 2. (261 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
CDC42Uncharacterized protein. (147 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (759 aa)
G3SZN8_LOXAFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
NCF2Neutrophil cytosolic factor 2. (520 aa)
ESAMEndothelial cell adhesion molecule. (393 aa)
EZREzrin. (587 aa)
RHOARas homolog family member A. (193 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
VAV2Vav guanine nucleotide exchange factor 2. (866 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
RAC2Rac family small GTPase 2. (194 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
MYL12AMyosin light chain 12A. (172 aa)
CTNND1Catenin delta 1. (964 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (709 aa)
CYBBCytochrome b-245 beta chain. (571 aa)
GNAI2G protein subunit alpha i2. (354 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1162 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
TXKTyrosine-protein kinase. (528 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (907 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAP1BUncharacterized protein. (184 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
THY1Thy-1 cell surface antigen. (161 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (241 aa)
CTNNA3Catenin alpha 3. (547 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CTNNB1Catenin beta 1. (780 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
MMP9Matrix metallopeptidase 9. (729 aa)
CD99L2Uncharacterized protein. (173 aa)
JAM3Junctional adhesion molecule 3. (311 aa)
F11RF11 receptor. (282 aa)
GNAI1G protein subunit alpha i1. (354 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (869 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
GNAI3G protein subunit alpha i3. (353 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PIK3R3Uncharacterized protein. (509 aa)
SIPA1Signal-induced proliferation-associated 1. (1037 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (587 aa)
ITGB2Integrin beta. (740 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
LOC100670825Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CTNNA2-2Uncharacterized protein. (257 aa)
ACTG1Actin gamma 1. (379 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CTNNA1Catenin alpha 1. (905 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (291 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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