STRINGSTRING
RAP1A RAP1A BCL2 BCL2 MAP3K5 MAP3K5 PIK3R2 PIK3R2 MAP3K1 MAP3K1 CALM3 CALM3 NTRK1 NTRK1 MAP2K5 MAP2K5 PRDM4 PRDM4 PIK3CD PIK3CD IRAK4 IRAK4 PLCG2 PLCG2 PTPN11 PTPN11 NTF3 NTF3 GAB1 GAB1 IRAK2 IRAK2 AKT2 AKT2 PIK3CA PIK3CA NGFR NGFR PLCG1 PLCG1 CALML5 CALML5 IKBKB IKBKB RPS6KA1 RPS6KA1 MAP2K7 MAP2K7 MAPK14 MAPK14 MAPK13 MAPK13 CDC42 CDC42 FOXO3 FOXO3 GRB2 GRB2 YWHAE YWHAE CAMK4 CAMK4 ABL1 ABL1 TP73 TP73 RPS6KA3 RPS6KA3 NTRK2 NTRK2 IRAK3 IRAK3 CALML3 CALML3 SH2B3 SH2B3 TP53 TP53 RPS6KA6 RPS6KA6 GSK3B GSK3B SHC4 SHC4 SOS2 SOS2 NFKB1 NFKB1 RHOA RHOA SHC1 SHC1 MAPK1 MAPK1 MAP3K3 MAP3K3 MAPK7 MAPK7 SOS1 SOS1 RAF1 RAF1 ATF4 ATF4 MAPK10 MAPK10 FASLG FASLG SHC3 SHC3 KIDINS220 KIDINS220 CRKL CRKL FRS2 FRS2 NTRK3 NTRK3 MAP2K2 MAP2K2 PIK3CB PIK3CB RAP1B RAP1B MAPK12 MAPK12 SH2B1 SH2B1 AKT3 AKT3 SORT1 SORT1 PIK3R1 PIK3R1 NFKBIB NFKBIB NFKBIA NFKBIA MAPKAPK2 MAPKAPK2 NRAS NRAS JUN JUN ARHGDIA ARHGDIA CAMK2A CAMK2A BAD BAD CALML4 CALML4 MATK MATK PRKCD PRKCD TRAF6 TRAF6 NGF NGF CRK CRK PDPK1 PDPK1 ARHGDIB ARHGDIB BEX3 BEX3 RIPK2 RIPK2 PIK3R3 PIK3R3 PSEN1 PSEN1 MAPK8 MAPK8 IRS1 IRS1 ARHGDIG ARHGDIG MAPK9 MAPK9 MAGED1 MAGED1 RELA RELA RPS6KA2 RPS6KA2 BDNF BDNF MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1371 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1497 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (150 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (446 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (788 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (459 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
GAB1GRB2 associated binding protein 1. (694 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (626 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NGFRNerve growth factor receptor. (414 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1220 aa)
CALML5Calmodulin like 5. (149 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (703 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (497 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CDC42Uncharacterized protein. (147 aa)
FOXO3Forkhead box O3. (672 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (419 aa)
ABL1Tyrosine-protein kinase. (1142 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (608 aa)
RPS6KA3Ribosomal protein S6 kinase. (737 aa)
NTRK2Tyrosine-protein kinase receptor. (820 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (588 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SH2B3SH2B adaptor protein 3. (568 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (703 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
RHOARas homolog family member A. (193 aa)
SHC1SHC adaptor protein 1. (583 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (629 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (801 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ATF4Activating transcription factor 4. (379 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (277 aa)
SHC3SHC adaptor protein 3. (463 aa)
KIDINS220Kinase D interacting substrate 220. (1764 aa)
CRKLCRK like proto-oncogene, adaptor protein. (200 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
NTRK3Tyrosine-protein kinase receptor. (825 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAP1BUncharacterized protein. (184 aa)
MAPK12Mitogen-activated protein kinase. (262 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SORT1Sortilin. (729 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NFKBIBNFKB inhibitor beta. (355 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MAPKAPK2MAPK activated protein kinase 2. (308 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (206 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
BADBCL2 associated agonist of cell death. (206 aa)
CALML4Calmodulin like 4. (153 aa)
MATKTyrosine-protein kinase. (507 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (242 aa)
CRKCRK proto-oncogene, adaptor protein. (307 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (202 aa)
BEX3Brain expressed X-linked 3. (113 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
PIK3R3Uncharacterized protein. (509 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (440 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
IRS1Insulin receptor substrate 1. (1119 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (187 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
MAGED1MAGE family member D1. (757 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
RPS6KA2Ribosomal protein S6 kinase. (737 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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