STRINGSTRING
CXCL8 CXCL8 ACTN1 ACTN1 PIK3R2 PIK3R2 LAMB1 LAMB1 PRKCB PRKCB ARG2 ARG2 PIK3CD PIK3CD GNAQ GNAQ TGFB2 TGFB2 PLCB1 PLCB1 PIK3CA PIK3CA LAMA2 LAMA2 C8A C8A C8B C8B ARG1 ARG1 IL1B IL1B LAMA4 LAMA4 COL4A4 COL4A4 IFNG IFNG LAMB3 LAMB3 CTSG CTSG PRKCA PRKCA PLCB4 PLCB4 PRKACB PRKACB TLR4 TLR4 SERPINB9 SERPINB9 TGFB1 TGFB1 TNF TNF GNAL GNAL RAB7A RAB7A LAMA3 LAMA3 RAB5A RAB5A SERPINB10 SERPINB10 GNA14 GNA14 ADCY1 ADCY1 COL4A2 COL4A2 PLCB3 PLCB3 NFKB1 NFKB1 GNA11 GNA11 CD1E CD1E COL4A3 COL4A3 LAMC3 LAMC3 PLCB2 PLCB2 SERPINB6 SERPINB6 IL1R1 IL1R1 LAMB2 LAMB2 IL1R2 IL1R2 CD1D CD1D ITGAM ITGAM IL6 IL6 PIK3CB PIK3CB IL12B IL12B COL3A1 COL3A1 COL1A2 COL1A2 CSF2 CSF2 PRDX1 PRDX1 COL4A5 COL4A5 RAB5B RAB5B PIK3R1 PIK3R1 LOC100669226 LOC100669226 IL10 IL10 C9 C9 TGFB3 TGFB3 COL4A1 COL4A1 CASP3 CASP3 COL4A6 COL4A6 PRKACA PRKACA C8G C8G PRKCG PRKCG CD1C CD1C PIK3R3 PIK3R3 G3U4T1_LOXAF G3U4T1_LOXAF LOC104847286 LOC104847286 LAMA5 LAMA5 ITGB2 ITGB2 LAMC1 LAMC1 PTK2 PTK2 G3UB11_LOXAF G3UB11_LOXAF COL1A1 COL1A1 NOS2 NOS2 G3UF61_LOXAF G3UF61_LOXAF LAMA1 LAMA1 RELA RELA G3UH32_LOXAF G3UH32_LOXAF LAMC2 LAMC2 TLR2 TLR2 G3UMR8_LOXAF G3UMR8_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXCL8Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
ACTN1Actinin alpha 1. (892 aa)
PIK3R2Uncharacterized protein. (724 aa)
LAMB1Laminin subunit beta 1. (1835 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ARG2Arginase. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
GNAQG protein subunit alpha q. (316 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMA2Laminin subunit alpha 2. (3121 aa)
C8AComplement C8 alpha chain. (541 aa)
C8BComplement C8 beta chain. (560 aa)
ARG1Arginase. (327 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
COL4A4Collagen type IV alpha 4 chain. (1446 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LAMB3Laminin subunit beta 3. (1170 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (245 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (377 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
GNALG protein subunit alpha L. (378 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
LAMA3Laminin subunit alpha 3. (3198 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (397 aa)
GNA14G protein subunit alpha 14. (355 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
COL4A2Collagen type IV alpha 2 chain. (1661 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
GNA11G protein subunit alpha 11. (314 aa)
CD1ECD1e molecule. (389 aa)
COL4A3Collagen type IV alpha 3 chain. (1672 aa)
LAMC3Laminin subunit gamma 3. (1465 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
SERPINB6Serpin family B member 6; Belongs to the serpin family. (378 aa)
IL1R1Interleukin 1 receptor type 1. (574 aa)
LAMB2Laminin subunit beta 2. (1799 aa)
IL1R2Interleukin 1 receptor type 2. (408 aa)
CD1DCD1d molecule. (337 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
IL6Interleukin 6. (212 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
COL3A1Collagen type III alpha 1 chain. (1470 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
CSF2Colony stimulating factor 2. (151 aa)
PRDX1Peroxiredoxin 1. (203 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
RAB5BRAB5B, member RAS oncogene family. (229 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC100669226Uncharacterized protein. (247 aa)
IL10Interleukin 10. (178 aa)
C9Complement C9. (512 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
COL4A1Collagen type IV alpha 1 chain. (1626 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (281 aa)
COL4A6Collagen type IV alpha 6 chain. (1651 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (201 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
CD1CCD1c molecule. (332 aa)
PIK3R3Uncharacterized protein. (509 aa)
G3U4T1_LOXAFUncharacterized protein. (205 aa)
LOC104847286Uncharacterized protein. (1164 aa)
LAMA5Laminin IV type A domain-containing protein. (145 aa)
ITGB2Integrin beta. (740 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
G3UB11_LOXAFIg-like domain-containing protein. (120 aa)
COL1A1Collagen type I alpha 1 chain. (1455 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
G3UF61_LOXAFUncharacterized protein. (393 aa)
LAMA1Laminin subunit alpha 1. (3060 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
G3UH32_LOXAFUncharacterized protein. (361 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
TLR2Toll-like receptor. (783 aa)
G3UMR8_LOXAFUncharacterized protein. (125 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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