STRINGSTRING
E2F3 E2F3 ERBB2 ERBB2 BCL2 BCL2 PIK3R2 PIK3R2 PIK3CD PIK3CD CCNE2 CCNE2 AKT2 AKT2 PIK3CA PIK3CA PDGFD PDGFD IKBKB IKBKB CREB3L1 CREB3L1 PTEN PTEN ERG ERG MDM2 MDM2 GRB2 GRB2 TP53 TP53 CCND1 CCND1 PDGFB PDGFB GSK3B GSK3B CREB3L2 CREB3L2 SOS2 SOS2 NKX3-1 NKX3-1 NFKB1 NFKB1 MAPK1 MAPK1 MMP3 MMP3 PLAT PLAT FOXO1 FOXO1 SOS1 SOS1 PDGFRA PDGFRA RAF1 RAF1 CCNE1 CCNE1 ATF4 ATF4 EP300 EP300 PDGFC PDGFC CREB1 CREB1 IL1R2 IL1R2 EGF EGF EGFR EGFR SPINT1 SPINT1 CHUK CHUK CREB3 CREB3 CREBBP CREBBP MAP2K2 MAP2K2 MTOR MTOR PIK3CB PIK3CB CASP9 CASP9 HSP90B1 HSP90B1 LEF1 LEF1 PLAU PLAU ETV5 ETV5 PDGFRB PDGFRB TCF7 TCF7 AKT3 AKT3 CREB3L4 CREB3L4 ARAF ARAF E2F1 E2F1 FGFR1 FGFR1 PIK3R1 PIK3R1 CTNNB1 CTNNB1 MMP9 MMP9 NFKBIA NFKBIA INS INS NRAS NRAS BAD BAD GSTP1 GSTP1 TGFA TGFA IKBKG IKBKG HSP90AB1 HSP90AB1 AR AR ZEB1 ZEB1 E2F2 E2F2 PDPK1 PDPK1 INSRR INSRR PIK3R3 PIK3R3 CDKN1A CDKN1A HSP90AA1 HSP90AA1 IGF1R IGF1R TMPRSS2 TMPRSS2 CREB5 CREB5 RELA RELA CDKN1B CDKN1B RB1 RB1 FGFR2 FGFR2 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F3E2F transcription factor 3. (460 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
PIK3R2Uncharacterized protein. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ERGETS transcription factor ERG. (486 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
NKX3-1NK3 homeobox 1. (248 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
MMP3Matrix metallopeptidase 3. (480 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
FOXO1FOXO-TAD domain-containing protein. (374 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ATF4Activating transcription factor 4. (379 aa)
EP300E1A binding protein p300. (2420 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
IL1R2Interleukin 1 receptor type 2. (408 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1168 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (491 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
CREBBPCREB binding protein. (2433 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (450 aa)
HSP90B1Heat shock protein 90 beta family member 1. (790 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
PLAUPlasminogen activator, urokinase. (406 aa)
ETV5ETS variant 5. (527 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
TCF7Transcription factor 7. (476 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (375 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (607 aa)
E2F1E2F transcription factor 1. (429 aa)
FGFR1Fibroblast growth factor receptor. (831 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CTNNB1Catenin beta 1. (780 aa)
MMP9Matrix metallopeptidase 9. (729 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (206 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
TGFATransforming growth factor alpha. (129 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
ARAndrogen receptor. (897 aa)
ZEB1Zinc finger E-box binding homeobox 1. (974 aa)
E2F2E2F transcription factor 2. (442 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
INSRRInsulin receptor related receptor. (1300 aa)
PIK3R3Uncharacterized protein. (509 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
HSP90AA1HATPase_c domain-containing protein. (736 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (490 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
RB1RB transcriptional corepressor 1. (925 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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