STRINGSTRING
BCL2 BCL2 PIK3R2 PIK3R2 PRKCB PRKCB ADCY5 ADCY5 GNB5 GNB5 PIK3CD PIK3CD GNAQ GNAQ GNG13 GNG13 GNAO1 GNAO1 PLCB1 PLCB1 AKT2 AKT2 ITPR1 ITPR1 PIK3CA PIK3CA GNG2 GNG2 GNG12 GNG12 ADCY9 ADCY9 PIK3CG PIK3CG ADCY2 ADCY2 CREB3L1 CREB3L1 GNG3 GNG3 CHRNA4 CHRNA4 ITPR2 ITPR2 KCNQ3 KCNQ3 PRKCA PRKCA PLCB4 PLCB4 PRKACB PRKACB GNB3 GNB3 CAMK4 CAMK4 GNG5 GNG5 KCNJ2 KCNJ2 KCNJ6 KCNJ6 JAK2 JAK2 KCNJ14 KCNJ14 ACHE ACHE SLC5A7 SLC5A7 CREB3L2 CREB3L2 ADCY1 ADCY1 G3T2T7_LOXAF G3T2T7_LOXAF PLCB3 PLCB3 ADCY8 ADCY8 KCNJ12 KCNJ12 ADCY7 ADCY7 MAPK1 MAPK1 GNA11 GNA11 PLCB2 PLCB2 ATF4 ATF4 ADCY4 ADCY4 GNAI2 GNAI2 CHRNA3 CHRNA3 CHRNB4 CHRNB4 CREB1 CREB1 ADCY6 ADCY6 CACNA1S CACNA1S ADCY3 ADCY3 CREB3 CREB3 SLC18A3 SLC18A3 CHAT CHAT PIK3CB PIK3CB GNB1 GNB1 AKT3 AKT3 GNB2 GNB2 PIK3R5 PIK3R5 CHRNB2 CHRNB2 CREB3L4 CREB3L4 PIK3R1 PIK3R1 GNG11 GNG11 NRAS NRAS GNG7 GNG7 KCNJ3 KCNJ3 CAMK2A CAMK2A GNAI1 GNAI1 ITPR3 ITPR3 PRKACA PRKACA CHRM5 CHRM5 KCNQ4 KCNQ4 GNGT1 GNGT1 GNAI3 GNAI3 PRKCG PRKCG CHRNA6 CHRNA6 GNGT2 GNGT2 PIK3R3 PIK3R3 CHRM3 CHRM3 KCNQ1 KCNQ1 CHRM2 CHRM2 CREB5 CREB5 KCNJ4 KCNJ4 CHRM4 CHRM4 GNG4 GNG4 GNG10 GNG10 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2BCL2 apoptosis regulator. (229 aa)
PIK3R2Uncharacterized protein. (724 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
GNB5G protein subunit beta 5. (393 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
GNAQG protein subunit alpha q. (316 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1112 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (614 aa)
ITPR2Ion_trans domain-containing protein. (495 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (743 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB3G protein subunit beta 3. (340 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (419 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (413 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (614 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
G3T2T7_LOXAFUncharacterized protein. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1245 aa)
KCNJ12Uncharacterized protein. (443 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
GNA11G protein subunit alpha 11. (314 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
ATF4Activating transcription factor 4. (379 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNAI2G protein subunit alpha i2. (354 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (493 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (475 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1685 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
SLC18A3Solute carrier family 18 member A3. (527 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNB2G protein subunit beta 2. (371 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (878 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (500 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (375 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (526 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAI3G protein subunit alpha i3. (353 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PIK3R3Uncharacterized protein. (509 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (332 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (430 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.